Mesoporous carbon as a novel drug carrier of fenofibrate for enhancement of the dissolution and oral bioavailability

Niu, Xiaohui; Long, Wei; Zhong, Honglin; Wang, Tianyi; Sun, Changshan; Sun, Jin; Zhao, Peng; Jiang, Tongying; Wang, Siling

doi:10.1016/j.ijpharm.2013.05.016

Cited by 55 publications

(36 citation statements)

References 40 publications

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“…[56][57][58] In early reports, MC microparticles were used to improve the oral absorption of water-insoluble drugs with drug-loading content higher than 50%. 57,[59][60][61][62][63][64] …”

Section: Mesoporous Carbon As Carriermentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

419

268

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Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

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“…[56][57][58] In early reports, MC microparticles were used to improve the oral absorption of water-insoluble drugs with drug-loading content higher than 50%. 57,[59][60][61][62][63][64] …”

Section: Mesoporous Carbon As Carriermentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

419

268

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“…However, mesoporous silicas have some drawbacks as their weak stability under extreme pH conditions or the fact that long-term exposure to silica compounds can exert a cytotoxic effect and weaken the immune system [19,20]. Ordered mesoporous carbons (OMCs) overcome the drawbacks of these materials and emerge as highly valuable drug delivery systems because of their well-ordered and tunable pore structure, high pore volumes and specific surface areas, high stability in aqueous media and excellent biocompatibility [21,22]. The surface chemistry of materials used as drug carriers is a key factor in adsorption and release of drugs.…”

Section: Introductionmentioning

confidence: 99%

pH-responsive ordered mesoporous carbons for controlled ibuprofen release

Sánchez-Sánchez

Suárez-Garcı́a

Martı́nez-Alonso

et al. 2015

Carbon

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“…Indeed, we can maintain sink conditions in octanol phase with a low volume of organic solvent. Finally, fenofibrate is soluble in supercritical CO 2 (Chen et al, 2010) and this API is often used in the literature as a model molecule for all processes involving the use of supercritical CO 2 (Dalvi et al, 2013;Hiendrawan et al, 2014;Sanganwar and Gupta, 2008) and for processes that attempt to increase the aqueous solubility of a compound by self-emulsification in a lipid-based formulation (Bahloul et al, 2014;Devraj et al, 2013;Griffin et al, 2014;Mu et al, 2013) or by any other techniques (Dong et al, 2014;Kalivoda et al, 2012;Niu et al, 2013).…”

Section: Introductionmentioning

confidence: 99%