Mesothelioma in Quebec chrysotile miners and millers: Epidemiology and aetiology

McDonald, Alison D.; Case, Bruce W.; Churg, Andrew; Dufresne, A.; Gibbs, Graham W.; Sébastien, P.; Jc, McDonald

doi:10.1016/s0003-4878(97)00020-3

Cited by 92 publications

(60 citation statements)

References 19 publications

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“…Although several reports 16,17) on the case of malignant pleural mesothelioma demonstrate low density exposure over a prolonged period of time (more than 40 yr), our study shows a different view on the tumor since we reveal a higher density exposure but a shorter period of exposure time. Also due to the evidence of the great concentration of asbestos bodies and fibers in the lungs, our study shows that, though exposure to asbestos was for a shorter period, it resulted in a much greater intensity and high density in relationship to time exposed.…”

Section: Discussioncontrasting

confidence: 91%

Malignant Pleural Mesothelioma in Parts of Japan in Relationship to Asbestos Exposure

et al. 2004

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Malignant pleural mesothelioma is induced by asbestos exposure. Many reports have described this situation in America and European countries, but a few have been published in Japan. In this study malignant pleural mesothelioma cases in hospitals located in an area facing the Seto Inland Sea were evaluated. A total of 106 patients were examined with 100 patients having had occupational exposure to asbestos and 6 patients without such histories of asbestos exposure. Ninety seven were male and 9 were female. Ages ranged from 41 to 87 yr with mean of 64.8 ± 5.3 yr. Thirty seven cases showed epithelial type of tumor, 25 biphasic type and 15 showed sarcomatous. The remaining 23 cases had insufficient evidence for typing the tumor. The mean survival rate for all cases was 9.2 ± 11.6 months. Fifty-one patients had occupational histories of shipyard work, 16 patients worked in asbestos cement piping, and the remainder were employed in miscellaneous jobs related asbestos exposure. The duration of asbestos exposure ranged up to 20 yr or longer with the mean of 17.2 ± 8.9 yr and the average latent period for the occurrence of malignant pleural mesothelioma was more than 31 yr with the mean of 37.0 ± 13.3 yr. Quantification of asbestos bodies in the lungs indicated a high concentration in most patients and the major types of asbestos fibers were crocidolite and amosite. Six cases appeared after exposure to chrysotile. These results indicated that ninety four percent of malignant pleural mesothelioma appeared due to the exposure to asbestos including crocidolite and amosite. The remainder may be blamed on exposure to chrysotile.

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Section: Discussioncontrasting

confidence: 91%

Malignant Pleural Mesothelioma in Parts of Japan in Relationship to Asbestos Exposure

et al. 2004

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“…"The presence of eight cases of peritoneal mesothelioma in the study population (SIR=25.04 (CI 10.78-49.33) confirmed the significantly elevated incidence of these cancers for both genders" [41]. The results agree with an American study [42,43] which compiled all cases peritoneal mesothelioma from 1973 to 1984 and in which the percentage of cases in women was higher than in men. This finding is contrary to other studies that claim a lesser causal relationship between asbestos exposure and peritoneal mesothelioma in women as compared to men [20].…”

Section: Occupational Cohortssupporting

confidence: 81%

“…This finding is contrary to other studies that claim a lesser causal relationship between asbestos exposure and peritoneal mesothelioma in women as compared to men [20]. There have been other reports of peritoneal mesotheliomas in occupational groups exposed to chrysotile asbestos from all over the world including China [44,45] Italy [46,47] Australia [48] and Canada [42,49].…”

Section: Occupational Cohortscontrasting

confidence: 62%

Peritoneal Mesothelioma and Asbestos: Clarifying the Relationship by Epidemiology

Kanarek¹,

Mandich²

2016

Epidemiology

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Peritoneal mesothelioma has been recognized for over a half century, but causality with asbestos of different fiber types and the incidence of this fatal tumor in relation to asbestos exposure dose still needs clarification. In order to help bring clarity, the most important studies on peritoneal mesothelioma, including a brief history, relationship to asbestos exposures, diagnostic issues and experimental studies are reviewed including case series, case-control, occupational, and registry epidemiology studies. This review concludes that all types of asbestos, including amphiboles and chrysotile, are causative for peritoneal mesothelioma. Many cases have been found in both males and females from asbestos exposures in occupational and neighborhood settings, shown in differing epidemiology study designs. It is clear that there is a causal relationship between all types of asbestos at all dose levels for peritoneal mesothelioma and no threshold of exposure to asbestos appears safe.

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“…Few workers have been exposed only to chrysotile, most historical exposure measurements were of particles rather than fibres, and the interpretation of lung burden studies is complicated by the rapid pulmonary clearance of chrysotile. The controversy has focused on the Quebec chrysotile miners and millers (Liddell et al, 1997;McDonald et al, 1997). The ratio of mesothelioma to excess lung cancer was about 1:4, but the authors attributed most of the 38 mesotheliomas to contamination with tremolite, and concluded that exposure below 300 million particles per cubic footÐyears, which was stated to be equivalent to 10 years at 80 fibre ml Ð1 , was virtually innocuous.…”

Section: Discussionmentioning

confidence: 99%

The European mesothelioma epidemic

et al. 1999

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Summary Projections for the period 1995-2029 suggest that the number of men dying from mesothelioma in Western Europe each year will almost double over the next 20 years, from 5000 in 1998 to about 9000 around 2018, and then decline, with a total of about a quarter of a million deaths over the next 35 years. The highest risk will be suffered by men born around 1945-50, of whom about 1 in 150 will die of mesothelioma. Asbestos use in Western Europe remained high until 1980, and substantial quantities are still used in several European countries. These projections are based on the fit of a simple age and birth cohort model to male pleural cancer mortality from 1970 to 1989 for six countries (Britain, France, Germany, Italy, The Netherlands and Switzerland) which together account for three-quarters of the population of Western Europe. The model was tested by comparing observed and predicted numbers of deaths for the period 1990-94. The ratio of mesothelioma to recorded pleural cancer mortality has been 1.6:1 in Britain but was assumed to be 1:1 in other countries.

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Mesothelioma in Quebec chrysotile miners and millers: Epidemiology and aetiology

Cited by 92 publications

References 19 publications

Malignant Pleural Mesothelioma in Parts of Japan in Relationship to Asbestos Exposure

Malignant Pleural Mesothelioma in Parts of Japan in Relationship to Asbestos Exposure

Peritoneal Mesothelioma and Asbestos: Clarifying the Relationship by Epidemiology

The European mesothelioma epidemic

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