Mesothelioma following Exposure to Asbestos: A Review of 72 Cases

Borow, M; Conston, Alfred S.; Livornese, Lawrence; Schalet, Norbert

doi:10.1378/chest.64.5.641

Cited by 111 publications

(30 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…, Yang-Kyu CHOI 2) , Hwa-Young YOON 3) , Oh-Kyeong KWEON 4) and Dae-Yong KIM 1) * 1) Departments of Pathology, 3) Mesotheliomas are neoplasms of the serous lining mesothelial cells of the abdominal, thoracic, and pleural cavities [4,6]. Spontaneous malignant mesotheliomas are rare, but sporadic cases have been documented in various animal species [4,6].…”

mentioning

confidence: 99%

Juvenile Malignant Mesothelioma in a Dog.

Kim

Choi

Yoon

et al. 2002

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. An 11-month-old male mixed breed dog was euthanized due to two months history of vomiting and anorexia. At necropsy, numerous, multifocal or coalescing, firm, protruding nodules, 5 to 40 mm in diameter were scattered throughout the mesentery and omentum. Histologically and immunohistochemically, the nodules were diagnosed as malignant mesothelioma. Metastasis to the regional mesenteric, mediastinal and tracheobronchial lymph nodes were observed.KEY WORDS: canine, mesothelioma, neoplasia.J. Vet. Med. Sci. 64(3): 269-271, 2002 Mesotheliomas are neoplasms of the serous lining mesothelial cells of the abdominal, thoracic, and pleural cavities [4,6]. Spontaneous malignant mesotheliomas are rare, but sporadic cases have been documented in various animal species [4,6]. They occur most frequently as a congenital tumor in calves, but the age of onset is 4 to 13 years (mean 7.8 years) in canine [4]. Experimentally induced mesotheliomas have been reported in non-human primates and rodents following intratracheal exposure to asbestos fibers or cigarette smoke [2,3]. Mesotheliomas in animals are divided into epithelial and sclerosing types based on the histologic patterns of the neoplasm [4,6]. In the present report, we document a case of canine juvenile mesothelioma.An 11-month-old female mixed breed dog was admitted to the Seoul National University Veterinary Teaching Hospital after two months history of intermittent vomiting, anorexia, and weight loss. Pleural effusion, ascites, and abdominal masses were revealed upon explorative laparotomy. Because of the poor prognosis, the dog was euthanized, and postmortem examination was performed.At necropsy, the abdominal cavity contained a large amount of serosangineous fluid. Numerous, multifocal or often confluent, tan to white, firm, protruding nodules, 5 to 40 mm in diameter, were scattered throughout the mesentery, omentum, and serosal surfaces of the abdominal organs giving a characteristic velvety appearance (Fig. 1). Mesenteric lymph nodes were enlarged about two to four times their normal sizes. In pleural cavity, mediastinal and tracheobronchial lymph nodes were enlarged but no neoplastic nodule as seen in the abdominal cavity was found on pleural surface.Tissue samples from the abdominal tumor nodules and representative tissue specimens were fixed in 10% phosphate-buffered formalin, routinely processed, and stained with hematoxylin and eosin (H&E) for light microscopic examination. Replicate sections of the tumor masses were

show abstract

mentioning

confidence: 99%

Juvenile Malignant Mesothelioma in a Dog.

Kim

Choi

Yoon

et al. 2002

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

show abstract

“…3,14 It progresses locally with metastases occurring in only the latest stages of disease. As such, it makes an attractive theoretical target for locally administered gene -based therapies.…”

Section: Discussionmentioning

confidence: 99%

“…2 Mesothelioma presents clinically with tumors involving the parietal or visceral pleura or, less commonly, the parietal peritoneum. 3 Because of the anatomical location of these cancers within a body cavity, these tumors have presented attractive targets for intracavitary gene therapy. Currently, gene therapy approaches using direct instillation of viral vectors into the pleural cavity in mesothelioma are being carried out.…”

mentioning

confidence: 99%

Gene therapy of established mesothelioma xenografts with recombinant p16INK4a adenovirus

et al. 2000

View full text Add to dashboard Cite

“…All but one had been exposed to asbestos. Since then, there has been a steady increase in reports of malignant mesothelioma, particularly among persons with environmental or occupational exposure to asbestos [10,11]. In animal studies, the intraperitoneal injection of nickel, silicon, zeolite, chryso tile, crocidolite, amosite and tremolite has produced malignant mesothelioma [12].…”

Section: Discussionmentioning

confidence: 99%