Mesothelin- and nucleolin-specific T cells from combined short peptides effectively kill triple-negative breast cancer cells
Suyanee Thongchot,
Krittaya Aksonnam,
Jaturawitt Prasopsiri
et al.
Abstract:Background
Triple-negative breast cancer (TNBC), known for its aggressiveness and limited treatment options, presents a significant challenge. Adoptive cell transfer, involving the ex vivo generation of antigen-specific T cells from peripheral blood mononuclear cells (PBMCs), emerges as a promising approach. The overexpression of mesothelin (MSLN) and nucleolin (NCL) in TNBC samples underscores their potential as targets for T cell therapy. This study explored the efficacy of multi-peptide puls… Show more
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