Mesoscale Modulation of Supramolecular Ureidopyrimidinone-Based Poly(ethylene glycol) Transient Networks in Water

Kieltyka, Roxanne E.; Pape, Anna-Antonia; Albertazzi, Lorenzo; Nakano, Yoko; Bastings, Maartje M. C.; Voets, Ilja K.; Dankers, Patricia Y. W.; Meijer, E. W.

doi:10.1021/ja403745w

Cited by 87 publications

(104 citation statements)

References 29 publications

Supporting

Mentioning

100

Contrasting

Order By: Relevance

“…The authors studied the rheological behavior of these materials, reported on their intrarenal behavior and tissue response, and proposed possible therapeutic applications. In another seminal work, Meijer and coworkers developed UPy-based dual-fiber networks as a synthetic analogue to fiber formation in the cytoskeleton [157]. For this purpose, mixtures of mono-and bifunctional polymers were used, which a priori form fibers in water; gelation could be achieved by decreasing the pH from 12 to 3.…”

Section: Synthetic Polymersmentioning

confidence: 99%

Supramolecular Polymer Networks: Preparation, Properties, and Potential

Rossow

Seiffert

2015

Supramolecular Polymer Networks and Gels

View full text Add to dashboard Cite

Section: Synthetic Polymersmentioning

confidence: 99%

Supramolecular Polymer Networks: Preparation, Properties, and Potential

Rossow

Seiffert

2015

Supramolecular Polymer Networks and Gels

View full text Add to dashboard Cite

“…27 These additives are of interest because they contain larger PEG chains and hence could lead to more hydrophilic surfaces and thus less cell adhesion. Furthermore, both compounds contain an extra aliphatic dodecyl spacer between the UPy and the PEG, which can shield the urea groups from interactions with water of the PEG and can lead to enhanced anchoring in the PCLdiUPy base material.…”

Section: Introductionmentioning

confidence: 99%

Cell and Protein Fouling Properties of Polymeric Mixtures Containing Supramolecular Poly(ethylene glycol) Additives

2017

Self Cite

View full text Add to dashboard Cite

Fouling properties of new biomaterials are important for the performance of a material in a biological environment. Here, a set of three supramolecular polymeric additives consisting of ureidopyrimidinone (UPy)-functionalized poly(ethylene glycol) (UPyPEG) were formulated with UPy-modified polycaprolactone into thin supramolecular material films. The antifouling properties of these material films were determined by investigation of the relation of cell adhesion and protein adsorption on these materials films. The presence of the UPyPEG additives at the surface of the films was evident by an increased hydrophilicity. Adhesion of human epithelial and endothelial cells was strongly reduced for two of the UPyPEG-containing films. Analysis of adsorption of the first three proteins from the Vroman series, albumin, γ-globulin, and fibrinogen, using quartz crystal microbalance with dissipation in combination with viscoelastic modeling, revealed that the surfaces containing the UPyPEG additives had a limited effect on adsorption of these proteins. Despite a limited reduction of protein adsorption, UPyPEG-containing mixtures were non-cell-adhesive, which shows that non-cell-adhesive properties of supramolecular polymer surfaces are not always directly correlated to protein adsorption.

show abstract

“…Finally, it is important to consider the transition from the solution to the solid state and to compare covalent polymers with supramolecular assemblies. Based on the rich rheological behavior of supramolecular polymers 71 and supramolecular assemblies 72 in the non-dilute regime missing studies over wide concentration range are considered necessary.…”

Section: Concluding Remarks -Perspectivesmentioning

confidence: 99%

Shape Persistence in Polymers and Supramolecular Assemblies

Wunderlich

Müllen

Fytas

2017

Conjugated Polymers and Oligomers

View full text Add to dashboard Cite

A thorough insight into the shape of polymers and supramolecular assemblies is of crucial importance for the flow behavior, the packing in the solid as well as the structure and dynamics in non-dilute solutions. In this chapter, we present the main experimental techniques that can reliably address persistence and compare different polymers with reported persistence lengths ranging from few nanometers to few hundreds nanometers. Specifically, we discuss not only the so-called rigid-rod polymers such as polyphenylenes, but also dendronized and helical polymers. These chaintype macromolecules are generally considered as rigid or semi-rigid compared with conventional homopolymers such as polyolefins. Next it is meaningful to compare these covalently bonded polymers with supramolecular assemblies consisting of amphiphilic polymers such as poly(ethylene glycol) functionalized benzene derivatives and poly(ethylene oxide-b-butadiene). Supramolecular assemblies can assume larger rigidity than covalently bonded polymers. Although we can classify different types of polymers and supramolecular assemblies and determine their persistence lengths, so far, there is no clear structure-rigidity relationship. Hence, a prediction of the persistence lengths solely based on the molecular structures remains uncertain.

show abstract

Mesoscale Modulation of Supramolecular Ureidopyrimidinone-Based Poly(ethylene glycol) Transient Networks in Water

Cited by 87 publications

References 29 publications

Supramolecular Polymer Networks: Preparation, Properties, and Potential

Supramolecular Polymer Networks: Preparation, Properties, and Potential

Cell and Protein Fouling Properties of Polymeric Mixtures Containing Supramolecular Poly(ethylene glycol) Additives

Shape Persistence in Polymers and Supramolecular Assemblies

Contact Info

Product

Resources

About