Messung der Magenwanddurchblutung beim Hund mit radioaktiven Microspheres nach trunculärer Vagotomie

Lenz, J; Seifert, J.; Brendel, W.; Holle, F

doi:10.1007/978-3-642-66615-5_41

Cited by 6 publications

(5 citation statements)

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“…However, in our study, a reduced blood flow was probably not a predetermining factor because NRC was unchanged under resting conditions and comparable to resting flow in volunteers. Investigations in animals, using microspheres [19] or SSKr [20], showed that immediately after vagal section there was a 35-50% fall in basal blood flow, paralleling the fall in acid secretion. Studies made 3 weeks after vagotomy showed that blood flow had returned to normal basal levels, whereas acid secretion remained reduced [21,22].…”

Section: Significance Of Blood Flow Changes After Vagotomymentioning

confidence: 99%

“…The concept of "No acid: No ulcer" first propounded by Schwartz in 1910 [1] still guides the clinician to reduce gastric output in the treatment of peptic ulcer disease. However, the idea that acid is central to the pathogenesis and treatment of this group of A preliminary account of the studies in patients was presented at the meeting "Verdict on Vagotomy," February [16][17][18][19]1981, Basel, Switzerland. diseases has helped but little in the understanding of the cause, which may indicate the coalescence of many factors.…”

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confidence: 99%

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Basal and dose‐response studies of gastric mucosal blood flow: Comparison of duodenal ulcer patients before and after highly selective vagotomy with normal volunteers

et al. 1982

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Gastric mucosal blood flow (neutral red clearance, NRC) and acid secretion were measured before and after highly selective vagotomy (HSV). Eleven patients with duodenal ulcer were studied before and 12–21 days after HSV. Eight volunteers were also studied using the histamine‐H2‐receptor antagonists cimetidine and ranitidine. Basal secretion was collected for 40–50 minutes and pentagastrin was given in increasing doses each for 40 minutes. Data were analyzed using Wilcoxon's signed‐ranks test for paired samples and an analysis of covariance. Basal NRC was similar both for patients and for volunteers and was unaffected by HSV. There was a linear correlation between NRC and acid output. The patients with duodenal ulcer had a lower ratio of NRC to acid during pentagastrin stimulation than was found in normal subjects, but the regression line after HSV was comparable to that found for the volunteers. Although stimulated acid output was reduced by HSV, NRC was significantly higher after HSV than before. The 2 histamine‐H2‐receptor antagonists reduced both NRC and acid to a similar extent, and this could not be overcome by increasing the dose of pentagastrin. These results indicate that mucosal blood flow and acid secretion may not be unconditionally linked, although a linear relationship was always found. HSV produces an effect on blood flow that is not linked to the reduction in acid output.

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Section: Significance Of Blood Flow Changes After Vagotomymentioning

confidence: 99%

mentioning

confidence: 99%

Basal and dose‐response studies of gastric mucosal blood flow: Comparison of duodenal ulcer patients before and after highly selective vagotomy with normal volunteers

et al. 1982

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“…For the determination of blood flow in the gastrointestinal tract the microsphere technique according to the method of Rudolf and Heymann [10] is very suitable, because it is possible to record blood flow changes not only under various physiopathological conditions [1,2,3,11], but also in different regions and layers of the stomach [6,7,8]. Blood flow measurements after selective proximal vagotomy were performed 3 weeks after the operation.…”

Section: Discussionmentioning

confidence: 99%

Are bloodflow changes after selective proximal vagotomy responsible for a necrosis in the gastric wall?

et al. 1980

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Animal experiments were performed to investigate bloodflow distribution before and after selective vagotomy to explain gastric mucosa necrosis found in some patients after vogtomy. Flow measurements were made using the microsphere technique. Changes in the microcirculation were determined under basal and stimulated conditions (250 mg 2-desoxy-D-glucose). After selective vagotomy a reduction in bloodflow of up to 50% could be observed in all layers of the stomach. There were no differences in the bloodflow along either the lesser or greater curvature under basal conditions. In the stimulated stomach, however, the increase in bloodflow along the lesser curvature was higher, although the vessels of this region were mostly altered by SPV operative procedure. From these results it can be concluded that a reducton of arterial input after selective proximal vagotomy is probably compensated for by intramucosal or submucosal anastomoses. Therefore, necrosis in the gastric wall is not due to SPV but probably to other accompanying diseases.

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“…During injection of microspheres a reference sample was withdrawn out of the femoral artery. By means of this technique it was also possible to estimate changes of the cardiac output (Lenz;Brendel & Halle, 1977) (Fig. I).…”

Section: Methodsmentioning

confidence: 99%

Microcirculation and blood volume in rats before and after spinal cord injury

et al. 1979

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Messung der Magenwanddurchblutung beim Hund mit radioaktiven Microspheres nach trunculärer Vagotomie

Cited by 6 publications

References 1 publication

Basal and dose‐response studies of gastric mucosal blood flow: Comparison of duodenal ulcer patients before and after highly selective vagotomy with normal volunteers

Basal and dose‐response studies of gastric mucosal blood flow: Comparison of duodenal ulcer patients before and after highly selective vagotomy with normal volunteers

Are bloodflow changes after selective proximal vagotomy responsible for a necrosis in the gastric wall?

Microcirculation and blood volume in rats before and after spinal cord injury

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