Mesothelioma due to environmental exposure to erionite in Turkey

Dikensoy, Öner

doi:10.1097/mcp.0b013e3282fcea65

Cited by 33 publications

(17 citation statements)

References 31 publications

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“…• Amphibole asbestos (crocidolite, amosite, tremolite, anthophyllite, actinolite) [74] • Serpentine asbestos (Chrysotile) [75] • Erionite [76] • Iron saccharate [77] Environmental factors of unclear carcinogenic potential • Silica [78] • Carbon nanotubes [79] • Synthetic fibers, ceramic fibre, wool and glass fibers [80] • Hundreds of naturally occurring fibers [81] REviEW Robinson …”

Section: Proven Carcinogens For Mesotheliomamentioning

confidence: 96%

Mouse Models of Mesothelioma: Strengths, Limitations and Clinical Translation

et al. 2014

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These authors contributed equally SUMMARY Mouse models of cancer are invaluable for obtaining detailed knowledge about tumor development and for screening therapeutic and preventive approaches. Mesothelioma is an unusual cancer because the same carcinogen, asbestos, causes a similar disease in both humans and animals. Unlike most other cancers, murine mesothelioma can therefore be regarded as a disease homolog, rather than a model as such. However, because asbestos-induced cancer has low penetrance and a long lag time, most translational studies have utilized more efficient models such as tumor transplantation. In consequence, many promising results have not translated into positive findings in patients. Here, we describe the widely used murine mesothelioma models and critically discuss their relative advantages and disadvantages. We emphasize the use of the appropriate model for the specific research question and the need to use multiple models in order to obtain robust and translatable data.

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Section: Proven Carcinogens For Mesotheliomamentioning

confidence: 96%

Mouse Models of Mesothelioma: Strengths, Limitations and Clinical Translation

et al. 2014

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“…Chrysotile, amphibole asbestos and fibrous erionite have all been classified as carcinogenic substances (Kane, 1996;Dikensoy, 2008;Gualtieri, 2012). Worldwide, there is universal consensus on the toxicity and carcinogenicity of amphibole asbestos whereas debate still regards chrysotile asbestos, which is considered less toxic than fibrous amphiboles.…”

Section: Introductionmentioning

confidence: 98%

Trace elements in hazardous mineral fibres

Bloise

Barca

Gualtieri

et al. 2016

Environmental Pollution

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Both occupational and environmental exposure to asbestos-mineral fibres can be associated with lung diseases. The pathogenic effects are related to the dimension, biopersistence and chemical composition of the fibres. In addition to the major mineral elements, mineral fibres contain trace elements and their content may play a role in fibre toxicity. To shed light on the role of trace elements in asbestos carcinogenesis, knowledge on their concentration in asbestos-mineral fibres is mandatory. It is possible that trace elements play a synergetic factor in the pathogenesis of diseases caused by the inhalation of mineral fibres. In this paper, the concentration levels of trace elements from three chrysotile samples, four amphibole asbestos samples (UICC amosite, UICC anthophyllite, UICC crocidolite and tremolite) and fibrous erionite from Jersey, Nevada (USA) were determined using inductively coupled plasma mass spectrometry (ICP-MS). For all samples, the following trace elements were measured: Li, Be, Sc, V, Cr, Mn, Co, Ni, Cu, Zn, As, Rb, Sr, Y, Sb, Cs, Ba, La, Pb, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Th, U. Their distribution in the various mineral species is thoroughly discussed. The obtained results indicate that the amount of trace metals such as Mn, Cr, Co, Ni, Cu and Zn is higher in anthophyllite and chrysotile samples, whereas the amount of rare earth elements (REE) is higher in erionite and tremolite samples. The results of this work can be useful to the pathologists and biochemists who use asbestos minerals and fibrous erionite in-vitro studies as positive cyto- and geno-toxic standard references.

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“…To date, asbestos and erionite fibres are the only recognised risk factors for pleural mesothelioma 1 2…”

Section: Introductionmentioning

confidence: 99%