Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel

Abstract

Mesoporous silica nanoparticles (MSNs) are known as carriers with high loading capacity and large functionalizable surface area for target-directed delivery. In this study, a series of docetaxel-loaded folic acid- or methionine-functionalized mesoporous silica nanoparticles (DTX/MSN-FA or DTX/MSN-Met) with large pores and amine groups at inner pore surface properties were prepared. The results showed that the MSNs were successfully synthesized, having good pay load and pH-sensitive drug release kinetics. The cellular investigation on MCF-7 cells showed better performance of cytotoxicity and cell apoptosis and an increase in cellular uptake of targeted nanoparticles. In vivo fluorescent imaging on healthy BALB/c mice proved that bare MSN-NH2 are mostly accumulated in the liver but MSN-FA or MSN-Met are more concentrated in the kidney. Importantly, ex vivo fluorescent images of tumor-induced BALB/c mice organs revealed the ability of MSN-FA to reach the tumor tissues. In conclusion, DTX/MSNs exhibited a good anticancer activity and enhanced the possibility of targeted drug delivery for breast cancer.

Antimicrobial photodynamic activity of toluidine blue encapsulated in mesoporous silica nanoparticles againstPseudomonas aeruginosaandStaphylococcus aureus

“…The extra peaks, apart from the MSN peaks, in TB MSN at 2,830, 2,910 and 3,518 cm À1 clearly show the presence of TB in MSN. These peaks of TB and MSN agree well with previous reports (Ganguly et al 2013;Nakanishi et al 2015;Khosraviyan et al 2016). HR-TEM micrographs revealed the size, shape, and dispersity of TB MSN.…”

Partitioning of water‐soluble vitamins in biodegradable aqueous two‐phase systems: Electrolyte perturbed‐chain statistical associating fluid theory predictions and experimental validation

“…5 Water-soluble vitamins have many applications and they were willingly applied among others as model drugs/ligands in controlledrelease and targeting drug-delivery studies. [20][21][22] Being low watersoluble and ionizable components, many vitamins face similar problems compared to active pharmaceutical ingredients, 23 for example, low solubility, partial dissociation in aqueous systems. Additionally, watersoluble vitamins are appropriate model compounds to prove the ability of separation by ATPS caused by the high diversity of the molecular structures and properties of these vitamins.…”

Drug delivery approaches for breast cancer

“…[12][13][14] Recently, nextgeneration nano-formulated platinum-based drug delivery has been used in clinics for cancer. 15 The receptor (HER-2, epidermal growth factor receptor [EGFR], vascular endothelial growth factor receptor [VEGFR], insulin-like growth factor I receptor [IGF-IR])-based targeting is the approach which is correlated with the breast tumorigenesis and is undergoing clinical trials (Phases II and III).…”