Mesothelial stomata overlying omental milky spots: Scanning electron microscopic study

Mironov, V. A.; Гусев, С. А.; Baradi, A. F.

doi:10.1007/bf00235068

Cited by 69 publications

(45 citation statements)

References 7 publications

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“…Recently, Shimotsuma and colleagues [5] 20-40/cm2 and gradually decreases to 5-14/cm2 at 3-10 years of age, and less than 5/cm2 at 10-78 years ofage [6]. Mesothelial stomata overlying omental milky spots allow milky spot lymphocytes to enter and possibly also to leave the peritoneal cavity [7]. These data suggest that milky spot cells play a role in the immunological defence ofthe peritoneal cavity.…”

Section: Introductionmentioning

confidence: 95%

“…route. The AbSC were probably derived from the circulation through migration to milky spots via omental stomata [7]. [11].…”

Section: Total Immunoglobulin Levelsmentioning

confidence: 99%

“…The regular CAPD schedule was resumed after 8 h. Four subjects served as controls and received one 0 5-ml dose of the TT vaccine intramuscularly in the deltoid muscle. Blood, saliva, and peritoneal effluents (the overnight dialysate) were obtained before, 7,14, and 21 days after immunization.…”

Section: Immunizationmentioning

confidence: 99%

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Intraperitoneal immunization of human subjects with tetanus toxoid induces specific antibody-secreting cells in the peritoneal cavity and in the circulation, but fails to elicit a secretory IgA response

Lue

Bake

Prince

et al. 1994

Clinical and Experimental Immunology

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SUMMARYFive patients on continuous ambulatory peritoneal dialysis (CAPD) were immunized intraperitoneally with tetanus toxoid (TT) through an indwelling catheter. Four control patients on CAPD received the same dose of TT intramuscularly. Before immunization, virtually no anti-TT antibodysecreting cells (AbSC) were detected by the enzyme-linked immunospot (ELISPOT) assay in peripheral blood or peritoneal fluid from patients ofeither group. One to 2 weeks after immunization, high frequencies of TT-specific AbSC were detected in the circulation and peritoneal cavity. More than 80% of those cells were of the IgG isotype, with IgA accounting for most of the remainder. Patients receiving TT by the i.p. route showed significantly higher frequencies of specific IgG and IgA AbSC in the peritoneal cavity than patients immunized intramuscularly. Frequencies of AbSC in peripheral blood did not significantly differ between the two groups. Immunization with TT by both routes resulted in a significant increase of IgG anti-TT antibodies in serum, saliva and peritoneal fluid. A significant IgA antibody response was seen only in serum and peritoneal effluents. Therefore, i.p. immunization of human subjects with TT elicited both a localized response in the peritoneal cavity as well as a systemic response in serum, but did not induce a salivary IgA response.

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Section: Introductionmentioning

confidence: 95%

“…route. The AbSC were probably derived from the circulation through migration to milky spots via omental stomata [7]. [11].…”

Section: Total Immunoglobulin Levelsmentioning

confidence: 99%

See 1 more Smart Citation

Intraperitoneal immunization of human subjects with tetanus toxoid induces specific antibody-secreting cells in the peritoneal cavity and in the circulation, but fails to elicit a secretory IgA response

Lue

Bake

Prince

et al. 1994

Clinical and Experimental Immunology

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“…( 10]. using scanning electron microscopy, showed fenestrations in the mesothelial lining of the dia phragmatic pleura and the omental milky spots.…”

Section: Discussionmentioning

confidence: 99%

The Milky Spots on the Chest Wall in Newborns

Aharinejad

Franz²,

Firbas³

1990

Cells Tissues Organs

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“…A number of morphologic studies on stomata were made at the electron-microscopic level [5,[7][8][9], How ever. no articles about stomata on the human diaphrag matic peritoneum were published.…”

Section: Discussionmentioning

confidence: 99%

Study on the infrastructure of the Peritoneal Stomata in Humans

Ji-Chang¹,

Yu²

1991

Cells Tissues Organs

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In 16 human specimens the topography and organization of stomata and mèsothelial cells of the diaphragmatic, pelvic wall and anterior abdominal wall peritoneum were studied by transmission electron microscopy, scanning electron microscopy and the image processing technique. The mesothelial cells were organized into two discrete populations, cuboidal cells and flattened cells. The stomata were found only among cuboidal cells, either on the muscular portion or on the tendinous portion of the diaphragm. The size and shape of stomata, which were arranged in a cluster or a strip were often irregular. The average area of a stoma on the muscular portion was 10.43 ± 1.61 µm² on the tendinous portion 7.93 ± 1.67 µm². Stomata opened to submesothelial connective tissue, under which numerous lymphatics were observed. Stomata were not discovered in the pelvic and anterior abdominal wall peritoneum. In animal experiments intraperitoneally injected trypan blue particles were rapidly removed from the peritoneal cavity through stomata of the diaphragmatic peritoneum in rabbits. It is suggested that stomata may be the main pathway for draining matter from the peritoneal cavity and that the diaphragmatic peritoneum shows the strongest absorption in all parts of the peritoneum.

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Mesothelial stomata overlying omental milky spots: Scanning electron microscopic study

Cited by 69 publications

References 7 publications

Intraperitoneal immunization of human subjects with tetanus toxoid induces specific antibody-secreting cells in the peritoneal cavity and in the circulation, but fails to elicit a secretory IgA response

Intraperitoneal immunization of human subjects with tetanus toxoid induces specific antibody-secreting cells in the peritoneal cavity and in the circulation, but fails to elicit a secretory IgA response

The Milky Spots on the Chest Wall in Newborns

Study on the infrastructure of the Peritoneal Stomata in Humans

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