Mesoporous, degradable hyaluronic acid microparticles for sustainable drug delivery application

Şahiner, Nurettin; Suner, Selin S.; Ayyala, Ramesh S.

doi:10.1016/j.colsurfb.2019.02.015

Cited by 35 publications

(25 citation statements)

References 47 publications

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“…Loading of amoxicillin trihydrate (AMX) drug into inulin cryogel was carried out by employing the chemical conjugation method. The chemical conjugation of AMX was performed following the method reported in the literature 28,30 . Firstly, 0.5 g (1.2 mmol) of AMX was dissolved in 50 mL of DMSO and 0.214 g (1.32 mmol) of 1,1‐Carbonyldiimidazole was added to this drug solution, then it was stirred at room temperature for 2 hours at 500 rpm.…”

Section: Methodsmentioning

confidence: 99%

Biodegradable super porous inulin cryogels as potential drug carrier

Ari

Şahiner

2020

Polymers for Advanced Techs

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Here, chemically crosslinked super porous inulin cryogels were synthesized by the cryogelation method using divinyl sulfone (DVS) at various mol ratios of 75% to 150% inulin repeating units. Inulin cryogel prepared at 75 mol% DVS crosslinking showed a maximum swelling capacity of 1842 ± 159% in phosphate buffer saline (PBS, pH 7.4). The hydrolytic degradation of inulin cryogels prepared at different ratios were investigated at 37.5 Cat pH 1, 7.4, and 9. Depending on the degree of crosslinking, it was found that inulin cryogels were completely degraded in 1 to 6 days at pH 1, and the degradation continued at pH 7.4 and 9 for up to 21 days. Inulin cryogel with 75 mol% crosslinker had 61% ± 7% and 45% ± 2% weight losses at pH 7.4 and pH 9, respectively, at end of 21 days. Also, 75% crosslinked inulin cryogel was conjugated with amoxicillin trihydrate (AMX) drug and released 65.15 ± 5.35 mg/g of AMX at pH 1 at end of 24 hours. At pH 7.4 and 9, the AMX released amount were determined as 64.83 ± 6.19 and 55.57 ± 4.00 mg/g, respectively, in 120 hours. Furthermore, inulin cryogels were determined to be blood compatible materials via hemolytic tests with hemolysis ratio of 1.08% ± 0.14% and a blood clotting index of 80.67% ± 1.86%. K E Y W O R D S biodegradable polymer network, blood compatible drug carrier, inulin cryogel 1 | INTRODUCTION Inulin is a plant-based linear biopolymer naturally occurring in many plants such as chicory, asparagus, wheat, onion, garlic, banana, etc. It is an important agricultural by-product and commonly used in the food sector, drug transport systems, tissue engineering, pharmaceutical and cosmetic products. 1-5 In the food sector, it is used as dietary fiber to increase the nutritional value of products and is one of the most beneficial natural probiotics. 6-11 Additionally, inulin can be considered a renewable material in bioprocesses for biofuel production. The biocompatible, biodegradable, renewable, and hydrophilic structure, along with natural and plant-based origin, make inulin a very attractive material for diverse applications. 12-14 Cryogels are distinctive types of hydrogels with faster response time to external stimuli due to their highly macro porous interconnected matrices that can be obtained by crosslinking monomeric or polymeric precursors in the partially frozen phase under cryogenic conditions. 15,16 The size and the extent of pores in cryogels can be controlled by various parameters, for example, the amount of water, cooling rate, the reaction temperature, monomer/polymer concentration, the amount of crosslinker, the amount of catalyst, etc. 17-21 Ascryogels exhibit faster response time and mechanical strength compared to normal hydrogels, they offer many advantages in common applications including environmentally related, that is, separation, actuation, and sensors, tissue engineering and as cell carrier in biotechnology due to their super-porous structures. 22-27 Moreover, because it is possible to prepare cryogels from natural sources and they are biodegradable, they can...

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Section: Methodsmentioning

confidence: 99%

Biodegradable super porous inulin cryogels as potential drug carrier

Ari

Şahiner

2020

Polymers for Advanced Techs

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“…The amounts of drug released from the drug‐loaded particles were measured by removing a certain amount of solution and measuring the absorbance values via UV–Vis spectroscopy at 282 nm against the earlier constructed calibration curve for sodium diclofenac in PBS solution. In the release studies, measurements were performed three times and data is presented as averages and standard deviations 41 …”

Section: Methodsmentioning

confidence: 99%

“…In the release studies, measurements were performed three times and data is presented as averages and standard deviations. 41 To calculate drug loading amount (mg/g) and drug loading efficiency (%) of bare and modified p(MAL) particles, following equations were used;…”

Section: Drug Loading and Release Studies From P(mal) Particlesmentioning

confidence: 99%

Versatile poly(maltose) micro/nanoparticles with tunable surface functionality as a biomaterial

Kurt

Ayyala

Şahiner

2020

J of Applied Polymer Sci

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Maltose, a natural disaccharide, was crosslinked with divinyl sulfone to prepare poly(maltose) (p(MAL)) micro/nanoparticles via one step microemulsion system with ≥90% ± 5% yield in a size rage of 0.5-100 μm for the first time. P(MAL) was modified (m-p(MAL)) with ethylenediamine (EDA), polyethyleneimine (PEI), and taurine (TA) to render additional functionalities, that is, amine and sulfate groups. The isoelectronic point of bare p(MAL) particles were calculated at pH 2.2 ± 0.5 and was changed to 1.3 ± 0.5, 4.3 ± 1.0, and 8.1 ± 0.7 for TA (p(MAL)/TA), EDA (p(MAL)/EDA), and PEI (p(MAL)/PEI) modification, respectively. Bare p(MAL) particles were found to be biocompatible up to 2 mg/ml with hemolysis and blood clotting tests, whereas the modified p(MAL) particles were found to be biocompatible at 1 mg/ml concentration. Additionally, it was found that TA-and PEI-modified p(MAL) particles induced blood clotting mechanisms. Sodium diclofenac as model drug was released at proportions of 8.7% ± 1.3%, 3.9% ± 0.2%, 8.8% ± 0.9%, and 31.6% ± 0.4% of the loaded drug in phosphate buffered saline solution from p(MAL), p(MAL)/TA, p(MAL)/EDA, and p(MAL)/PEI, respectively. The inhibition of antimicrobial activity of p(MAL)/PEI particles at 20 mg/ml concentration for Escherichia coli and Staphylococcus aureus strain was determined as 99.86% ± 0.3% and 99.79% ± 0.25%, respectively.

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“… [ 132 ] Sodium hyaluronate Vancomycin Drug loading capacity of vancomycin in porous and degradable hyaluronic acid (HA) microparticles were increased by the HA porosity, and the drug release degree could be modified by the degradability of the particles. [ 133 ] Sodium alginate Curcumin Alginate microparticles crosslinked by ion gelation were used for controlled release curcumin solubilized in the lipid phase. [ 134 ] Insulin The efficacy of microparticles prepared using different amounts of mucin and alginate on controlled insulin release was assessed.…”

Section: Micro and Nanoscale Carrier Typesmentioning

confidence: 99%

Micro and nanoscale technologies in oral drug delivery

Ahadian

Finbloom

Mofidfar

et al. 2020

Advanced Drug Delivery Reviews

135

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Micro and nanocarriers Micro and nanoscale technologies Oral drug delivery Tissue models Oral administration is a pillar of the pharmaceutical industry and yet it remains challenging to administer hydrophilic therapeutics by the oral route. Smart and controlled oral drug delivery could bypass the physiological barriers that limit the oral delivery of these therapeutics. Micro-and nanoscale technologies, with an unprecedented ability to create, control, and measure micro-or nanoenvironments, have found tremendous applications in biology and medicine. In particular, significant advances have been made in using these technologies for oral drug delivery. In this review, we briefly describe biological barriers to oral drug delivery and micro and nanoscale fabrication technologies. Micro and nanoscale drug carriers fabricated using these technologies, including bioadhesives, microparticles, micropatches, and nanoparticles, are described. Other applications of micro and nanoscale technologies are discussed, including fabrication of devices and tissue engineering models to precisely control or assess oral drug delivery in vivo and in vitro, respectively. Strategies to advance translation of micro and nanotechnologies into clinical trials for oral drug delivery are mentioned. Finally, challenges and future prospects on further integration of micro and nanoscale technologies with oral drug delivery systems are highlighted.

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Mesoporous, degradable hyaluronic acid microparticles for sustainable drug delivery application

Cited by 35 publications

References 47 publications

Biodegradable super porous inulin cryogels as potential drug carrier

Biodegradable super porous inulin cryogels as potential drug carrier

Versatile poly(maltose) micro/nanoparticles with tunable surface functionality as a biomaterial

Micro and nanoscale technologies in oral drug delivery

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