Mesoporous Silica as a Carrier for Amorphous Solid Dispersion

Abstract

In the past decade, the discovery of active pharmaceutical substances with high therapeutic value but poor aqueous solubility has increased, thus making it challenging to formulate these compounds as oral dosage forms. The bioavailability of these drugs can be increased by formulating these drugs as an amorphous drug delivery system. Use of porous media like mesoporous silica has been investigated as a potential means to increase the solubility of poorly soluble drugs and to stabilize the amorphous drug delivery system. These materials have nanosized capillaries and the large surface area which enable the materials to accommodate high drug loading and promote the controlled and fast release. Therefore, mesoporous silica has been used as a carrier in the solid dispersion to form an amorphous solid dispersion (ASD). Mesoporous silica is also being used as an adsorbent in a conventional solid dispersion, which has many useful aspects. This review focuses on the use of mesoporous silica in ASD as potential means to increase the dissolution rate and to provide or increase the stability of the ASD. First, an overview of mesoporous silica and the classification is discussed. Subsequently, methods of drug incorporation, the stability of dispersion and, much more are discussed.

Tunable Effect of the Calcination of the Silanol Groups of KIT-6 and SBA-15 Mesoporous Materials

“…With the discoveries of these two mesoporous nanosilica (MNS) materials, a wide range of possibilities has been opened for the application of both SBA-15 [20][21][22][23][24][25][26][27][28] and KIT-6 [29][30][31][32][33][34][35][36][37] in various areas, such as catalysis, adsorption, separation, drug release, optical devices, and sensors,. The development of MNS has involved three distinct generations [38].…”

Cefdinir Inclusion in Mesoporous Silica as Effective Dissolution Enhancer with Improved Physical Stability

“…Figure 3 shows the results of loading cefdinir using different solvents. Although DMSO is the best solvent for cefdinir, the loading percentage obtained with it was very low 0.23%, this can be attributed to the high polarity of this solvent, and therefore its molecules will compete with drug molecules for bonding with silica particles [44]. Whereas, methanol and ethanol performance was also poor.…”

Effect of carrier type and Tween® 80 concentration on the release of silymarin from amorphous solid dispersions

“…The porosity of Syloid® XDP 3150 was determined to have pores smaller than 1 µm (Figure 4), with approximately one-third having pores smaller than 0.01 µm [42]. In contrast, Avicel® PH-102 intra-particle porosity has pores between 1 and 20 µm (defined as macropores because they are bigger than 50 nm [42]).…”

“…One of the missed formulation approaches is in employing carrier-mediated solid dispersions which can be prepared using widely used, conventional pharmaceutical equipment such as mixer-granulator and/or rotor-evaporator [39][40][41]. In particular, mesoporous silica carriers have shown wide applicability and have been used to prepare liquisolid formulations and amorphous solid dispersions [24,42,43].…”