Mesothelial derived adenomatoid tumour in a location devoid of mesothelium: adrenal adenomatoid tumour

Sağlıcan, Yeşim; Kurtulmuş, Neslihan; Tunca, Fatih; Süleyman, Erdoğan

doi:10.1136/bcr-2015-211147

Cited by 7 publications

(5 citation statements)

References 5 publications

(3 reference statements)

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“…Except for 4 patients who were not available, lymphocytic infiltration or aggregation was observed in 27 patients and not reported in 10 patients. [2–31]…”

Section: Discussionmentioning

confidence: 99%

Primary adenomatoid tumor of the adrenal gland: A case report and literature review

Qi,

Chen,

Yang

et al. 2023

Medicine

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Rationale: Adenomatoid tumors are rare benign tumors, mainly involving the reproductive tract, such as the epididymis in men and the uterus and fallopian tubes in women. However, a few cases can occur outside the reproductive tract. Herein, we report a rare case of a primary adenomatoid tumor of the adrenal gland. Patient concerns: A 50-year-old man underwent ultrasound examination and was found to have a right adrenal mass without elevated blood pressure, weakness after fatigue, frequent nocturnal urination urgency, pain, or a history of hematuria. The patient’s general health was normal. Computed tomography revealed a polycystic mixed-density lesion in the right adrenal region, approximately 7.3 × 4.5 cm in size. Diagnoses: Based on the clinical information, morphological features, and immunohistochemistry results, a pathological diagnosis of primary adenomatoid tumor of the adrenal gland was made. Intervention: Excision of the right adrenal gland and tumor through the 11 ribs. Outcomes: The patient’s postoperative course was uneventful. Lessons: Preventing misdiagnosis adenomatoid tumors with other types of adrenal gland tumors or metastatic tumors is imperative. Morphological and immunohistochemical features can help diagnose primary adenomatoid tumors of the adrenal gland.

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“…Except for 4 patients who were not available, lymphocytic infiltration or aggregation was observed in 27 patients and not reported in 10 patients. [2–31]…”

Section: Discussionmentioning

confidence: 99%

Primary adenomatoid tumor of the adrenal gland: A case report and literature review

Qi,

Chen,

Yang

et al. 2023

Medicine

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“…In the solid structure, the tumor cells are epithelioid with eosinophilic cytoplasm, and signet-ring-like cells always can be seen. The papillary patterns are uncommon which are covered by flat or cuboidal cells ( 3 , 7 , 9 , 29 ). There is no cellular atypia, pathological mitosis, or necrosis.…”

Section: Discussionmentioning

confidence: 99%

Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature

Guan

Zhao

et al. 2021

Front. Endocrinol.

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Adenomatoid tumor (AT) is an uncommon benign neoplasm of mesothelial origin, usually occurring in the female and male genital tracts. Extragenital localization such as the adrenal gland is extremely rare. Until now, only 39 cases of adrenal AT have been reported in the English literature. Here we report two novel cases of adrenal AT that occurred in male patients aged 30 and 31 years. The tumors were discovered incidentally by computed tomography (CT). Macroscopically, the tumors were unilateral and solid, and the greatest dimension of the tumors was 3.5 and 8.0 cm, respectively. Histologically, the tumors consisted of angiomatoid, cystic, and solid patterns and infiltrated the adrenal cortical or medullary tissue. The tumor cells had low nuclear/cytoplasmic ratio, with no pathological mitosis or nuclear pleomorphism. Thread-like bridging strands and signet-ring-like cells could be seen. Immunohistochemically, the tumor cells were positive for epithelial markers (AE1/AE3, CK7) and mesothelial markers (D2-40, calretinin, and WT-1). The Ki-67 index was approximately 1 and 2%, respectively. The differential diagnosis of adrenal AT includes a variety of benign and malignant tumors. The patients had neither local recurrence nor distant metastasis at 21 and 8 months after removal of the tumor. In the literature review, we comprehensively summarized the clinical, morphological, immunohistochemical, and prognostic features of adrenal AT. Adrenal ATs are morphologically and immunophenotypically identical to those that occur in the genital tracts. Combining the histology with immunohistochemical profiles is very supportive in reaching the diagnosis of this benign tumor, helping to avoid misdiagnosis and overtreatment.

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“…Depending on the anatomic site its name differs: pleura (lining the lungs and chest wall), peritoneum (lining the abdominal organs and wall), pericardium (lining the heart) and tunica vaginalis (lining the testes). Adenomatoid tumors usually occur in the genital tract of both sexes and less frequently in heart, 2 mediastinum, 3‐5 pancreas, 6 liver, 7‐12 pleura, 13 mesocolon, 14 omentum, 14‐16 lymph node, 17 peritoneum, 9,18 intestinal mesentery, 19 adrenal glands, 20‐55 and skin 56 . Most tumors are discovered incidentally.…”

Section: Discussionmentioning

confidence: 99%

Adenomatoid tumor of the skin: Differential diagnosis of an umbilical erythematous plaque

et al. 2020

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Adenomatoid tumors are benign tumors of mesothelial origin that are usually encountered in the genital tract. Although they have been observed in other organs, the skin appears to be a very rare location, with only one case reported in the literature to our knowledge. We report a second case of an adenomatoid tumor, arising in the umbilicus of a 44-year-old woman. The patient presented with an 8-month-old erythematous and firm plaque under the umbilicus. A skin biopsy showed numerous microcystic spaces dissecting a fibrous stroma and lined by flattened to cuboidal cells with focal intraluminal papillary formation. This little-known diagnosis constitutes a diagnostic pitfall for dermatopathologists and dermatologists, and could be misdiagnosed as other benign or malignant entities. Through this case report, a practical approach and diagnostic keys have been devised to avoid misdiagnosis and overtreatment.

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Mesothelial derived adenomatoid tumour in a location devoid of mesothelium: adrenal adenomatoid tumour

Cited by 7 publications

References 5 publications

Primary adenomatoid tumor of the adrenal gland: A case report and literature review

Primary adenomatoid tumor of the adrenal gland: A case report and literature review

Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature

Adenomatoid tumor of the skin: Differential diagnosis of an umbilical erythematous plaque

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