Mesoporous silica pellets – A promising oral drug delivery system?

Szewczyk, Adrian; Prokopowicz, Magdalena

doi:10.1016/j.jddst.2019.101491

Cited by 4 publications

(7 citation statements)

References 60 publications

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“…Moreover, the DOX fraction present on the external silica surface dissolved immediately after immersion in the release medium. A similar release rate of DOX from mesoporous silicas has been previously observed in ours [ 22 , 36 ] and other researchers’ works [ 38 , 39 ].…”

Section: Resultssupporting

confidence: 91%

“…The Fourier transform infrared spectroscopy (FTIR) results ( Figure 2 a) also confirmed the presence of DOX in the MCM-DOX sample and agreed with our previous studies in which DOX was successfully adsorbed onto SBA-15 mesoporous silica [ 36 ]. The spectrum of the MCM-DOX showed bands characteristic for both MCM-41 and DOX molecules.…”

Section: Resultssupporting

confidence: 89%

“…The spectrum of the MCM-DOX showed bands characteristic for both MCM-41 and DOX molecules. The bands at 1631, 1232, 1087, 965, 801, and 462 cm −1 derived from MCM-41 (H-O-H deformation vibrations of physisorbed water, external and internal Si-O-Si asymmetric stretching, Si-OH stretching, Si-O-Si symmetric stretching, and O-Si-O deformation vibrations, respectively), whereas the bands at 1580, 1519, and 1458 cm −1 were characteristic for DOX molecules (C=O stretching; N-H bending, and C-H bending vibrations, respectively) [ 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…Due to the rapid release of DOX from MCM-DOX samples (>60% in 5 min), the kinetics parameters for these samples are not presented. In our previous studies [ 22 , 36 ], the DOX release from drug-loaded mesoporous silica powders was characterized by simple Fickian diffusion ( n ≤ 0.43). Herein, when the DOX-loaded MCM-41 powders were transformed into the pellets, the diffusion seemed to be still a predominant mechanism of drug release.…”

Section: Resultsmentioning

confidence: 99%

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Mesoporous Silica-Bioglass Composite Pellets as Bone Drug Delivery System with Mineralization Potential

Szewczyk

Skwira

Konopacka

et al. 2021

IJMS

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For decades, local bone drug delivery systems have been investigated in terms of their application in regenerative medicine. Among them, inorganic polymers based on amorphous silica have been widely explored. In this work, we combined two types of amorphous silica: bioglass and doxycycline-loaded mesoporous silica MCM-41 into the form of spherical granules (pellets) as a bifunctional bone drug delivery system. Both types of silica were obtained in a sol-gel method. The drug adsorption onto the MCM-41 was performed via adsorption from concentrated doxycycline hydrochloride solution. Pellets were obtained on a laboratory scale using the wet granulation-extrusion-spheronization method and investigated in terms of physical properties, drug release, antimicrobial activity against Staphylococcus aureus, mineralization properties in simulated body fluid, and cytotoxicity towards human osteoblasts. The obtained pellets were characterized by satisfactory mechanical properties which eliminated the risk of pellets cracking during further investigations. The biphasic drug release from pellets was observed: burst stage (44% of adsorbed drug released within the first day) followed by prolonged release with zero-order kinetics (estimated time of complete drug release was 19 days) with maintained antimicrobial activity. The progressive biomimetic apatite formation on the surface of the pellets was observed. No cytotoxic effect of pellets towards human osteoblasts was noticed.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Mesoporous Silica-Bioglass Composite Pellets as Bone Drug Delivery System with Mineralization Potential

Szewczyk

Skwira

Konopacka

et al. 2021

IJMS

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“…Silica is a well-known biocompatible material and has been used to enhance biocompatibility by altering the surface properties of implanted materials when exposed to the human body. Due to their high chemical loading capabilities, many attempts have been performed to release the therapeutic moieties in a controlled manner for prolonged drug delivery system (DDS) and mineralization potential [ 10 ]. Even though the silica-based particles have various advantages, they are hard to use as therapeutic molecules due to their high hydrophobicity.…”

Section: Introductionmentioning

confidence: 99%

Real-Time Tracking of Highly Luminescent Mesoporous Silica Particles Modified with Europium β-Diketone Chelates in Living Cells

et al. 2021

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Highly luminescent europium complexes modified mesoporous silica particles (MSP) were synthesized as an imaging probes for both in-vitro diagnostic and in-vivo cellular tracking agents. Europium β-diketone chelates (4,4,4-trifluoro-l-(2-thienyl)-l,3-butanedione) trioctylphosphine europium (III) (Eu(TTA)3(P(Oct)3)3) were incorporated inside the nanocavities that existed in hierarchical MSP (Eu@MSP). The MSP and Eu@MSP on mouse bone marrow-derived macrophages (BMDMs) did not show any toxic effect. The MSP and Eu@MSP in the BMDMs were found at cytoplasm without any degradation and immunogenicity. However, both pro- and anti-inflammatory cytokines of macrophages were significantly increased when lipopolysaccharide and a high concentration (100 μg/mL) of MSP and Eu@MSP were treated simultaneously.

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