Mesoporous silica SBA-16 nanoparticles: Synthesis, physicochemical characterization, release profile, and in vitro cytocompatibility studies

Andrade, Gracielle Ferreira; Soares, Daniel Crístian Ferreira; Santos, Raquel Gouvêa dos; Sousa, Edésia Martins Barros de

doi:10.1016/j.micromeso.2012.09.034

Cited by 62 publications

(26 citation statements)

References 43 publications

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“…[49,50]. Furthermore, the broad band at 3400 cm −1 was observed which is assigned to O H bond stretching of the surface silanol groups and to the remaining adsorbed water.…”

Section: Characterization Of Mesoporous Adsorbentsmentioning

confidence: 94%

Aminopropyl-modified mesoporous molecular sieves as efficient adsorbents for removal of auxins

Moritz

Geszke-Moritz

2015

Applied Surface Science

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“…[49,50]. Furthermore, the broad band at 3400 cm −1 was observed which is assigned to O H bond stretching of the surface silanol groups and to the remaining adsorbed water.…”

Section: Characterization Of Mesoporous Adsorbentsmentioning

confidence: 94%

Aminopropyl-modified mesoporous molecular sieves as efficient adsorbents for removal of auxins

Moritz

Geszke-Moritz

2015

Applied Surface Science

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“…No chromosomal alterations were observed for cells treated with 200 mg/mL of silica. 164 Lu et al have reported the cell viability of mesoporous magnesium calcium silicate on MC 3T3-E1 cells. 165 Table.1 gives an overview of the cytocompatibility of various natural polymer/inorganic materials based hybrid scaffolds.…”

Section: Biocompatibility and Concentration Dependent Toxicitymentioning

confidence: 99%

Natural Polymer/Inorganic Material Based Hybrid Scaffolds for Skin Wound Healing

et al. 2015

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Dermal tissue engineering focuses on the restoration of diseased and damaged tissues by using a combination of cells, biomaterials, and bioactive molecules. Inorganic substances like zeolites, clay, mesoporous silica, metals, and metal oxides are advanced materials used in wound healing research. They can improve the structural stability and bioactivity of bio polymeric scaffolds. Zeolites, clays, and mesoporous silica act as suitable carriers for drug delivery and when incorporated within scaffolds, serve as ideal matrices for promoting skin regeneration. This review focuses on various natural polymers/inorganic materials based composite scaffolds used for skin tissue engineering, highlighting their synthesis routes and mode of action by which wound healing is enhanced. Among the different inorganic materials used, the role of zeolites incorporated biocomposites for promoting blood coagulation, antibacterial effect; oxygen delivery to cells and wound healing are discussed in detail. The article thus includes recent attempts to explore the hidden potential of inorganic materials in dermal tissue engineering.

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“…A second possible explanation for this slow release may have been the pH value. Finally, it is possible that the FFA could have been easily hydrolyzed in the buffer used for the assay, which would have compromised the detection of the intact molecule at 288 nm [40,41]. However, the antioxidant role of FFA may be carried out when still interacting or trapped inside the MCM-41, within the 48 h chosen as the timepoint for the in vitro biocompatibility assay, as shown below.…”

Section: Resultsmentioning

confidence: 99%

Response of Fibroblasts MRC-5 to Flufenamic Acid-Grafted MCM-41 Nanoparticles

et al. 2018

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Recently, flufenamic acid (FFA) was discovered among fenamates as a free radical scavenger and gap junction blocker; however, its effects have only been studied in cancer cells. Normal cells in the surroundings of a tumor also respond to radiation, although they are not hit by it directly. This phenomenon is known as the bystander effect, where response molecules pass from tumor cells to normal ones, through communication channels called gap junctions. The use of the enhanced permeability and retention effect, through which drug-loaded nanoparticles smaller than 200 nm may accumulate around a tumor, can prevent the local side effect upon controlled release of the drug. The present work, aimed at functionalizing MCM-41 (Mobil Composition of Matter No. 41) silica nanoparticles with FFA and determining its biocompatibility with human fibroblasts MRC-5 (Medical Research Council cell strain 5). MCM-41, was synthesized and characterized structurally and chemically, with multiple techniques. The biocompatibility assay was performed by Live/Dead technique, with calcein and propidium–iodide. MRC-5 cells were treated with FFA-grafted MCM-41 for 48 h, and 98% of cells remained viable, without signs of necrosis or morphological changes. The results show the feasibility of MCM-41 functionalization with FFA, and its potential protection of normal cells, in comparison to the role of FFA in cancerous ones.

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Mesoporous silica SBA-16 nanoparticles: Synthesis, physicochemical characterization, release profile, and in vitro cytocompatibility studies

Cited by 62 publications

References 43 publications

Aminopropyl-modified mesoporous molecular sieves as efficient adsorbents for removal of auxins

Aminopropyl-modified mesoporous molecular sieves as efficient adsorbents for removal of auxins

Natural Polymer/Inorganic Material Based Hybrid Scaffolds for Skin Wound Healing

Response of Fibroblasts MRC-5 to Flufenamic Acid-Grafted MCM-41 Nanoparticles

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