Mesoporous silica nanoparticles in drug delivery and biomedical applications

Wang, Ying; Zhao, Qinfu; Han, Ning; Bai, Ling; Li, Jia; Liu, Jia; Che, Erxi; Hu, Liang; Zhang, Qiang; Jiang, Tongying; Wang, Siling

doi:10.1016/j.nano.2014.09.014

Cited by 1,005 publications

(623 citation statements)

References 105 publications

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“…Novel drug delivery systems have been synthesized based on mesoporous stimuli responsive silica coatings. [647] In this case, therapeutic cargos are capable of releasing their payloads due to the presence of organic or inorganic moieties [640] www.advancedsciencenews.com www.advhealthmat.de that are responsive to a certain stimuli. [648] Special gate keepers such as coumarin molecules, [649] azobenzene molecules, [650] thymine, [651] and polymers [652] which are responsive to light source as well as grafting of thermosensitive polymers based on poly-N-isopropylacrylamide (PNIPAM) and its derivatives [652,653] have been exploited for a very precise control release of therapeutics in mesoporous silica coated nanoparticles.…”

Section: Magnetic Drug Targetingmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Magnetic Drug Targetingmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

193

171

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“…These green synthesized nanoparticles can beat a portion of the footraces in predictable treatment and diagnostic therapies. The nanoparticles maintain a site specific and targeted activity that increases the efficacy of the drug, as the nanoparticles can avoid immune responses and cross the impermeable membranes [12] and therefore can be valuable for combating cancer. Metal nanoparticles possess surface plasmon resonance in UV-visible regions due to the coherent presence of free electrons in the conduction band, while dielectric constant, size and particle surroundings determine the band shift [13].…”

Section: Synthesis Of Nanoparticles Via Biological Chemical and Physmentioning

confidence: 99%

Bio-Synthesized Silver Nanoparticles Using Different Plant Extracts as Anti-Cancer Agent

Khan¹,

Numan²,

M³

et al. 2017

J Nanomedine Biotherapeutic Discov

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“…As past study reported, silicate is naturally inorganic corrosion inhibitor that has been used in various applications, such as antifreeze in the engine, which helps prevent corrosion and as an engine coolant and lubricant [5]. Apart from its application as corrosion inhibitor, silicate extracted from rice husk can be manipulated into a lot of applications and fit into today's high technology advancement, for instance, fillers in high durability concrete and structures [6,7], drug delivery and biomedical applications [8], and many more.…”

Section: Introductionmentioning

confidence: 99%

Nano-Silicate from Paddy Waste as Natural Corrosion Inhibitor

Othman¹,

Awizar²,

Dasuki³

2017

Rice - Technology and Production

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The highly advance usage of an agricultural waste of rice husk ash (RHA) from Oryza sativa L. was developed by extracting the nanosilicate contained in RHA as a corrosion inhibitor for carbon steel in 0.5 M NaCl media. The corrosion measurement was studied using weight loss, potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), surface analysis, and adsorption isotherm study. The extracted nanosilicate powder from RHA was analyzed using Fourier Transform Infrared Spectroscopy (FTIR) to identify the presence of functional groups (SiO 2 ), whereas X-ray diffraction (XRD) to identify the phase of silica from RHA. The particle size of nanosilicate was confirmed by transmission electron microscopy (TEM) and Zetasizer analysis, and the results show particle size of nanosilicate in the range of 5-10 nm. The maximum inhibition efficiency (IE%) is up to 88% in NaCl media. On the other hand, the inhibitor adsorption properties follow Temkin isotherm with mixed type of inhibition properties. Surface analysis on specimen that was treated with nanosilicate was smoother with fewer pits and pores than untreated specimen. In future perspectives, nanosilicate from RHA has a promising advantages and imminent applications for industries revolving with composites, biomedicine, and many more.

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Mesoporous silica nanoparticles in drug delivery and biomedical applications

Cited by 1,005 publications

References 105 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Bio-Synthesized Silver Nanoparticles Using Different Plant Extracts as Anti-Cancer Agent

Nano-Silicate from Paddy Waste as Natural Corrosion Inhibitor

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