Mesoporous silicas templated by heterocyclic amino acid derivatives: Biomimetic synthesis and drug release application

Li, Heran; Ke, Jia; Li, Haiting; Chen, Wei; Wu, Xue‐Qian; Li, Jing; Yang, Yang; Xu, Lu; Liu, Hongzhuo; Li, Sanming; Yang, Mingshi; Wei, Minjie

doi:10.1016/j.msec.2018.07.081

Cited by 9 publications

(11 citation statements)

References 42 publications

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“…Previous studies of the Tuguiwula UHT meta-pelitic granulite have demonstrated that although some zircon grains show blurry core-rim textures, different zones cannot be analysed easily, owing to the small grain size (50-100 µm). Therefore, most previous analyses have focused on the homogeneous grey crystals, defining a single population with a weighted mean age of 1919 AE 10 Ma using SHRIMP II (Santosh et al 2007, 2012, Li and Wei 2018. In this work, using our high spatial resolution dating technique, different internal zones in zircon grains from sample TPS-2 were measured separately, and although cores may appear slightly older than rims, similar ages were yielded within uncertainty (Figure 9c).…”

Section: Case 2: Sample Of Palaeoproterozoic Uht Granulitementioning

confidence: 95%

An Improved In Situ Zircon U‐Pb Dating Method at High Spatial Resolution (≤ 10 μm Spot) by LA‐MC‐ICP‐MS and its Application

Lin

Zhang

et al. 2021

Geostandard Geoanalytic Res

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In situ small‐spot U‐Pb geochronology is essential for measuring zircon crystals containing micrometre‐scale heterogeneities, abundant inclusions, inevitable cracks and narrow growth zones, all of which are especially common in metamorphic zircons. We present a high spatial resolution (≤ 10 μm diameter) laser ablation‐multi‐collector‐inductively coupled plasma‐mass spectrometry (LA‐MC‐ICP‐MS) U‐Pb dating method using a Nu Plasma II mass spectrometer coupled with a GeoLas HD laser ablation system, which is capable of analysing zircon crystals with a wide range of U contents through two analytical modes (mixed‐mode for 10 μm ablation and IC‐mode for 5 μm ablation). We examined Pb/U down‐hole fractionation (DHF) as a function of different laser settings under small‐spot ablation, and how it controls the accuracy and precision of U‐Pb ages of zircon reference materials. After DHF correction using Iolite software (version 3.71), five measurement sessions (with different laser fluence and/or laser pulse settings) for the two analytical modes yielded accurate and precise U‐Pb ages for four zircon reference materials (Plešovice, 91500, GJ‐1 and Temora‐2). Further determinations of U‐Pb ages of three metamorphic zircon samples (~ 14 to 2000 Ma) from the Himalaya, North China Craton and North Qaidam were conducted, the results of which confirm the effectiveness and feasibility of this small‐spot ablation method for natural zircons with multiple growth zones.

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Section: Case 2: Sample Of Palaeoproterozoic Uht Granulitementioning

confidence: 95%

An Improved In Situ Zircon U‐Pb Dating Method at High Spatial Resolution (≤ 10 μm Spot) by LA‐MC‐ICP‐MS and its Application

Lin

Zhang

et al. 2021

Geostandard Geoanalytic Res

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“…The computational formula's mathematical models were according to the previous papers. 32,42,43 The equation that best fitted with the release data was evaluated based on the correlation coefficient (R 2 ).…”

Section: In Vitro Release Studymentioning

confidence: 99%

“…It is worth mentioning that the exponent n in the Ritger-Peppas model confirmed the release mechanism: if n < 0.5, the release mechanism followed the Fickian diffusion model. 32,42 Herein the release exponent n for IBU/ B-BMSF@PEI was respectively valued at 0.179 and 0.229, and was relative to the Fickian diffusion transport mechanism. This finding was in good agreement with the previous studies that drug dissolution out from MSNs was a mainly diffusion-controlled process.…”

Section: Kinetics Of Releasementioning

confidence: 99%

“…A great number of amine-containing biomacromolecules are easily available and in turn facilitate the versatility of silica structure carriers, thus resulting in multiple morphogenesis of biomimetic synthesized silicas including nanospheres, nanoflakes, nanoribbons, nanosheets, twisted nanorods, helical nanofibers, curved nanofilms and large aggregates. [28][29][30][31][32][33][34] Poly(ethyleneimine)s (PEIs) are weak polyelectrolytes which are extensively used as flocculating agents, adhesives and thickeners, especially in the paper industry and biomedical applications. 27,35 PEIs are able to assemble to form superhydrophobic multilayered surfaces and are used to formulate hybrid inorganic materials.…”

Section: Introductionmentioning

confidence: 99%

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<p>Biomimetic Synthesis and Evaluation of Interconnected Bimodal Mesostructured MSF@Poly(Ethyleneimine)s for Improved Drug Loading and Oral Adsorption of the Poorly Water-Soluble Drug, Ibuprofen</p>

Wei¹,

Wang²,

Guo³

et al. 2020

IJN

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The aim of this study was to improve the oral bioavailability and antiinflammatory activity of the poorly soluble drug ibuprofen (IBU) by employing a new kind of poly(ethyleneimine)s (PEIs)-based mesocellular siliceous foam (MSF) called B-BMSF@PEI as drug carrier. Methods: B-BMSF@PEI was biomimetically synthesized by using PEIs as templates, catalysts and scaffolds under ambient conditions, and the structural characteristics, including size, morphology, mesoscopic structure and pore properties, were estimated by TEM, SEM, FTIR and N 2 desorption/adsorption measurement. Then, IBU was incorporated into B-BMSF@PEI at the drug:carrier weight ratio of 1:1. The structural features of IBU before and after drug loading were systemically characterized. IBU and B-BMSF@PEI were then subject to in vitro drug release study and wettability analysis. Finally, in vivo pharmacokinetics and anti-inflammatory pharmacodynamics studies were carried out to evaluate the efficacy of B-BMSF@PEI on improving the oral adsorption of IBU. Results: The results demonstrated that B-BMSF@PEI was a meso-meso porous silica material with foam appearance. It consisted of uniform spherical cells (40 nm) with interconnected pore networks. IBU can be successfully loaded into B-BMSF@PEI with high efficiency (as high as 39.53%), and crystal IBU was effectively converted to an amorphous state during this process. Benefiting from the great architectures of B-BMSF@PEI, IBU/ B-BMSF@PEI performed good wetting property and significantly improved the dissolution rate in both simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Notably, IBU exhibited very satisfactory relative bioavailability (681.4%) and anti-inflammatory effects (the inhibition rates were between the ranges of 113.5% to 1504.3%). Conclusion: B-BMSF@PEI with bimodal mesoporous system and interconnected nanopores was obtained owing to the dynamic self-assembly functions of PEIs. It had superiority in drug loading and could improve the oral adsorption of ibuprofen to a satisfactory level.

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“…Li et al. also revealed that MSNs with disordered nanopores showed a quicker release behavior as a result of a shorter diffusion distance (Li et al., 2018 ). It seems that pore morphology is thought to greatly affect the drug loading and release behavior (Wang et al., 2015 , Li et al., 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Facile synthesis of PEI-based crystalline templated mesoporous silica with molecular chirality for improved oral delivery of the poorly water-soluble drug

et al. 2021

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The aim of this study was to build up a novel chiral mesoporous silica called PEIs@TA-CMS through a facile biomimetic strategy and to explore its potential to serve as a drug carrier for improving the delivery efficiency of poorly water-soluble drug. PEIs@TA-CMS was synthesized by using a chiral crystalline complex associated of tartaric acid and polyethyleneimine (PEIs) as templates, scaffolds and catalysts. The structural features including morphology, size, pore structure and texture properties were systematacially studied. The results showed that PEIs@TA-CMS was monodispersed spherical nanoparticles in a uniformed diameter of 120–130 nm with well-developed pore structure (S BET : 1009.94 m 2 /g, pore size <2.21 nm). Then PEIs@TA-CMS was employed as nimodipine (NMP) carrier and compared with the drug carry ability of MCM41. After drug loading, NMP was effectively transformed from the crystalline state to an amorphous state due to the space confinement in mesopores. As expected, PEIs@TA-CMS had superiority in both drug loading and drug release compared to MCM41. It could incorporate NMP with high efficiency, and the dissolution-promoting effect of PEIs@TA-CMS was more obvious because of the unique interconnected curved pore channels. Meanwhile, PEIs@TA-CMS could significantly improve the oral adsorption of NMP to a satisfactory level, which showed approximately 3.26-fold higher in bioavailability, and could effectively prolong the survival time of mice on cerebral anoxia from 10.98 to 17.33 min.

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Mesoporous silicas templated by heterocyclic amino acid derivatives: Biomimetic synthesis and drug release application

Cited by 9 publications

References 42 publications

An Improved In Situ Zircon U‐Pb Dating Method at High Spatial Resolution (≤ 10 μm Spot) by LA‐MC‐ICP‐MS and its Application

An Improved In Situ Zircon U‐Pb Dating Method at High Spatial Resolution (≤ 10 μm Spot) by LA‐MC‐ICP‐MS and its Application

<p>Biomimetic Synthesis and Evaluation of Interconnected Bimodal Mesostructured MSF@Poly(Ethyleneimine)s for Improved Drug Loading and Oral Adsorption of the Poorly Water-Soluble Drug, Ibuprofen</p>

Facile synthesis of PEI-based crystalline templated mesoporous silica with molecular chirality for improved oral delivery of the poorly water-soluble drug

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