Mesothelin expression correlates with elevated inhibitory immune activity in patients with colorectal cancer
Midhun malla,
Sachin Kumar Deshkmukh,
Sharon Wu
et al.
Abstract:The expression of the protein Mesothelin (MSLN) is highly variable in several malignancies including colorectal cancer (CRC) and high levels are associated with aggressive clinicopathological features and worse patient survival. CRC is both a common and deadly cancer; being the third most common in incidence and second most common cause of cancer related death. While systemic therapy remains the primary therapeutic option for most patients with stage IV (metastatic; m) CRC, their disease eventually becomes tre… Show more
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