Mesoporous nanomaterial-assisted hydrogel double network composite for mixed-mode liquid chromatography

Fan, Fangbin; Lu, Xiaofeng; Wang, Shuai; Wang, Licheng; Liang, Xiaojing; Guo, Yong

doi:10.1007/s00604-021-05094-4

Cited by 13 publications

(6 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In chemical reaction method, the functional groups in the molecular chain of a polymer react with each other to form covalent bonds; examples include the thiololefn click reaction [ 100 ], Schiff base reaction [ 78 ], free-radical polymerization [ 101 ], and hybridization chain reaction [ 31 ]. A gel formed by chemical crosslinking has higher mechanical properties and no melting or dissolving.…”

Section: Crosslinking Methods Of Mesoporous Material-loaded Composite...mentioning

confidence: 99%

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

View full text Add to dashboard Cite

Scientists have been attempting to improve the properties of mesoporous materials and expand their application since the 1990s, and the combination with hydrogels, macromolecular biological materials, is one of the research focuses currently. Uniform mesoporous structure, high specific surface area, good biocompatibility, and biodegradability make the combined use of mesoporous materials more suitable for the sustained release of loaded drugs than single hydrogels. As a joint result, they can achieve tumor targeting, tumor environment stimulation responsiveness, and multiple therapeutic platforms such as photothermal therapy and photodynamic therapy. Due to the photothermal conversion ability, mesoporous materials can significantly improve the antibacterial ability of hydrogels and offer a novel photocatalytic antibacterial mode. In bone repair systems, mesoporous materials remarkably strengthen the mineralization and mechanical properties of hydrogels, aside from being used as drug carriers to load and release various bioactivators to promote osteogenesis. In hemostasis, mesoporous materials greatly elevate the water absorption rate of hydrogels, enhance the mechanical strength of the blood clot, and dramatically shorten the bleeding time. As for wound healing and tissue regeneration, incorporating mesoporous materials can be promising for enhancing vessel formation and cell proliferation of hydrogels. In this paper, we introduce the classification and preparation methods of mesoporous material-loaded composite hydrogels and highlight the applications of composite hydrogels in drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. We also summarize the latest research progress and point out future research directions. After searching, no research reporting these contents was found.

show abstract

Section: Crosslinking Methods Of Mesoporous Material-loaded Composite...mentioning

confidence: 99%

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

View full text Add to dashboard Cite

show abstract

“…It was demonstrated that the novel 2D MOF-FDM-23@silica stationary phase showed better separation performance and stability than most reported MOF-based stationary phases. Apart from this, our group also prepared a series of novel stationary phases by co-modifying the surface of silica with MOFs and polymer [16,17]. For example, Zn-BTC and dual-network hydrogel modifying silica materials were obtained by adding Zn-BTC to the solution, which contained silica and precursor of hydrogel.…”

Section: Introductionmentioning

confidence: 99%

ZIF-8 Assisted Polyacrylamide Functionalized Silica Core-Shell Stationary Phase for Hydrophilic Interaction Liquid Chromatography

Zhang

et al. 2023

Separations

Self Cite

View full text Add to dashboard Cite

A novel ZIF-8 assisted polyacrylamide functionalized silica polar stationary phase was prepared by a facile method of adding ZIF-8 nanoparticles and silica into polyacrylamide (PAM) aqueous solution, and then stirring the mixture until the solution was evaporated absolutely with the help of mechanical agitator. Interestingly, the prepared stationary phase (PAM-Sil@ZIF-8/PAM) showed favorable hydrophilicity, as demonstrated by good separation performance and strong retention ability toward several types of polar compounds, such as amino acids, saccharides, and alkaloids. In addition, PAM-Sil@ZIF-8(50 mg)/PAM showed better separation performance compared with amino-modified silica and Sil/PAM stationary phase due to the addition of ZIF-8. Furthermore, it was demonstrated that the addition of ZIF-8 improved the specific surface area and provided extra interaction sites for the stationary phase and analytes, which is beneficial for the separation of samples. In addition, the column efficiency can reach 7861.9 plates/m for colchicine. Moreover, it exhibited good stability and reproducibility under our operation conditions. In short, a novel stationary phase, which can be used for hydrophilic interaction liquid chromatography, was obtained and proved that the separation performance of polymer modifying silica stationary phase can be greatly improved by the addition of MOF nanoparticles.

show abstract

“…Nowadays, mixed-mode chromatography with multiple retention and excellent separation efficiency has been achieved in one column to separate various types of substances. 10–14…”

Section: Introductionmentioning

confidence: 99%