Mesoporous calcium peroxide-ignited NO generation for amplifying photothermal immunotherapy of breast cancer

Hao, Huisong; Yu, Mian; Yi, Yunfei; Sun, Shengjie; Huang, Xiuyu; Huang, Chenyi; Liu, Yuanqi; Huang, Weijian; Wang, Junqing; Zhao, Jing; Wu, Meiying

doi:10.1016/j.cej.2022.135371

Cited by 28 publications

(20 citation statements)

References 57 publications

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“…Innate immune system, the first line of defense for maintaining body homeostasis, which is closely associated with the aforementioned redox homeostasis, also plays a vital role in tumor growth and metastasis. [ 11 ] In TME, tumor‐associated macrophages (TAMs) generally switch to an M2‐like phenotype, which display immunosuppressive, anti‐inflammatory, and tumorigenic functions. Conversely, M1‐like macrophages, which are poorly expressed in TME, not only recognize and destroy malignant tumor cells through phagocytosis, but also initiate adaptive immunity by recruiting and activating other immune cells such as cytotoxic T cells through an antigen presentation process.…”

Section: Introductionmentioning

confidence: 99%

Polypyrrole Nanoenzymes as Tumor Microenvironment Modulators to Reprogram Macrophage and Potentiate Immunotherapy

Zeng

Chen

et al. 2022

Advanced Science

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Nanozyme‐based tumor catalytic therapy has attracted widespread attention in recent years, but its therapeutic outcome is drastically diminished by species of nanozyme, concentration of substrate, pH value, and reaction temperature, etc. Herein, a novel Cu‐doped polypyrrole nanozyme (CuP) with trienzyme‐like activities, including catalase (CAT), glutathione peroxidase (GPx), and peroxidase (POD), is first proposed by a straightforward one‐step procedure, which can specifically promote O 2 and ·OH elevation but glutathione (GSH) reduction in tumor microenvironment (TME), causing irreversible oxidative stress damage to tumor cells and reversing the redox balance. The PEGylated CuP nanozyme (CuPP) has been demonstrated to efficiently reverse immunosuppressive TME by overcoming tumor hypoxia and re‐educating macrophage from pro‐tumoral M2 to anti‐tumoral M1 phenotype. More importantly, CuPP exhibits hyperthermia‐enhanced enzyme‐mimic catalytic and immunoregulatory activities, which results in intense immune responses and almost complete tumor inhibition by further combining with α PD‐L1. This work opens intriguing perspectives not only in enzyme‐catalytic nanomedicine but also in macrophage‐based tumor immunotherapy.

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Section: Introductionmentioning

confidence: 99%

Polypyrrole Nanoenzymes as Tumor Microenvironment Modulators to Reprogram Macrophage and Potentiate Immunotherapy

Zeng

Chen

et al. 2022

Advanced Science

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“…Under ultrasound, the burst oxygen release was triggered to reserve the oxygen loss, thus strengthening the RT-induced DNA damage while simultaneously inhibiting DNA repair. In addition to O 2 delivering, O 2 production in situ by undergoing chemical reactions is also a promising strategy for improved chemotherapy and PDT [ 23 , 24 ]. Hydrogen peroxide (H 2 O 2 ) has been indicated to over-produce in tumor tissue due to abnormal metabolic processes [ [25] , [26] , [27] , [28] , [29] ].…”

Section: Introductionmentioning

confidence: 99%

The development of live microorganism-based oxygen shuttles for enhanced hypoxic tumor therapy

Han

Zhang

et al. 2023

Materials Today Bio

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“…Metal peroxides have attracted particular research interest in biology and medicine due to their peculiar chemical reactions, associated reaction products, and particular biochemical efects of the released metal ions [28,29]. Recently, versatile metal peroxide nanoparticles including CuO 2 , CaO 2 , MgO 2 , ZnO 2 , BaO 2 , and TiOx have been developed for therapeutic applications [30][31][32]. Tese include areas of cancer treatment, bacterial infection prevention, and tissue regeneration, where they have received substantial research attention [33,34].…”

Section: Introductionmentioning

confidence: 99%

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

Mbugua

2022

Bioinorganic Chemistry and Applications

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Solid tumors have a unique tumor microenvironment (TME), which includes hypoxia, low acidity, and high hydrogen peroxide and glutathione (GSH) levels, among others. These unique factors, which offer favourable microenvironments and nourishment for tumor development and spread, also serve as a gateway for specific and successful cancer therapies. A good example is metal peroxide structures which have been synthesized and utilized to enhance oxygen supply and they have shown great promise in the alleviation of hypoxia. In a hypoxic environment, certain oxygen-dependent treatments such as photodynamic therapy and radiotherapy fail to respond and therefore modulating the hypoxic tumor microenvironment has been found to enhance the antitumor impact of certain drugs. Under acidic environments, the hydrogen peroxide produced by the reaction of metal peroxides with water not only induces oxidative stress but also produces additional oxygen. This is achieved since hydrogen peroxide acts as a reactive substrate for molecules such as catalyse enzymes, alleviating tumor hypoxia observed in the tumor microenvironment. Metal ions released in the process can also offer distinct bioactivity in their own right. Metal peroxides used in anticancer therapy are a rapidly evolving field, and there is good evidence that they are a good option for regulating the tumor microenvironment in cancer therapy. In this regard, the synthesis and mechanisms behind the successful application of metal peroxides to specifically target the tumor microenvironment are highlighted in this review. Various characteristics of TME such as angiogenesis, inflammation, hypoxia, acidity levels, and metal ion homeostasis are addressed in this regard, together with certain forms of synergistic combination treatments.

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Mesoporous calcium peroxide-ignited NO generation for amplifying photothermal immunotherapy of breast cancer

Cited by 28 publications

References 57 publications

Polypyrrole Nanoenzymes as Tumor Microenvironment Modulators to Reprogram Macrophage and Potentiate Immunotherapy

Polypyrrole Nanoenzymes as Tumor Microenvironment Modulators to Reprogram Macrophage and Potentiate Immunotherapy

The development of live microorganism-based oxygen shuttles for enhanced hypoxic tumor therapy

Targeting Tumor Microenvironment by Metal Peroxide Nanoparticles in Cancer Therapy

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