Mesoporous silica nanoparticles with lactose-mediated targeting effect to deliver platinum(iv) prodrug for liver cancer therapy

Abstract

A mesoporous silica nanoparticle system with a lactose-mediated targeting effect was demonstrated to deliver a platinum(iv) prodrug for liver cancer therapy.

Enhancing surface immobilization of bioactive moleculesviaa silica nanoparticle based coating

“…Silica nanoparticles are commonly employed for drug delivery 12 and have been well characterized as biocompatible. 13,14 In addition, the surface properties can be easily modified via direct functionalization 15 or by incorporating different monomers into the reaction solution, 15,16 producing nanoparticles with active thiol 16,17 or amine 15 groups. Together, these properties make silica nanoparticles attractive candidates for surface modification when biocompatibility is a concern.…”

Metal Species–Encapsulated Mesoporous Silica Nanoparticles: Current Advancements and Latest Breakthroughs

“…In the past two decades, tremendous progress has been evidenced by advancements in fabricating different inorganic nanosystems with intrinsic functionalities for diverse applications, due to their unique advantages such as ease of synthesis and scalability, cost‐effectiveness, and size‐ and shape‐dependent physicochemical properties . Among the various types of inorganic nanomaterials available, mesoporous silica nanoparticles (MSNs), have garnered vast interest from researchers due to their attractive physicochemical features such as tunable morphology, extensive surface area (≈1500 m 2 g −1 ) and pore volume, adjustable and uniformly sized mesopores (2–5 nm), tunable sizes (50–150 nm), shapes (hexagonal, wormhole‐like, cubic, and lamellar) and morphologies (spheres, helical fibers, tubules, gyroids, crystals, and numerous other hierarchical complex architectures), ease of surface functionalization (both interior as well as exterior), unique topology, colloidal and thermal stabilities, and high dispersity . The exceptional topology of surfactant‐templated MSNs makes them unique with desirable properties that can be obtained by controlling the preparation conditions, such as the reaction temperature, pH value, stirring speed, and type of silica source, as well as surfactant, among others 4j,m,n,5.…”

“…Among the various types of inorganic nanomaterials available, mesoporous silica nanoparticles (MSNs), have garnered vast interest from researchers due to their attractive physicochemical features such as tunable morphology, extensive surface area (≈1500 m 2 g −1 ) and pore volume, adjustable and uniformly sized mesopores (2–5 nm), tunable sizes (50–150 nm), shapes (hexagonal, wormhole‐like, cubic, and lamellar) and morphologies (spheres, helical fibers, tubules, gyroids, crystals, and numerous other hierarchical complex architectures), ease of surface functionalization (both interior as well as exterior), unique topology, colloidal and thermal stabilities, and high dispersity . The exceptional topology of surfactant‐templated MSNs makes them unique with desirable properties that can be obtained by controlling the preparation conditions, such as the reaction temperature, pH value, stirring speed, and type of silica source, as well as surfactant, among others 4j,m,n,5. These advantages make the MSNs as versatile materials and ideal choice for catalysis, adsorption, optical devices,4j polymeric fillers, and diverse biomedical applications including bio‐imaging,4r,t,u,9 biocatalysts, biosensing, tissue engineering,4f and drug/gene delivery accounting for targeted and controlled release systems 3d,4i,o‐t,v,12…”

“…The exceptional topology of surfactant‐templated MSNs makes them unique with desirable properties that can be obtained by controlling the preparation conditions, such as the reaction temperature, pH value, stirring speed, and type of silica source, as well as surfactant, among others 4j,m,n,5. These advantages make the MSNs as versatile materials and ideal choice for catalysis, adsorption, optical devices,4j polymeric fillers, and diverse biomedical applications including bio‐imaging,4r,t,u,9 biocatalysts, biosensing, tissue engineering,4f and drug/gene delivery accounting for targeted and controlled release systems 3d,4i,o‐t,v,12…”

“…Despite several reports on MSNs for use in drug delivery and other applications by us and other groups,4f,j,m,o,q,7,15 the scope of this review covers the current advancements and latest breakthroughs in the fabrication of M‐MSNs, emphasizing the pros and cons, the confinement of the metal species in the nanospaces and various factors influencing the encapsulation of metal species in MSNs. In the further sections, we first discuss the importance of metals and their impact on MSNs, highlighting the benefits, challenges, and desirable properties of M‐MSNs.…”