Mesoporous silica with fibrous morphology: a multifunctional core–shell platform for biomedical applications

Atabaev, Timur Sh.; Lee, Jong Ho; Lee, Jun-Jae; Han, Dong‐Wook; Hwang, Yoon Hwae; Kim, Hyung Kook; Hong, Nguyen Hoa

doi:10.1088/0957-4484/24/34/345603

Cited by 44 publications

(21 citation statements)

References 19 publications

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“…Hong and co‐workers prepared multifunctional CDDSs by using magnetic DFNS and fluorescent labeling for drug delivery as well as real‐time imaging . Magnetic and fluorescent DFNS was prepared with iron‐oxide seeds and fluorescein dye by using the standard protocol for the synthesis of DFNS.…”

Section: Biomedical Applications Using Dfnsmentioning

confidence: 99%

Dendritic Fibrous Nanosilica for Catalysis, Energy Harvesting, Carbon Dioxide Mitigation, Drug Delivery, and Sensing

2017

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Morphology‐controlled nanomaterials such as silica play a crucial role in the development of technologies for addressing challenges in the fields of energy, environment, and health. After the discovery of Stöber silica, followed by that of mesoporous silica materials, such as MCM‐41 and SBA‐15, a significant surge in the design and synthesis of nanosilica with various sizes, shapes, morphologies, and textural properties has been observed in recent years. One notable invention is dendritic fibrous nanosilica, also known as KCC‐1. This material possesses a unique fibrous morphology, unlike the tubular porous structure of various conventional silica materials. It has a high surface area with improved accessibility to the internal surface, tunable pore size and pore volume, controllable particle size, and, importantly, improved stability. Since its discovery, a large number of studies have been reported concerning its use in applications such as catalysis, solar‐energy harvesting, energy storage, self‐cleaning antireflective coatings, surface plasmon resonance‐based ultrasensitive sensors, CO2 capture, and biomedical applications. These reports indicate that dendritic fibrous nanosilica has excellent potential as an alternative to popular silica materials such as MCM‐41, SBA‐15, Stöber silica, and mesoporous silica nanoparticles. This Review provides a critical survey of the dendritic fibrous nanosilica family of materials, and the discussion includes the synthesis and formation mechanism, applications in catalysis and photocatalysis, applications in energy harvesting and storage, applications in magnetic and composite materials, applications in CO2 mitigation, biomedical applications, and analytical applications.

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Section: Biomedical Applications Using Dfnsmentioning

confidence: 99%

Dendritic Fibrous Nanosilica for Catalysis, Energy Harvesting, Carbon Dioxide Mitigation, Drug Delivery, and Sensing

2017

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“…Moreover, the addition of ethyl ether to emulsions stabilized with surfactants has also been utilized to obtain MSNs with large pore sizes. 306,309,314,316,319,321,332,334 However, the colloidal dispersities of these MSNs were not investigated. Furthermore, the diameters of the MSNs were limited to greater than 100 nm.…”

Section: Soft Template;mentioning

confidence: 99%

Colloidal Mesoporous Silica Nanoparticles

Yamamoto

Kuroda

2016

Bulletin of the Chemical Society of Japan

197

100

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IMMA. His current research interests include mesostructured materials, and several fields of inorganic materials chemistry. Some examples are intercalation chemistry, silicate chemistry, inorganic polymers, sol-gel chemistry, inorganic-organic hybrids, and self-organized materials. AbstractMesoporous silica nanoparticles (MSNs) with colloidal stability have attracted increasing interest because of their important properties, such as high transparency and cell uptake. Colloidal MSNs are comprehensively reviewed from the viewpoints of their preparation, characterization, and applications which include biomedical, catalytic, and optical materials. The following two points have been emphasized. The first point is that this review covers the widest range of introduction and discussion of the preparation and applications of both colloidal and noncolloidal MSNs. The second point is that this account contains a discussion from the viewpoints of both inorganic and colloid chemistries. After the introduction of the historical background of preparation of MSNs, preparative methods of colloidal MSNs and the major factors for the preparation of nanosized and colloidal MSNs are discussed. The methods to control the size, composition, morphology, and pore size of MSNs are also presented. Appropriate methods to obtain MSNs with high colloidal dispersibility are also discussed. Applications of colloidal MSNs are introduced with an emphasis on the colloidal stability. Issues to be addressed for further developments of colloidal MSNs are finally described.

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“…Thus, the successful RNA interference therapy strongly relies on the development of efficient gene delivery systems. magnetization (<20 emu g −1 ) due to a low fraction of magnetic component loading, [18,[24][25][26] or the porosity is significantly compromised by high magnetic loading inside the pore structure. [27] Furthermore, although various types of stimuliresponsive switches have been designed on traditional MSNs for controlled release of small molecule drugs, similar function is seldom realized on large-pore MSNs for release of siRNA and the realization usually needs complex multistep preparation processes.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Core–Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery

Xiong

Tang³

et al. 2016

Small

102

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A novel type of magnetic core-shell silica nanoparticles is developed for small interfering RNA (siRNA) delivery. These nanoparticles are fabricated by coating super-paramagnetic magnetite nanocrystal clusters with radial large-pore mesoporous silica. The amine functionalized nanoparticles have small particle sizes around 150 nm, large radial mesopores of 12 nm, large surface area of 411 m(2) g(-1) , high pore volume of 1.13 cm(3) g(-1) and magnetization of 25 emu g(-1) . Thus, these nanoparticles possess both high loading capacity of siRNA (2 wt%) and strong magnetic response under an external magnetic field. An acid-liable coating composed of tannic acid can further protect the siRNA loaded in these nanoparticles. The coating also increases the dispersion stability of the siRNA-loaded carrier and can serve as a pH-responsive releasing switch. Using the magnetic silica nanoparticles with tannic acid coating as carriers, functional siRNA has been successfully delivered into the cytoplasm of human osteosarcoma cancer cells in vitro. The delivery is significantly enhanced with the aid of the external magnetic field.

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Mesoporous silica with fibrous morphology: a multifunctional core–shell platform for biomedical applications

Cited by 44 publications

References 19 publications

Dendritic Fibrous Nanosilica for Catalysis, Energy Harvesting, Carbon Dioxide Mitigation, Drug Delivery, and Sensing

Dendritic Fibrous Nanosilica for Catalysis, Energy Harvesting, Carbon Dioxide Mitigation, Drug Delivery, and Sensing

Colloidal Mesoporous Silica Nanoparticles

Magnetic Core–Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery

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