Meta-analyses of clinical neuropsychological tests of executive dysfunction and impulsivity in alcohol use disorder

Stephan, Rick A.; Alhassoon, Omar M.; Allen, Kenneth E.; Wollman, Scott C; Hall, Matt; Thomas, William J.; Gamboa, Julia M; Kimmel, Chrissy; Stern, Mark J.; Sari, Celina; Dalenberg, Constance J.; Sorg, Scott F.; Grant, Igor

doi:10.1080/00952990.2016.1206113

Cited by 105 publications

(95 citation statements)

References 93 publications

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“…One polymorphism COMT Val158Met, that has been associated with AUD, alters frontal cortical efficiency, and presumably under via frontal dopamine mechanism, i.e., increased dopamine in the PFC is associated with improved executive functions, as proposed by Goldman-Rakic (104). Deficits in planning (105), set-shifting (106), and response inhibition (107) are more common in individuals with AUD than without. Relatedly, impulsivity was correlated with reduced reward anticipation in the ventral striatum among alcoholics but not in non-alcoholic comparison individuals (108), suggesting that high impulsivity is related to difficulty maintaining positive expectations about rewards.…”

Section: Stages Of the Addiction Cycle And The Addictions Neuroclimentioning

confidence: 99%

“…Relatedly, impulsivity was correlated with reduced reward anticipation in the ventral striatum among alcoholics but not in non-alcoholic comparison individuals (108), suggesting that high impulsivity is related to difficulty maintaining positive expectations about rewards. Finally, a recent meta-analysis of executive function impairments in AUD found some of the most significant executive impairments were in the domains of planning, response inhibition, and problem-solving (106). There is some recovery of function demonstrated during protracted abstinence (109), although ability to recover may be compromised among older patients (110).…”

Section: Stages Of the Addiction Cycle And The Addictions Neuroclimentioning

confidence: 99%

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Addictions Neuroclinical Assessment: A reverse translational approach

et al. 2017

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Incentive salience, negative emotionality, and executive function are functional domains that are etiologic in the initiation and progression of addictive disorders, having been implicated in humans with addictive disorders and in animal models of addictions. Measures of these three neuroscience-based functional domains can capture much of the effects of inheritance and early exposures that lead to trait vulnerability shared across different addictive disorders. For specific addictive disorders, these measures can be supplemented by agent specific measures such as those that access pharmacodynamic and pharmacokinetic variation attributable to agent-specific gatekeeper molecules including receptors and drug-metabolizing enzymes. Herein, we focus on the translation and reverse translation of knowledge derived from animal models of addiction to the human condition via measures of neurobiological processes that are orthologous in animals and humans, and that are shared in addictions to different agents. Based on preclinical data and human studies, measures of these domains in a general framework of an Addictions Neuroclinical Assessment (ANA) can transform the assessment and nosology of addictive disorders, and can be informative for staging disease progression. We consider next steps and challenges for implementation of ANA in clinical care and research.

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Section: Stages Of the Addiction Cycle And The Addictions Neuroclimentioning

confidence: 99%

Section: Stages Of the Addiction Cycle And The Addictions Neuroclimentioning

confidence: 99%

Addictions Neuroclinical Assessment: A reverse translational approach

et al. 2017

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“…One important risk mechanism, heightened behavioral impulsivity, has received particularly intensive study (Coskunpinar et al, 2013, Klein et al, 2016, Sanchez-Roige et al, 2016, Stephan et al, 2016, Wardell et al, 2016). Impulsivity can be characterized by questionnaire assessment or laboratory test.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study

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Zhornitsky

et al. 2017

NeuroImage: Clinical

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Alcohol expectancy and impulsivity are implicated in alcohol misuse. However, how these two risk factors interact to determine problem drinking and whether men and women differ in these risk processes remain unclear. In 158 social drinkers (86 women) assessed for Alcohol Use Disorder Identification Test (AUDIT), positive alcohol expectancy, and Barratt impulsivity, we examined sex differences in these risk processes. Further, with structural brain imaging, we examined the neural bases underlying the relationship between these risk factors and problem drinking. The results of general linear modeling showed that alcohol expectancy best predicted problem drinking in women, whereas in men as well as in the combined group alcohol expectancy and impulsivity interacted to best predict problem drinking. Alcohol expectancy was associated with decreased gray matter volume (GMV) of the right posterior insula in women and the interaction of alcohol expectancy and impulsivity was associated with decreased GMV of the left thalamus in women and men combined and in men alone, albeit less significantly. These risk factors mediated the correlation between GMV and problem drinking. Conversely, models where GMV resulted from problem drinking were not supported. These new findings reveal distinct psychological factors that dispose men and women to problem drinking. Although mediation analyses did not determine a causal link, GMV reduction in the insula and thalamus may represent neural phenotype of these risk processes rather than the consequence of alcohol consumption in non-dependent social drinkers. The results add to the alcohol imaging literature which has largely focused on dependent individuals and help elucidate alterations in brain structures that may contribute to the transition from social to habitual drinking.

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“…Heightened impulsivity and risk-taking behaviour have repeatedly been implicated in problematic alcohol consumption (Courtney et al, 2012;Fernie et al, 2010;Lane et al, 2004;Stephan et al, 2017). However, their association with alcohol use is complex, as heightened impulsivity and risk-taking are suggested to be predictors of excessive alcohol use, as well as the consequence of acute intoxication (de Wit, 2008).…”

Section: Introductionmentioning

confidence: 99%