Mesoporous silica incorporated PCL/Curcumin nanofiber for wound healing application

Rathinavel, S.; Korrapati, Purna Sai; Kalaiselvi, Periandavan; Dharmalingam, Sangeetha

doi:10.1016/j.ejps.2021.106021

Cited by 44 publications

(20 citation statements)

References 80 publications

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“…The diabetes in mice is chemically induced due to the ablation of β-cells by STZ (a nitrosourea analogue, one of the most potent diabetogenic chemicals) ( Al-Awar et al, 2016 ), and such a diabetic mouse model has been substantially used in the field of diabetes research ( Pandey and Dvorakova, 2020 ). Recently, a variety of drug delivery systems have been designed and applied for delivery of therapeutic agents in wound repair and regeneration ( Manconi et al, 2018 ) ( Orsu et al, 2021 ) ( Li et al, 2021b ) ( Rathinavel et al, 2021 ). Previously, a hydrogel was produced in our laboratory by crosslinking a HA polymer ( Mw = 1,800–2,200 kDa) ( Yang et al, 2021a ).…”

Section: Resultsmentioning

confidence: 99%

Local Administration of Ginkgolide B Using a Hyaluronan-Based Hydrogel Improves Wound Healing in Diabetic Mice

Wang¹,

Xia²,

Han³

et al. 2022

Front. Bioeng. Biotechnol.

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Section: Resultsmentioning

confidence: 99%

Local Administration of Ginkgolide B Using a Hyaluronan-Based Hydrogel Improves Wound Healing in Diabetic Mice

Wang¹,

Xia²,

Han³

et al. 2022

Front. Bioeng. Biotechnol.

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“…are among the materials that have long been used in wound dressings to prevent bacterial infections and accelerate wound healing. 108 Also, in many studies, the use of liposomes, 109 mesoporous silica, 110 and drug‐containing nanomaterials 111 , 112 have shown promising results. Recently, the use of carbon nanomaterials such as carbon nanotubes, graphene, and graphene oxide (GO) with unique physicochemical properties in modern wound dressings have been investigated, which are briefly discussed below.…”

Section: Wound Dressingsmentioning

confidence: 99%

Emerging treatment strategies in wound care

Mirhaj

Labbaf

Tavakoli

et al. 2022

International Wound Journal

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Wound healing is a complex process in tissue regeneration through which the body responds to the dissipated cells as a result of any kind of severe injury. Diabetic and non-healing wounds are considered an unmet clinical need. Currently, different strategic approaches are widely used in the treatment of acute and chronic wounds which include, but are not limited to, tissue transplantation, cell therapy and wound dressings, and the use of an instrument. A large number of literatures have been published on this topic; however, the most effective clinical treatment remains a challenge. The wound dressing involves the use of a scaffold, usually using biomaterials for the delivery of medication, autologous stem cells, or growth factors from the blood. Antibacterial and anti-inflammatory drugs are also used to stop the infection as well as accelerate wound healing. With an increase in the ageing population leading to diabetes and associated cutaneous wounds, there is a great need to improve the current treatment strategies. This research critically reviews the current advancement in the therapeutic and clinical approaches for wound healing and tissue regeneration. The results of recent clinical trials suggest that the use of modern dressings and skin substitutes is the easiest, most accessible, and most cost-effective way to treat chronic wounds with advances in materials science such as graphene as 3D scaffold and biomolecules hold significant promise. The annual market value for successful wound treatment exceeds over $50 billion US dollars, and this will encourage industries as well as academics to investigate the application of emerging smart materials for modern dressings and skin substitutes for wound therapy.cells therapy, platelet therapy, skin tissue engineering, wound dressing, wound healing Key Messages• treatment of wound healing is currently considered an unmet clinical need • currently heavily under research are growth factors and cytokines released from platelets and leukocytes that have a significant effect on the cellular functions such as migration, differentiation, and proliferation, so they can regulate the wound healing process

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“…Unfortunately, the use of curcumin is limited by its low bioavailability, rapid metabolism, poor solubility, and light sensitivity [ 152 ]. A large number of recent papers [ 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 ] reported the incorporation of curcumin into nanocomposite materials such as nanofibers, nanoparticles, hydrogels, or novel combinations of these. Recently, numerous researchers have developed biocompatible and biodegradable composite nano-fibrous materials and hydrogel systems containing curcumin for wound healing applications, for example as an anti-scar or in chronic wounds [ 166 , 169 ].…”

Section: Natural Herbals and Spices In Wound Healingmentioning

confidence: 99%

“…Recently, numerous researchers have developed biocompatible and biodegradable composite nano-fibrous materials and hydrogel systems containing curcumin for wound healing applications, for example as an anti-scar or in chronic wounds [ 166 , 169 ]. These scaffold systems include polyvinyl pyrrolidone (PVP) [ 169 ], cerium nitrate hexahydrate (Ce(NO3)3·6H2O) [ 170 ], nanofibers of carboxymethyl guargum (CMGG) [ 171 ], electrospun amine-functionalized SBA-15 (Santa Barbara Amorphous) incorporated with PVA (Poly Vinyl Alcohol) [ 172 ], nanofibers of cellulose acetate (CA) integrated with graphene oxide, TiO2 [ 173 ], electrospun fibers comprising SBA-15 (Santa Barbara Amorphous), amine-functionalized SBA-15 polycaprolactone (PCL) [ 174 ], nanofibers of electrospun poly(ε-caprolactone) (PCL), Chitosan (CS) [ 175 ], thermo-sensitive sodium alginate hydrogel cross-linked with poly(N-isopropylacrylamide), and curcumin (Alg-g-pNIPAM) copolymers [ 176 ]. All these nanofibrous scaffolds exhibited high porosity and biocompatible characteristics that enhance the solubility of this hydrophobic drug, aiding its release in a controlled manner [ 176 ].…”

Section: Natural Herbals and Spices In Wound Healingmentioning

confidence: 99%

Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research

et al. 2022

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Wound healing is a complicated process, and the effective management of wounds is a major challenge. Natural herbal remedies have now become fundamental for the management of skin disorders and the treatment of skin infections due to the side effects of modern medicine and lower price for herbal products. The aim of the present study is to summarize the most recent in vitro, in vivo, and clinical studies on major herbal preparations, their phytochemical constituents, and new formulations for wound management. Research reveals that several herbal medicaments have marked activity in the management of wounds and that this activity is ascribed to flavonoids, alkaloids, saponins, and phenolic compounds. These phytochemicals can act at different stages of the process by means of various mechanisms, including anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulating, cell proliferation, and angiogenic effects. The application of natural compounds using nanotechnology systems may provide significant improvement in the efficacy of wound treatments. Increasing the clinical use of these therapies would require safety assessment in clinical trials.

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Mesoporous silica incorporated PCL/Curcumin nanofiber for wound healing application

Cited by 44 publications

References 80 publications

Local Administration of Ginkgolide B Using a Hyaluronan-Based Hydrogel Improves Wound Healing in Diabetic Mice

Local Administration of Ginkgolide B Using a Hyaluronan-Based Hydrogel Improves Wound Healing in Diabetic Mice

Emerging treatment strategies in wound care

Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research

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