Mesoporous chitosan nanofibers loaded with norfloxacin and coated with phenylboronic acid perform as bioabsorbable active dressings to accelerate the healing of burn wounds

Ailincai, Daniela; Cibotaru, Sandu; Anisiei, Alexandru; Coman, Corneliu George; Pasca, Aurelian Sorin; Roșca, Irina; Sandu, Andreea-Isabela; Mititelu-Tarțău, Liliana; Marin, Luminița

doi:10.1016/j.carbpol.2023.121135

Cited by 13 publications

(3 citation statements)

References 61 publications

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“…C2′s diffractogram presented three diffraction peaks corresponding to the following distances: (i) 18.02 Å between the hydrophobic layers, (ii) 9.04 Å between two rigid citral moieties grafted on the chitosan backbone and (iii) the last one of 4.4 Å between two chitosan chains within the same layer. The semicrystalline nature of the xerogels and of chitosan was also supported by polarized optical microscopy images, all samples presenting strong birefringence due to their high degree of ordering at a supramolecular level ( Figure 4 c–f) [ 46 ].…”

Section: Resultsmentioning

confidence: 95%

“…The morphological investigations of the xerogels by SEM after being in contact with the mercury acetate solution did not reveal the presence of any mercury acetate crystals on xerogel surfaces or in the pores of the materials, but an increase in the pore walls was observed, the structure becoming more robust. This indicated the predominance of the mercury complexation by the amino, hydroxylic and imine group in the detriment of its physical absorption (Cibotaru et al, 2022 [ 46 ]; Ferraz de Paiva et al, 2017 [ 48 ]; Sultan et al, 2015 [ 47 ]). The quantitative determination of mercury from the samples was evaluated by EDAX.…”

Section: Resultsmentioning

confidence: 99%

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Citryl-Imino-Chitosan Xerogels as Promising Materials for Mercury Recovery from Waste Waters

Ailincai,

Andreica

2023

Polymers

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The present study reported the obtention of xerogels based on chitosan and citral and their use as materials for mercury ion recovery from aqueous solutions, this being a serious problem related to the environment. The systems were prepared by the acid condensation of chitosan with citral, followed by the lyophilization of the resulting hydrogels, in order to obtain highly porous solid materials. The structural, morphological and supramolecular characterization of the systems was performed using 1H-NMR and FTIR spectroscopy, scanning electron microscopy and wide-angle X-ray diffraction. The ability of the obtained materials to be used for the recovery of mercury from aqueous solutions revealed the high potential of the xerogels to be used in this sense, the analysis of the materials post mercury absorption experiments revealing that this ability is predominantly conferred by the imine linkages which act as coordinating moieties for mercury ions.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Citryl-Imino-Chitosan Xerogels as Promising Materials for Mercury Recovery from Waste Waters

Ailincai,

Andreica

2023

Polymers

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“…A considerable amount of work was focused on developing wound dressings based on chitosan, such as hydrogels, membranes, sponges, and fibers, all of which have reported promising results [ 20 , 21 , 22 ]. Among these, chitosan-based nanofibers appear to be the most favorable because of their similarities to the natural extracellular matrix, good absorbency, semipermeability, and exceptional conformability [ 17 , 23 , 24 , 25 , 26 , 27 ]. They can be prepared via electrospinning, a simple, versatile, and green technology, which also has the advantage of leading to lightweight materials that have a high active area and are suitable for wound dressings [ 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Theoretical—Experimental Approach of Chitosan/Quaternized Chitosan Nanofibers’ Behavior in Wound Exudate Media

Andreica,

Anisiei,

Iftime

et al. 2023

Pharmaceutics

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This study aimed to investigate the behavior of chitosan/quaternized chitosan fibers in media mimicking wound exudates to understand their capacities as wound dressing. Fiber analysis of the fibers using dynamic vapor sorption proved their ability to adsorb moisture up to 60% and then to desorb it as a function of humidity, indicating their outstanding breathability. Dissolution analyses showed that quaternized chitosan leached from the fibers in water and PBS, whereas only small portions of chitosan were solubilized in water. In media containing lysozyme, the fibers degraded with a rate determined by their composition and pH, reaching a mass loss of up to 47% in media of physiologic pH. Notably, in media mimicking the wound exudate during healing, they adsorbed moisture even when their mass loss due to biodegradation was high, whereas they were completely degraded in the media of normal tissues, indicating bioabsorbable dressing capacities. A mathematical model was constructed, which characterized the degradation rate and morphology changes of chitosan/quaternized chitosan fibers through analyses of dynamics in scale space, using the Theory of Scale Relativity. The model was validated using experimental data, making it possible to generalize it to the degradation of other biopolymeric systems that address wound healing.

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Janus Nanofiber Membranes with Photothermal‐Enhanced Biofluid Drainage and Sterilization for Diabetic Wounds

Zhang,

Yu,

Ren

et al. 2024

Adv Funct Materials

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Diabetic wounds are difficult to heal, and the key to wound healing is exudate management and effective disinfection. Inspired by the asymmetric wettability of Janus‐structured lotus leaves, herein the study has presented the design of a biomimetic asymmetric Janus membrane that integrates unidirectional biofluid drainage and photothermal‐enhanced evaporation/sterilization capabilities for accelerating diabetic wound healing. This Janus membrane is prepared by electrospinning polyacrylonitrile (PAN) nanofiber membrane containing polydopamine (PDA) on the surface of polypropylene (PP) nonwoven membrane. Such PP/PANx%PDA Janus membrane enables antigravity “pumping” of the water from the hydrophobic PP layer to the hydrophilic PANx%PDA layer within 22 s through contact points on the Janus interface. The incorporation of 30 wt% PDA in PAN imparts high photoabsorption and photothermal responsiveness, facilitating continuous volatilization of the exudate, achieving twice the displacement of water, and causing irreversible damage to bacteria. As a result, it effectively alleviates inflammation and cellular fibrosis while promoting collagen deposition due to its structure and antibacterial properties. Impressively, such photothermal‐enhanced Janus membrane achieves an impressive closure rate of 96.7% for diabetic wounds, better than that of (59.8%) for conventional bandages. Therefore, this asymmetric Janus membrane offers a promising alternative for the healing of chronic diabetic wounds.

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Mesoporous chitosan nanofibers loaded with norfloxacin and coated with phenylboronic acid perform as bioabsorbable active dressings to accelerate the healing of burn wounds

Cited by 13 publications

References 61 publications

Citryl-Imino-Chitosan Xerogels as Promising Materials for Mercury Recovery from Waste Waters

Citryl-Imino-Chitosan Xerogels as Promising Materials for Mercury Recovery from Waste Waters

Theoretical—Experimental Approach of Chitosan/Quaternized Chitosan Nanofibers’ Behavior in Wound Exudate Media

Janus Nanofiber Membranes with Photothermal‐Enhanced Biofluid Drainage and Sterilization for Diabetic Wounds

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