Mesostriatal and mesolimbic projections of midbrain neurons immunoreactive for estrogen receptor beta or androgen receptors in rats

Creutz, Lela M.; Kritzer, Mary F.

doi:10.1002/cne.20229

Cited by 121 publications

(86 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, expression of ERα is greater than ERβ in the ventromedial hypothalamus and pituitary. Moreover, ERβ expression is more predominant than ERα in the cerebral cortex, hippocampus, anterior olfactory nucleus, dorsal raphe, substantia nigra, midbrain ventral tegmental area, and cerebellum [44,45,69]. This distribution of ERα and ERβ, which is overlapping but also shows distinct differences in expression, has substantiated investigation of whether there are functional effects associated with actions at ERα versus ERβ.…”

Section: Erβ-mediated Actions In the Hippocampus For E 2 'S Functionamentioning

confidence: 95%

Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen

Walf

Frye

2008

Steroids

View full text Add to dashboard Cite

The steroid hormone, estradiol (E 2 ), has numerous targets in the central nervous system, including the hippocampus, which plays a key role in cognition and affective behavior. This review focuses on our evidence from studies in rodents that E 2 has diverse mechanisms in the hippocampus for its functional effects E 2 has rapid, membrane-mediated effects in the hippocampus to enhance cognitive performance. Administration of E 2 to the hippocampus of rats for 10 minutes following training enhances performance in a hippocampus-mediated task. Increased cell firing in the hippocampus occurs within this short time frame. Furthermore, administration of free E 2 or an E 2 conjugate, E 2 :bovine serum albumin (BSA), to the hippocampus produces similar performance-enhancing effects in this task, suggesting that E 2 has membrane actions in the hippocampus for these effects. Further evidence that E 2 has rapid, membrane-mediated effects is that co-administration of E 2 and inhibitors of mitogen activated protein kinase (MAPK), rather than intracellular E 2 receptors (ERs) or protein synthesis, attenuate the enhancing effects of E 2 in this task. Despite these data that demonstrate E 2 can have rapid and/or membrane-mediated effects in the hippocampus, there is clear evidence to suggest that intracellular ERs, particularly the β (rather than α) isoform of ERs, may be important targets for E 2 's functional effects for hippocampal processes. Administration of ligands that are specific for ERβ, but not ERα, have enhancing effects on hippocampal processes similar to that of E 2 (which has similar affinity for ERα and ERβ). These effects are attenuated when ERβ expression is knocked down in transgenic models or with central administration of antisense oligonucleotides. Thus, there may be a convergence of E 2 's actions through rapid, membranemediated effects and intracellular ERs and in the hippocampus for these functional effects.

show abstract

Section: Erβ-mediated Actions In the Hippocampus For E 2 'S Functionamentioning

confidence: 95%

Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen

Walf

Frye

2008

Steroids

View full text Add to dashboard Cite

show abstract

“…The reward value provided by the NAcc requires a biological context signalled by the hormonal state of the female and activated by the release of opioids and DA in the NAcc. It is well established that oestrogen increases synthesis of preproenkephalin (PPE) in the NAcc (LeSaux & Di Paolo 2005), while the dopaminergic projections from the mesolimbic neurons of the midbrain are also immunoreactive for oestrogen receptors (Creutz & Kritzer 2004).…”

Section: Frontal Cortex Enhanced Role In Social Reward For Parentingmentioning

confidence: 99%

Mother–infant bonding and the evolution of mammalian social relationships

Broad

Curley

Keverne

2006

Phil. Trans. R. Soc. B

228

193

View full text Add to dashboard Cite

A wide variety of maternal, social and sexual bonding strategies have been described across mammalian species, including humans. Many of the neural and hormonal mechanisms that underpin the formation and maintenance of these bonds demonstrate a considerable degree of evolutionary conservation across a representative range of these species. However, there is also a considerable degree of diversity in both the way these mechanisms are activated and in the behavioural responses that result. In the majority of small-brained mammals (including rodents), the formation of a maternal or partner preference bond requires individual recognition by olfactory cues, activation of neural mechanisms concerned with social reward by these cues and gender-specific hormonal priming for behavioural output. With the evolutionary increase of neocortex seen in monkeys and apes, there has been a corresponding increase in the complexity of social relationships and bonding strategies together with a significant redundancy in hormonal priming for motivated behaviour. Olfactory recognition and olfactory inputs to areas of the brain concerned with social reward are downregulated and recognition is based on integration of multimodal sensory cues requiring an expanded neocortex, particularly the association cortex. This emancipation from olfactory and hormonal determinants of bonding has been succeeded by the increased importance of social learning that is necessitated by living in a complex social world and, especially in humans, a world that is dominated by cultural inheritance.

show abstract

“…Accordingly, sex hormone levels affect cortical and subcortical brain areas, especially in sensitive periods of development in childhood and adolescence [14]. In this regard, dopaminergic brain areas such as SN, VTA, and hypothalamus are sensitive to the effects of sex hormones because they express estrogens and androgens receptors [7,15,16]. Interestingly, sex hormones induce opposite effects between female and males.…”

Section: Sex Hormones Dopaminergic Neurotransmission and Addictionmentioning

confidence: 99%

“…In this regard, dopaminergic brain areas such as SN, VTA, and hypothalamus are sensitive to the effects of sex hormones because they express estrogens and androgens receptors [7,15,16].…”

Section: Introductionmentioning

confidence: 99%

Sex Hormones: Role in Neurodegenerative Diseases and Addiction

Pinto¹,

Castillo²,

RamónSotomayor-Zárate³

2018

Sex Hormones in Neurodegenerative Processes and Diseases

View full text Add to dashboard Cite

The brain is a complex organ in charge of regulating the homeostasis of our body and behaviors such as motivation, reward, memory, and movement control, between others. These behaviors are regulated by dopaminergic neurons, which can be modulated by several stimuli throughout the life of an individual. For example, early exposure to sex hormones or endocrine disruptors during critical period of neuronal development affects dopaminergic pathways permanently, producing some disorders such as drug addiction. On the other hand, current knowledge regarding neurodegeneration in Parkinson and Alzheimer diseases pointed out the neuroprotection that estradiol can exert, but contradictory information can also be found in the literature. To know the underlying mechanisms that are related to the above mentioned diseases will help to improve health policies and treatments development.

show abstract

Mesostriatal and mesolimbic projections of midbrain neurons immunoreactive for estrogen receptor beta or androgen receptors in rats

Cited by 121 publications

References 77 publications

Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen

Rapid and estrogen receptor beta mediated actions in the hippocampus mediate some functional effects of estrogen

Mother–infant bonding and the evolution of mammalian social relationships

Sex Hormones: Role in Neurodegenerative Diseases and Addiction

Contact Info

Product

Resources

About