Meta-analyses of IL1A polymorphisms and the risk of several autoimmune diseases published in databases

Abstract

BackgroundBased on published data, we aimed to quantitatively elucidate the possible genetic influence of rs17561 and rs1800587 polymorphisms of the IL1A (interleukin 1 alpha) gene in the susceptibility to several autoimmune diseases.MethodsA series of meta-analyses were carried out. After database searching, we utilized our inclusion/exclusion criteria to screen and include the eligible studies. Passociation (P value of association test), Bonferroni-corrected Passociation value; false discovery rate (FDR)-corrected Passociation, ORs (odd ratios), and 95% CI (confidence interval) were generated to assess the magnitudes of genetic relationships.ResultsA total of 35 eligible articles were included. Pooled analysis data of both rs17561 and rs1800587 in the overall population indicated a negative association between cases of autoimmune diseases and negative controls (all Passociation>0.05, Bonferroni-corrected Passociation>0.05, FDR-corrected Passociation>0.05). Similar results were found in most subgroup analyses (all Passociation>0.05, Bonferroni-corrected Passociation>0.05, FDR-corrected Passociation>0.05), apart from the rs1800587 in the Graves’ disease subgroup, which showed an increased risk in some cases, compared with controls, under the models of allele vs. , carrier vs. , + vs. , and vs. (all Passociation<0.05, Bonferroni-corrected Passociation<0.05, FDR-corrected Passociation>0.05, OR>1).ConclusionBased on the available data, genotype of the rs1800587 polymorphism within IL1A gene may be associated with an increased Graves’ disease risk. We did not see evidence regarding a positive role for rs1800587 or rs17561 in the risk of other autoimmune diseases, such as systemic sclerosis or rheumatoid arthritis. These conclusions still merit further data support and molecular exploration.

IL‐1 signaling pathway molecules as key markers in childhood asthma

“…11 The members of the IL-1 family are not only the initiators but also the amplifiers of immune and inflammatory responses. 12 Inhibiting the IL-1 signaling network has been used for the treatment of inflammatory cytokinecaused autoimmune diseases and has shown promising treatment efficacy. 13 The PELI1 mRNA level has been reported to be increased in sputum from patients with recurrent asthma and COPD.…”

The association ofFOXP3gene polymorphisms with cancer susceptibility: a comprehensive systemic review and meta-analysis

“…The random-effects model was applied when I 2 > 50%, indicating the presence of heterogeneity. Otherwise, if the I 2 was less than 50%, the fixed-effects model was used [ 24 ]. The Z-test was then performed to determine the significance of the pooled ORs where P <0.05 was illustrated as statistically significant.…”

The Roles of IL-1 Family Cytokines in the Pathogenesis of Systemic Sclerosis

“…However, this association was not supported by other relevant studies (16). And in the meta-analysis, IL-1A rs17561 or rs1800587 polymorphism seems not to be statistically linked to the risk of SSc (17). Recently, a study demonstrated a significant association between the IL-1β (IL-1B) (+3962; rs1143634) SNP and the development of a severe ventilatory restriction in SSc patients.…”