Mesothelial/monocytic incidental cardiac excrescences (MICE): report of a case and review of literature with focus on pathogenesis

Girolami, Ilaria; Eccher, Albino; Gilioli, Eliana; Novelli, Luca; Stefano, Gioia Di; Brunelli, Matteo; Cima, Luca

doi:10.1016/j.carpath.2018.06.001

Cited by 8 publications

(14 citation statements)

References 28 publications

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“…The present case features the classical intraoperative and pathological features of MICE, with location, gross appearance, dimension, and histological characteristics mostly described in the literature, but without any previous cardiac invasive procedure. The patient suffered from UCTD with several autoantibody positivities and vascular thrombosis while pregnant.…”

Section: Discussionsupporting

confidence: 53%

“…MICE is equally distributed among males and females, mainly involving individuals older than 60 . To date, approximately 50 cases have been reported in the literature and its etiology remains controversial . The “reactive” pathogenetic theory emphasizes the role of mechanical irritation or inflammation as triggers for the formation.…”

Section: Introductionmentioning

confidence: 99%

“…1 To date, approximately 50 cases have been reported in the literature and its etiology remains controversial. 2 The "reactive" pathogenetic theory emphasizes the role of mechanical irritation or inflammation as triggers for the formation. Luthringer et al 3 suggested that a possible mechanism is ingrowth of pericardial mesothelial cells along a perforation tract caused by cardiac catheterization.…”

Section: Introductionmentioning

confidence: 99%

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Mesothelial/monocytic incidental cardiac excrescence in autoimmune disease

et al. 2019

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Mesothelial/monocytic incidental cardiac excrescence (MICE) is a rare benign finding made of mesothelial cells, histiocytes, and fibrin, usually found during heart valve surgery. The clinical relevance resides in the potential misdiagnosis as metastatic carcinoma or arterial embolism. The pathogenesis remains uncertain, with artifactual and reactive hypotheses. Here we present a case of MICE with paradigmatic clinical, imaging, and histological features in a 28‐year‐old woman with undifferentiated connective tissue disease without previous cardiac catheterization with possible pathogenesis, highlighting the importance of awareness of the existence of this lesion in patients with autoimmune disease.

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Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mesothelial/monocytic incidental cardiac excrescence in autoimmune disease

et al. 2019

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“…There are fewer than 50 cases of MICE reported, with approximately 16% associated with a history of acute rheumatic fever or confirmed RHD, predominantly in young adults and occurring within the heart or pericardial sac. 3 Here we present a case of MICE masquerading as a mediastinal lymph node in a teenage patient with suspected acute RHD.…”

mentioning

confidence: 94%

“…There have been nine cases reported, including the current case, of MICE identified in patients with a prior rheumatic fever or confirmed RHD. 3 These patients averaged 35 years of age, with a range from 17 to 66 years. The male:female ratio was 4:5.…”

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confidence: 99%