Mesoporous silica aerogel as a drug carrier for the enhancement of the sunscreen ability of benzophenone-3

Li, C.C.; Chen, Y.T.; Lin, Yi‐Chun; Sie, Sian-Yang; Chen-Yang, Y. W.

doi:10.1016/j.colsurfb.2013.11.011

Cited by 40 publications

(18 citation statements)

References 46 publications

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“…Another strategy to improve the effectiveness of sunscreens is the combination of organic and inorganic filters, as performed by Li et al [6,42]. The authors encapsulated BP-3 into the inorganic UV-filter mesopouros silica (MS) by an in-situ sol-gel process using tetraethyl orthosilicate as a precursor and an ionic liquid as solvent and pore-forming agent.…”

Section: Formulation Strategiesmentioning

confidence: 99%

Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

et al. 2017

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Sunscreens are the most common products used for skin protection against the harmful effects of ultraviolet radiation. However, as frequent application is recommended, the use of large amount of sunscreens could reflect in possible systemic absorption and since these preparations are often applied on large skin areas, even low penetration rates can cause a significant amount of sunscreen to enter the body. An ideal sunscreen should have a high substantivity and should neither penetrate the viable epidermis, the dermis and the systemic circulation, nor in hair follicle. The research of methods to assess the degree of penetration of solar filters into the skin is nowadays even more important than in the past, due to the widespread use of nanomaterials and the new discoveries in cosmetic formulation technology. In the present paper, different in vitro studies, published in the last five years, have been reviewed, in order to focus the attention on the different methodological approaches employed to effectively assess the skin permeation and retention of sunscreens.

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Section: Formulation Strategiesmentioning

confidence: 99%

Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

et al. 2017

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“…15 Many cosmetic products, which are therefore released into domestic wastewater, also contain silica particles able to act as light scattering centers protecting the organic molecules from high load of UV energy. Recent studies have been focused on encapsulation or incorporation methods for photostable organic UV absorbers that reduce skin penetration 16 and on the design of effective sunscreen carriers based on emerging technologies in controlled delivery. Among them, immobilization on silica particles of compounds structurally related to cinnamic alcohol was recently proposed.…”

Section: ■ Introductionmentioning

confidence: 99%

Combined Experimental and Computational Investigation of the Fluorescence Quenching of Riboflavin by Cinnamic Alcohol Chemisorbed on Silica Nanoparticles

et al. 2014

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Riboflavin (vitamin B2) is usually present in water courses, lakes, and seas and acts as a photosensitizer in the photo-oxidation of a range of contaminants. However, little is known about the interaction of this compound with aromatics sorbed on silica sediments or on suspended silica particles. This article describes the modification and characterization of silica nanoparticles by condensation of the silanol groups of the particles with E-cinnamic alcohol. The reaction was confirmed by Fourier transform infrared spectroscopy (FTIR), solid-state 13 C and 29 Si crosspolarization magic angle spinning (CPMAS) NMR, reduction of the specific surface area measured by BET, thermal analysis, and fluorescence spectroscopy. Toxicity to the marine bacteria Vibrio fischeri of the modified particles was also measured. Riboflavin fluorescence was quenched in aqueous medium in the presence of dissolved E-cinnamic alcohol or in suspensions of the modified particles. The results are interpreted in terms of formation of 1:1 complexes between the ground states of riboflavin and the free or adsorbed cinnamic alcohol. Density functional theory (DFT) calculations in aqueous medium support the existence of the complex and explain the observed quenching of riboflavin fluorescence upon addition of cinnamic alcohol without affecting the emission maximum of riboflavin. ■ INTRODUCTIONThe photochemistry and photophysics of isoalloxazines (10-substituted 2,3,4,10-tetrahydro-benzo[g]pteridine-2,4-diones), and especially flavins (7,8-dimethyl substituted isoalloxazines), are of considerable interest due to the biological relevance of these compounds. It is widely recognized that the relatively strong fluorescence of flavins makes observation of their spectral and photophysical properties the best tool to evaluate the physical properties of binding sites of flavoproteins.1 The fluorescence of riboflavin (Rf) can be quenched by aromatics by different mechanisms, such as electron transfer, hydrogen bonding, hydrophobic effects, and π−π interaction.2 Binding of riboflavin to hen egg riboflavin-binding protein results in an almost complete quenching of the riboflavin fluorescence, which is attributed to the ground-state π-stacking of the isoalloxazine ring and the aromatic residues.3 π-Stacking of riboflavin with aromatic residues and the concomitant quenching of the riboflavin fluorescence has also been reported for other riboflavin-binding proteins. 4 The remarkably low fluorescence yield of flavin adenine dinucleotide (FAD) with respect to free riboflavin was explained by the coplanar stacking of the flavin and adenine ring systems, most likely through a mechanism of photoinduced electron transfer of a nonfluorescent intramolecular ground-state complex between the isoalloxazine ring and the adenine moiety.5 Binding of Rf to salycilate ion in aqueous solution was also reported to yield a nonfluorescent complex. 6 Besides the biological relevance of Rf, this molecule is usually present in water courses, lakes, and seas 7 and acts as a p...

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“…The sunscreen containing BP-3, BES-1 and BES-2 is abbreviated as BP-3-E, BES-1-E and BES-2-E, respectively. The sunscreen emulsion containing MSBP-2 was also prepared as reported [15].…”

Section: Preparation Of Oil-in-water Sunscreenmentioning

confidence: 99%

“…For comparison with the encapsulated samples, mixtures of MS and BP-3 with the same composition as BES-1 and BES-2 (BES-1-Mix and BES-2-Mix, respectively) were prepared by mixing and milling MS and BP-3 powders. The corresponding BP-3 adsorbed MS (MSBP-2) was prepared as reported [15] for actual comparison.…”

Section: Preparation Of Mesoporous Silica (Ms) and Bp-3 Encapsulated mentioning

confidence: 99%

“…due to their excellent absorption of the UV wavelengths between 290 nm and 400 nm [14]. In this particular work, BP-3 was adsorbed onto mesoporous silica (MSBP-2) and found to increase the solubilization and reduce the crystallization in the sunscreen emulsion to improve its UV-protection ability [15]. Specifically our study showed that not only the in vitro SPF but also the in vitro UV-A values of the MSBP-2-based sunscreen was increased by about 17% more than that of the free BP-3-based sunscreen.…”

Section: Introductionmentioning

confidence: 98%

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Improvement in UV protection retention capability and reduction in skin penetration of benzophenone-3 with mesoporous silica as drug carrier by encapsulation

Lin

Chen

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

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Mesoporous silica aerogel as a drug carrier for the enhancement of the sunscreen ability of benzophenone-3

Cited by 40 publications

References 46 publications

Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

Cutaneous Permeation and Penetration of Sunscreens: Formulation Strategies and In Vitro Methods

Combined Experimental and Computational Investigation of the Fluorescence Quenching of Riboflavin by Cinnamic Alcohol Chemisorbed on Silica Nanoparticles

Improvement in UV protection retention capability and reduction in skin penetration of benzophenone-3 with mesoporous silica as drug carrier by encapsulation

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