Mésusage traditionnel du camphre: un danger oublié pour les enfants (à propos de 2 cas)

Nchinech, N; Elgharbi, Afaf; Aglili, Fatima Zahra; Kriouile, Yamna; Cherrah, Yahia; Mdaghri, Asmaa Aaloui; Serragui, Samira

doi:10.11604/pamj.2019.32.89.17943

Cited by 2 publications

(1 citation statement)

References 7 publications

(8 reference statements)

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“…EOs may be dangerous to human health if they are accidentally ingested or inadequately used. For example, even if the accidental ingestion of the anti-mosquito citronella oil by young children did not show very high toxicity, the use of traditional topical remedies containing camphor, menthol and eucalyptol caused convulsions in children aged between 2 months and 6 years [42]. Furthermore, cutaneous toxicity of EOs is more frequently reported and has been known for a very long period of time.…”

Section: Benefits Vs Toxicity Of Eosmentioning

confidence: 99%

Essential Oils in Wellness Centers: Overview on European Union Legislation, Potential Therapeutic Effects and Toxicity

Burlec¹

2020

FARMACIA

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Essential oils or volatile oils are natural products that have a large series of uses in the food and cosmetic sectors. According to their intended use, essential oils are subjected to various European guidelines that aim to protect the health and safety of consumers. Volatile oils present important biological activities, some of the most known being their antimicrobial properties, but other potential therapeutic indications for such products have been more recently suggested, as well. However, they are not necessarily harmless and can present an important sensitizing potential. Essential oils have been administered through different routes, including inhalations and skin applications, in the treatment of stress and anxiety. Regardless of the rout e of administration, aromatherapy deeply relies on the sense of smell and its connection with the limbic system. Nevertheless, outside of the principles of aromatherapy, numerous scientific studies have revealed their potential beneficial implications in Alzheimer's and other neurological disorders. Rezumat Uleiurile esențiale sau uleiurile volatile sunt produse naturale care au o serie largă de utilizări în sectorul alimentar și în cel cosmetic. În funcție de utilizarea propusă, uleiurile esențiale sunt supuse diferitelor reglementări europene care au ca scop protejarea sănătății și a siguranței consumatorilor. Uleiurile volatile prezintă activități biologice importante, unele dintre cele mai cunoscute fiind proprietățile lor antimicrobiene, dar au fost sugerate și alte potențiale indicații terapeutice pentru astfel de produse. Cu toate acestea, ele nu sunt neapărat inofensive și pot prezenta un potențial de sensibilizare important. Uleiurile esențiale sunt administrate pe diferite căi, incluzând inhalațiile și aplicațiile cutanate, în tratamentul stresului și al anxietății. Indiferent de calea de administrare, aromaterapia se bazează pe simțul mirosului și pe legătura acestuia cu sistemul limbic. Cu toate acestea, în afara principiilor aromaterapiei, numeroase studii științifice au relevat potențialele lor implicații benefice în boala Alzheimer și alte tulburări neurologice.

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Section: Benefits Vs Toxicity Of Eosmentioning

confidence: 99%

Essential Oils in Wellness Centers: Overview on European Union Legislation, Potential Therapeutic Effects and Toxicity

Burlec¹

2020

FARMACIA

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Mining of candidate genes involved in the biosynthesis of dextrorotatory borneol in Cinnamomum burmannii by transcriptomic analysis on three chemotypes

Yang

Liu

et al. 2020

PeerJ

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Background Dextrorotatory borneol (D-borneol), a cyclic monoterpene, is widely used in traditional Chinese medicine as an efficient topical analgesic drug. Fresh leaves of Cinnamomum trees, e.g., C. burmannii and C. camphor, are the main sources from which D-borneol is extracted by steam distillation, yet with low yields. Insufficient supply of D-borneol has hampered its clinical use and production of patent remedies for a long time. Biological synthesis of D-borneol offers an additional approach; however, mechanisms of D-borneol biosynthesis remain mostly unresolved. Hence, it is important and necessary to elucidate the biosynthetic pathway of D-borneol. Results Comparative analysis on the gene expression patterns of different D-borneol production C. burmannii samples facilitates elucidation on the underlying biosynthetic pathway of D-borneol. Herein, we collected three different chemotypes of C. burmannii, which harbor different contents of D-borneol.A total of 100,218 unigenes with an N50 of 1,128 bp were assembled de novo using Trinity from a total of 21.21 Gb clean bases. We used BLASTx analysis against several public databases to annotate 45,485 unigenes (45.38%) to at least one database, among which 82 unigenes were assigned to terpenoid biosynthesis pathways by KEGG annotation. In addition, we defined 8,860 unigenes as differentially expressed genes (DEGs), among which 13 DEGs were associated with terpenoid biosynthesis pathways. One 1-deoxy-D-xylulose-5-phosphate synthase (DXS) and two monoterpene synthase, designated as CbDXS9, CbTPS2 and CbTPS3, were up-regulated in the high-borneol group compared to the low-borneol and borneol-free groups, and might be vital to biosynthesis of D-borneol in C. burmannii. In addition, we identified one WRKY, two BHLH, one AP2/ERF and three MYB candidate genes, which exhibited the same expression patterns as CbTPS2 and CbTPS3, suggesting that these transcription factors might potentially regulate D-borneol biosynthesis. Finally, quantitative real-time PCR was conducted to detect the actual expression level of those candidate genes related to the D-borneol biosynthesis pathway, and the result showed that the expression patterns of the candidate genes related to D-borneol biosynthesis were basically consistent with those revealed by transcriptome analysis. Conclusions We used transcriptome sequencing to analyze three different chemotypes of C. burmannii, identifying three candidate structural genes (one DXS, two monoterpene synthases) and seven potential transcription factor candidates (one WRKY, two BHLH, one AP2/ERF and three MYB) involved in D-borneol biosynthesis. These results provide new insight into our understanding of the production and accumulation of D-borneol in C. burmannii.

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Mésusage traditionnel du camphre: un danger oublié pour les enfants (à propos de 2 cas)

Cited by 2 publications

References 7 publications

Essential Oils in Wellness Centers: Overview on European Union Legislation, Potential Therapeutic Effects and Toxicity

Essential Oils in Wellness Centers: Overview on European Union Legislation, Potential Therapeutic Effects and Toxicity

Mining of candidate genes involved in the biosynthesis of dextrorotatory borneol in Cinnamomum burmannii by transcriptomic analysis on three chemotypes

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