Mesoporous Materials for Drug Delivery and Theranostics

Abstract

Mesoporous materials, especially those made of silica or silicon, are capturing great interest in the field of nanomedicine [...]

Role of Mesoporous Silica Nanoparticles as Drug Carriers: Evaluation of Diverse Mesoporous Material Nanoparticles as Potential Host for Various Applications

“…This allows for exact checks on the release of cargo using a stimulus, whether internal and pathological characteristics are addressed or whether the physician is external. The regulation provided by the MSNs-responsive mechanism prevents the early release of the therapeutic substance, which could be important in preventing systemic toxicity (Cauda et al 2020;Zhou et al 2018;Vallet-Regí et al 2018). By modifying the physicochemical parameters of the chosen mesoporous materials, the nature of the drug's interactions can be altered.…”

Anticancer Potential of Xanthohumol and Isoxanthohumol Loaded into SBA-15 Mesoporous Silica Particles against B16F10 Melanoma Cells

“…Lately, scientists are making great efforts to improve the delivery and effectiveness of drugs using different approaches such as loading to polylactic acid microspheres, lipid nanoparticles or modifying them by glycosylation [ 36 , 37 , 38 , 39 , 40 ]. One of the possibilities for improving delivery and targeting is the use of mesoporous silica nanoparticles such as nontoxic SBA-15 (Santa Barbara Amorphous 15) [ 41 ]. Recently, it was reported that SBA-15 loaded with cisplatin, organotin (IV) compounds or titanocene dichloride and its derivatives can reduce tumor cell growth [ 42 , 43 , 44 , 45 , 46 ].…”

“…In addition, the apo inducing property of XN is transformed into a preference of autophagic cell death bling tumor repopulation in response to apoptotic-induced cell proliferation, a m nism that is tightly connected with therapy failure in advanced forms of cancer [47 Lately, scientists are making great efforts to improve the delivery and effectiveness of drugs using different approaches such as loading to polylactic acid microspheres, lipid nanoparticles or modifying them by glycosylation [36][37][38][39][40]. One of the possibilities for improving delivery and targeting is the use of mesoporous silica nanoparticles such as nontoxic SBA-15 (Santa Barbara Amorphous 15) [41]. Recently, it was reported that SBA-15 loaded with cisplatin, organotin (IV) compounds or titanocene dichloride and its derivatives can reduce tumor cell growth [42][43][44][45][46].…”

Core–Shell Nanoparticle Combined with Bacterial Targeting and Antibiotic Loading for Bacteria Tracing and Clearing

“…The crucial step in tracing bacteria is the selection of bacteriatracing agents, which include antibodies, [5] sugars, [6] antimicrobial peptides, [7] 67 Ga-citrate, radiolabeled leukocytes, and 18 F-fluorodeoxyglucose (FDG). [8][9][10] Ubiquicidin (UBI) [29][30][31][32][33][34][35][36][37][38][39][40][41] , which contains six positive amino acids, is a synthetic cationic bactericidal peptide fragment and can preferentially bind to the anionic bacterial cell membranes accumulated at the site of infection. [11] Based on this mechanism, UBI 29-41 combined with 99m Tc, 68 Ga, or near-infrared fluorescent dye has been widely investigated for use in the diagnosis of infection or as a target to trace bacteria.…”

“…[11] Based on this mechanism, UBI 29-41 combined with 99m Tc, 68 Ga, or near-infrared fluorescent dye has been widely investigated for use in the diagnosis of infection or as a target to trace bacteria. [12][13][14] Recently, 99m Tc-UBI [29][30][31][32][33][34][35][36][37][38][39][40][41] has been investigated as an adjunct to bone scans to differentiate between infected and aseptic loosening of prostheses before revision surgery. [15][16][17][18] Traditional antibiotics still have many shortcomings in the treatment of infection-related diseases.…”