Mesoporous Silica Particles Potentiate Antigen-Specific T-Cell Responses

Kupferschmidt, Natalia; Qazi, Khaleda Rahman; Kemi, Cecilia; Vallhov, Helen; Garcia‐Bennett, Alfonso E.; Gabrielsson, Susanne; Scheynius, Annika

doi:10.2217/nnm.13.170

Cited by 32 publications

(21 citation statements)

References 34 publications

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“…First, the core nanoparticles themselves are capable of augmenting immunogenic activity as shown in Figure . Furthermore, recent evidence for this is seen, for example, when MSN and CaP nanoparticles have been tested in conjunction with vaccine and have been shown to enhance and sustain T‐cell responses and in the case of CaP to protect against influenza challenge . The RNA molecule does not have to encode an antigen to potentiate an immune response either, as shown previously, for example, with pIC where its signaling through TLRs and PAMPs are immuno‐stimulatory.…”

Section: Achieving Synergymentioning

confidence: 82%

“…Therefore, the above results should be interpreted with some caution and may be cell type and route of administration dependent. These need to be balanced by modulation of CD, increases in serum IgG, IgM, chemokines, MHC‐I, and MHC‐II reported for MSN and other nanoparticles which could otherwise contribute a desirable immunological component to an RNA vaccine or dsRNA as discussed next …”

Section: Nanoparticle Immunologymentioning

confidence: 99%

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Toward RNA nanoparticle vaccines: synergizing RNA and inorganic nanoparticles to achieve immunopotentiation

Delong

Curtis

2016

WIREs Nanomed Nanobiotechnol

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Traditionally, vaccines have been composed of live attenuated or killed micro-organisms. Alternatively, individual protein subunits or other molecular components of the micro-organism can serve as the antigen and trigger an antibody response by the immune system. The immune system is a coordinated molecular and cellular response that works in concert to check the spread of infection. In the past decade, there has been much progress on DNA vaccines. DNA vaccination includes using the coding segments of a viral or bacterial genome to generate an immune response. However, the potential advantage of combining an RNA molecule with inorganic nanoparticle delivery should be considered, with the goal to achieve immuno-synergy between the two and to overcome some of the current limitations of DNA vaccines and traditional vaccines.

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Section: Achieving Synergymentioning

confidence: 82%

Section: Nanoparticle Immunologymentioning

confidence: 99%

Toward RNA nanoparticle vaccines: synergizing RNA and inorganic nanoparticles to achieve immunopotentiation

Delong

Curtis

2016

WIREs Nanomed Nanobiotechnol

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“…studies have indicated that dendritic cells (DCs) and macrophages, which are especially abundant in the mucosae and the skin, not only undergo oxidative stress, necrosis, and apoptosis but also overexpress T lymphocyte-stimulating proteins, such as major histocompatibility complex class II (MHC-II), CD80, and CD86, and secrete several proinflammatory cytokines and chemokines when they are treated with a variety of NPs (mesoporous silica NPs [SiO 2 NPs], TiO 2 NPs, and silica-coated iron dioxide and TiO 2 NPs) (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Consistent with that finding, in mouse models, various modified silica NPs increased the efficacy with which DCs induced the differentiation of gamma interferon (IFN-␥)-producing CD8 ϩ T lymphocytes (Tc1), a phenotype linked with tissue inflammatory diseases, such as delayed-type hypersensitivity (DTH), characterized by macrophage and polymorphonuclear leukocyte (PMN) infiltration (18).…”

mentioning

confidence: 99%

Combined Action of Human Commensal Bacteria and Amorphous Silica Nanoparticles on the Viability and Immune Responses of Dendritic Cells

Malachin

Lubian

Mancin

et al. 2017

Clin Vaccine Immunol

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Dendritic cells (DCs) regulate the host-microbe balance in the gut and skin, tissues likely exposed to nanoparticles (NPs) present in drugs, food, and cosmetics. We analyzed the viability and the activation of DCs incubated with extracellular media (EMs) obtained from cultures of commensal bacteria (Escherichia coli, Staphylococcus epidermidis) or pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus) in the presence of amorphous silica nanoparticles (SiO 2 NPs). EMs and NPs synergistically increased the levels of cytotoxicity and cytokine production, with different nanoparticle dose-response characteristics being found, depending on the bacterial species. E. coli and S. epidermidis EMs plus NPs at nontoxic doses stimulated the secretion of interleukin-1␤ (IL-1␤), IL-12, IL-10, and IL-6, while E. coli and S. epidermidis EMs plus NPs at toxic doses stimulated the secretion of gamma interferon (IFN-␥), tumor necrosis factor alpha (TNF-␣), IL-4, and IL-5. On the contrary, S. aureus and P. aeruginosa EMs induced cytokines only when they were combined with NPs at toxic concentrations. The induction of maturation markers (CD86, CD80, CD83, intercellular adhesion molecule 1, and major histocompatibility complex class II) by commensal bacteria but not by pathogenic ones was improved in the presence of noncytotoxic SiO 2 NP doses. DCs consistently supported the proliferation and differentiation of CD4 ϩ and CD8 ϩ T cells secreting IFN-␥ and IL-17A. The synergistic induction of CD86 was due to nonprotein molecules present in the EMs from all bacteria tested. At variance with this finding, the synergistic induction of IL-1␤ was prevalently mediated by proteins in the case of E. coli EMs and by nonproteins in the case of S. epidermidis EMs. A bacterial costimulus did not act on DCs after adsorption on SiO 2 NPs but rather acted as an independent agonist. The inflammatory and immune actions of DCs stimulated by commensal bacterial agonists might be altered by the simultaneous exposure to engineered or environmental NPs.

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“…Various studies have reported the successful evaluation of such multifunctional MPSNPs as antigen carrier as well as adjuvants for the delivery of vaccines (Heidegger et al, ). Thus, MPSNPs has exhibited intrinsic adjuvant activity under different conditions, therefore, enhancing immune responses of antigen‐specific T‐cell (Kupferschmidt et al, ). It is remarkable that MPSNPs have been reported to promote MHC Class I‐limited demonstration of antigens by a dendritic cell of human, which is also known as cross‐presentation (Jimenez‐Perianez et al, ).…”

Section: Role Of Mpsnps the Simulation Of The Immune Systemmentioning

confidence: 99%

Targeted and stimuli–responsive mesoporous silica nanoparticles for drug delivery and theranostic use

Aquib

Farooq

Banerjee

et al. 2019

J Biomedical Materials Res

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For cancer therapy, the usefulness of mesoporous silica nanoparticles (MPSNPs) has been widely discussed, likely due to its inorganic nature and excellent structural features. The MPSNPs‐based chemotherapeutics have been promisingly delivered to their target sites that help to minimize side effects and improve therapeutic effectiveness. A wide array of studies have been conducted to functionalize drug‐loaded MPSNPs using targeting ligands and stimuli‐sensitive substances. In addition, anticancer drugs have been precisely delivered to their target sites using MPSNPs, which respond to multi‐stimuli. Furthermore, MPSNPs have been extensively tested for their safety and compatibility. The toxicity level of MPSNPs is substantially lower as compared to that of colloidal silica; however, in oxidative stress, they exhibit cytotoxic features. The biocompatibility of MPSNPs can be improved by modifying their surfaces. This article describes the production procedures, functionalization, and applications of biocompatible MPSNPs in drug delivery.

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Mesoporous Silica Particles Potentiate Antigen-Specific T-Cell Responses

Abstract: Pore size is an important parameter for reduction of body weight and body fat composition by mesoporous silica, demonstrating promising signs for the treatment of obesity.

Cited by 32 publications

References 34 publications

Toward RNA nanoparticle vaccines: synergizing RNA and inorganic nanoparticles to achieve immunopotentiation

Toward RNA nanoparticle vaccines: synergizing RNA and inorganic nanoparticles to achieve immunopotentiation

Combined Action of Human Commensal Bacteria and Amorphous Silica Nanoparticles on the Viability and Immune Responses of Dendritic Cells

Targeted and stimuli–responsive mesoporous silica nanoparticles for drug delivery and theranostic use

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