Mesoporous silica nanoparticles incorporated with zinc oxide as a novel antifungal agent against toxigenic fungi strains

Savi, Geovana D.; Zanoni, Élton Torres; Furtado, Bianca Guimarães; Souza, Hilária Mendes de; Scussel, Rahisa; Machado-de-Ávila, Ricardo Andrez; Angioletto, Elídio

doi:10.1080/03601234.2022.2041955

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…Savi et al. (2022) demonstrated that MSNs incorporated with zinc oxide (MSNs‐ZnO, 1.0 mg/mL) can affect the growth of F. graminearum and the production of DON. Zha et al.…”

Section: Don Biological Detoxification Methods and Nutritional Mitiga...mentioning

confidence: 99%

“…In recent years, some studies have shown that nanoparticles are an effective, green, and pollution-free means to control mycotoxins. Savi et al (2022) found that mesoporous silica nanoparticles (MSNs) incorporated with zinc oxide (MSNs-ZnO) had a better antifungal ability, inhibiting the growth of F. graminearum (81%) after treatment with a high concentration of MSNs-ZnO (1.0 mg/mL), destroying the morphology of the fungus, and reducing DON production with a degradation rate of 89% (decrease 4ug/mL). Selenium nanoparticles (100 mg/mL) derived from Trichoderma harzianum JF309 have been proven to significantly improve the control functionalities against F. graminearum (76%), which may be due to the interaction of multiple substances to change the arrangement and movement of the original state, from random, nondirective to regulatory, thereby improving the antifungal ability.…”

Section: Other Biological Antifungal Agentsmentioning

confidence: 99%

“…Moreover, other added forms of Zn have been reported. Savi et al (2022) demonstrated that MSNs incorporated with zinc oxide (MSNs-ZnO, 1.0 mg/mL) can affect the growth of F. graminearum and the production of DON. Zha et al (2021) indicated that the baicalin-zinc complex (4 mg/kg DON and 0.5% baicalin zinc [BZN] basal diet) can alleviate the inflammatory response and modulate the secretion of hormones related to growth axis secretion in piglets.…”

Section: Vitamins and Microelementsmentioning

confidence: 99%

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Global distribution, toxicity to humans and animals, biodegradation, and nutritional mitigation of deoxynivalenol: A review

Liu

Cai

et al. 2023

Comp Rev Food Sci Food Safe

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Deoxynivalenol (DON) is one of the main types of B trichothecenes, and it causes health‐related issues in humans and animals and imposes considerable challenges to food and feed safety globally each year. This review investigates the global hazards of DON, describes the occurrence of DON in food and feed in different countries, and systematically uncovers the mechanisms of the various toxic effects of DON. For DON pollution, many treatments have been reported on the degradation of DON, and each of the treatments has different degradation efficacies and degrades DON by a distinct mechanism. These treatments include physical, chemical, and biological methods and mitigation strategies. Biodegradation methods include microorganisms, enzymes, and biological antifungal agents, which are of great research significance in food processing because of their high efficiency, low environmental hazards, and drug resistance. And we also reviewed the mechanisms of biodegradation methods of DON, the adsorption and antagonism effects of microorganisms, and the different chemical transformation mechanisms of enzymes. Moreover, nutritional mitigation including common nutrients (amino acids, fatty acids, vitamins, and microelements) and plant extracts was discussed in this review, and the mitigation mechanism of DON toxicity was elaborated from the biochemical point of view. These findings help explore various approaches to achieve the best efficiency and applicability, overcome DON pollution worldwide, ensure the sustainability and safety of food processing, and explore potential therapeutic options with the ability to reduce the deleterious effects of DON in humans and animals.

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“…Savi et al. (2022) demonstrated that MSNs incorporated with zinc oxide (MSNs‐ZnO, 1.0 mg/mL) can affect the growth of F. graminearum and the production of DON. Zha et al.…”

Section: Don Biological Detoxification Methods and Nutritional Mitiga...mentioning

confidence: 99%

Section: Other Biological Antifungal Agentsmentioning

confidence: 99%