Mesoporous silica nanoparticles: synthesis methods and their therapeutic use-recent advances

Ghaferi, Mohsen; Esfahani, Maedeh Koohi Moftakhari; Raza, Aun; Harthi, Sitah Al; Shahmabadi, Hasan Ebrahimi; Alavi, Seyed Ebrahim

doi:10.1080/1061186x.2020.1812614

Cited by 72 publications

(40 citation statements)

References 340 publications

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“…ABZ has poor water solubility, and as a result, has low bioavailability (56). MSNPs are able to increase the solubility rate of poorly water-soluble drugs (3,22). The present study aimed to increase the e cacy of ABZ against liver cancer cells through loading into MCM-41 NPs.…”

Section: Discussionmentioning

confidence: 99%

“…Also, these carriers, compared to various other polymers utilized to increase drug solubility, have demonstrated higher thermal resistance, higher levels of resistance to pH, and superior stability on storage. The porous structure of MS materials allows them to con ne and stabilize the amorphous state of drug molecules within the pores rather than the crystalline state, resulting in an increase in the solubility rate of the drug molecules (3,22). To synthesize MSNPs, a surfactant micelle is used as a template to direct the polymerization of silica components (scheme 1) (41) .…”

Section: Introductionmentioning

confidence: 99%

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Enhancing the Efficacy of Albendazole for Liver Cancer Treatment Using Mesoporous Silica Nanoparticles: An In Vitro Study

Ghaferi

Zahra

Shahmabadi

et al. 2021

Preprint

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The present study aimed to synthesize albendazole (ABZ)-loaded Mobil Composition of Matter No. 41 (MCM-41) nanoparticles (NPs) to increase the efficacy of the drug against liver cancer. ABZ was loaded into MCM-41 NPs, and after in vitro characterization, such as size, size distribution, zeta potential, morphology, chemical composition, thermal profile, drug release, surface and pore volume, and pore size, their biological effects were evaluated using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) cell migration assays. The results demonstrated that monodispersed and spherical NPs with a size of 220 ± 11.5 and 293 ± 8.7 nm, for MCM-41 NPs and ABZ-loaded MCM-41 NPs, respectively, and drug loading efficiency of 30% were synthesized. ABZ was loaded physically into MCM-41 NPs, leading to a decrease in surface volume, pore size, and pore volume. Also, MCM-41 NPs could increase the cytotoxicity effects of ABZ by 2.9-fold (IC50 = 23 and 7.9 µM for ABZ and ABZ-loaded MCM-41 NPs, respectively). In addition, ABZ-loaded MCM-41 NPs, compared to that of ABZ, caused a significant decrease in cell migration. Overall, the results of the present study suggest evaluating the potency of MCM-41 NPs, as a potent nanoplatform, for ABZ delivery in vivo environment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhancing the Efficacy of Albendazole for Liver Cancer Treatment Using Mesoporous Silica Nanoparticles: An In Vitro Study

Ghaferi

Zahra

Shahmabadi

et al. 2021

Preprint

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“…The versatility and importance of MSNs is explained by the distinctive properties of these kinds of materials: high surface area and pore volume, high thermal stability, easy external surface functionalization, large and tunable pore sizes, and good biocompatibility [ 18 , 19 ]. These last two features are essential in the use of the MSNs as successful vehicles in drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Kidney-Protector Lipidic Cilastatin Derivatives as Structure-Directing Agents for the Synthesis of Mesoporous Silica Nanoparticles for Drug Delivery

Martínez-Erro

Navas

Romaní-Cubells

et al. 2021

IJMS

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Mesoporous silica nanomaterials have emerged as promising vehicles in controlled drug delivery systems due to their ability to selectively transport, protect, and release pharmaceuticals in a controlled and sustained manner. One drawback of these drug delivery systems is their preparation procedure that usually requires several steps including the removal of the structure-directing agent (surfactant) and the later loading of the drug into the porous structure. Herein, we describe the preparation of mesoporous silica nanoparticles, as drug delivery systems from structure-directing agents based on the kidney-protector drug cilastatin in a simple, fast, and one-step process. The concept of drug-structure-directing agent (DSDA) allows the use of lipidic derivatives of cilastatin to direct the successful formation of mesoporous silica nanoparticles (MSNs). The inherent pharmacological activity of the surfactant DSDA cilastatin-based template permits that the MSNs can be directly employed as drug delivery nanocarriers, without the need of extra steps. MSNs thus synthesized have shown good sphericity and remarkable textural properties. The size of the nanoparticles can be adjusted by simply selecting the stirring speed, time, and aging temperature during the synthesis procedure. Moreover, the release experiments performed on these materials afforded a slow and sustained drug release over several days, which illustrates the MSNs potential utility as drug delivery system for the cilastatin cargo kidney protector. While most nanotechnology strategies focused on combating the different illnesses this methodology emphasizes on reducing the kidney toxicity associated to cancer chemotherapy.

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“…multiple myeloma cancer, ovarian cancer, and breast cancer [8]. In recent years, nanotechnology has been widely used to improve a variety of common treatments for cancer [9]. Nanotechnology involves the design, synthesis, and description of materials and devices organized on a nanoscale in at least one dimension, and their characteristics are used to diagnose and treat diseases [8,10].…”

Section: Introductionmentioning

confidence: 99%

Investigation of characterization and cytotoxic effect of PEGylated nanoliposomal containing Melphalan on ovarian cancer: an in vitro study

Mirnezami

Heydarinasab

Akbarzadeh

et al. 2021

Journal of Experimental Nanoscience

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This study aimed to synthesize Melphalan (MEL)-loaded PEGylated nanoliposomes and evaluate their cytotoxic effects on ovarian cancer A2780CP and SKOV3 cells. For this purpose, MEL-loaded PEGylated nanoliposomes were prepared by the reverse-phase evaporation method. They were then characterized, and the results showed that the size, size distribution, and zeta potential of the nanoformulation were 129.1 ± 5.5 nm, 0.240 ± 0.13, and À18.9 6 0.31 mv, respectively. Also, the encapsulation and loading efficiencies of MEL in the nanoparticles were determined to be 98.3 ± 2.1% and 5.2 ± 1.3%, respectively. Also, the drug release pattern was evaluated using a dialysis bag method, and the results demonstrated that 20.5% of MEL was released after 48 h from the nanoparticles, which was 2.7-fold slower compared to when the standard drug was used. In addition, the effects of the standard drug and nanoformulation on cell viability was assessed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the results showed that nanoformulation had 1.4-fold more toxicity than the standard drug. Moreover, the extent of apoptosis was investigated using the Annexin-propidium iodide kit and flow cytometry method. The results showed that MEL-loaded PEGylated nanoliposomes increased the apoptotic cells compared to the control group.

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Mesoporous silica nanoparticles: synthesis methods and their therapeutic use-recent advances

Cited by 72 publications

References 340 publications

Enhancing the Efficacy of Albendazole for Liver Cancer Treatment Using Mesoporous Silica Nanoparticles: An In Vitro Study

Enhancing the Efficacy of Albendazole for Liver Cancer Treatment Using Mesoporous Silica Nanoparticles: An In Vitro Study

Kidney-Protector Lipidic Cilastatin Derivatives as Structure-Directing Agents for the Synthesis of Mesoporous Silica Nanoparticles for Drug Delivery

Investigation of characterization and cytotoxic effect of PEGylated nanoliposomal containing Melphalan on ovarian cancer: an in vitro study

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