Mesopic foveal contrast sensitivity is impaired in diabetic patients without retinopathy

Katz, Gabriel; Levkovitch-Verbin, Hani; Treister, Giora; Belkin, Michael; Ilany, Jacob; Polat, Uri

doi:10.1007/s00417-010-1413-y

Cited by 33 publications

(32 citation statements)

References 16 publications

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“…49 Impaired visual function preceding clinically visible DR has also been observed in some population-based studies. 50,51 In the present study, we demonstrated with noninvasive SS-OCTA that CC perfusion reduction may precede retinal vascular changes in the macula of diabetic eyes. Although the outer retina receives most of its blood supply from the CC, 52 whether reduced perfusion contributes to abnormal visual function in diabetic patients before overt retinopathy still requires further investigation.…”

Section: Meansupporting

confidence: 53%

Microvascular Changes in the Choriocapillaris of Diabetic Patients Without Retinopathy Investigated by Swept-Source OCT Angiography

Dai

Zhou

Chu

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Purpose To investigate the microvascular changes in macular retina and choriocapillaris (CC) in diabetic eyes without retinopathy using swept-source optical coherence tomography angiography (SS-OCTA). Methods A commercial SS-OCTA system was used to collect 6 × 6-mm macular scans from patients. Three depth-resolved retinal slabs and a CC slab were segmented by a validated semiautomated algorithm. Retinal vessel area density, vessel skeleton density, and nonperfusion area were calculated on segmented retinal slabs. Foveal avascular zone was automatically measured based on en face image of the whole retinal layer. For CC quantification, the percentage of flow deficits (FD%) and the flow deficit (FD) sizes were measured. Results Sixteen eyes from 16 diabetic patients without clinically detectable retinopathy and 16 eyes from 16 age-matched nondiabetic controls were included. There was no significant difference between the two groups in all retinal vessel quantitative parameters (all P > 0.05). However, the mean FD% and mean FD sizes were significantly increased in CC in the central 1.0-mm disk ( P = 0.011 and P = 0.017, respectively), the central 1.5-mm rim ( P = 0.003 and P = 0.009, respectively), the central 2.5-mm rim ( P = 0.018 and P = 0.020, respectively), and the entire 5.0-mm disk ( P = 0.009 and P = 0.008, respectively) in diabetic eyes compared with controls. Conclusions CC perfusion in the macula is decreased in diabetic patients without retinopathy as compared to age-matched normal controls. Decreased CC perfusion in the macula may be an early indicator of otherwise clinically undetectable diabetic vasculopathy.

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Section: Meansupporting

confidence: 53%

Microvascular Changes in the Choriocapillaris of Diabetic Patients Without Retinopathy Investigated by Swept-Source OCT Angiography

Dai

Zhou

Chu

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…Contrast sensitivity was assessed in middle‐aged people with or without diabetes who had no eye disease. Those with diabetes had reduced contrast sensitivity . Worryingly, impaired contrast sensitivity occurs in young people.…”

Section: Contrast Sensitivitymentioning

confidence: 97%

‘I cried for my lost sight.’ Vision and diabetes

Hillson¹

2016

Pract Diab

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“…Sometimes a deficit in contrast sensitivity was found, whereas visual acuity was reported as normal. The difference between visual acuity and contrast sensitivity is especially apparent in clinical cases such as myopia, early cataracts 14 , congenital glaucoma 14 , and the initial stages of diabetic retinopathy 15 .…”

Section: Monocular and Binocular Temporal Visual Perception Of Infantmentioning

confidence: 99%

Monocular and Binocular Temporal Visual Perception of Infantile Nystagmus

Moshkovitz

Lev

Polat

2020

Sci Rep

Self Cite

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duration, is defined as the point at which further stimulus presentation time does not contribute to enhanced performance 6,24. In some studies, critical duration refers to the time in which contrast sensitivity reaches 90% of the maximal value 24,25. Critical duration can be influenced by spatial and temporal parameters. Studies suggest that the period of temporal integration is affected by spatial frequency; the higher the spatial frequency is, the longer will be the time needed for integration 19. In the literature, the range of critical duration is between 160 and 200 19,26. In addition, critical duration can change as a result of cortical deprivation in cases such as amblyopia 27-31 or neurological disease 29. Nystagmus is a form of spontaneous oscillation of the eyes, which results in excessive motion of images on the retina, accompanied by poor vision including a reduction in visual acuity 32-35. In normal fixation, the eyes are not still; they move at a velocity of 3 minutes of arc in one second 36. Infantile nystagmus (IN) is accompanied by reduced vision in both eyes during the critical periods of life 37-39. The prevalence of infantile nystagmus is 1 to 1000-6000 34,35. The most common form of infantile nystagmus is afferent nystagmus; it is caused by impairment of central vision in early life, e.g., albinism or congenital cataract 35,40. Albinism is a heterogeneous group of congenital disorders affecting melanin synthesis. A few weeks after birth, nystagmus can appear in albino subjects 41. In research investigating nystagmus, albinos are one of the main participants 42-44. In addition, if efferent, it is an idiopathic nystagmus, without any involvement of ocular or systemic pathology. The onset is about 2-3 months after birth and it persists throughout life 45,46. In cases of nystagmus, contrast sensitivity is reduced 35,40,47-49. Vision impairment of cortical origin, such as amblyopia, is characterized by deficits in normal processing such as binocular summation and critical duration. In this study we investigated how binocular and monocular processing was affected in IN due to visual impairment. We hypothesized that in nystagmus, similarly to amblyopia, we would observe absent or diminished binocular summation from the two eyes, and that the critical duration differs from normal sighted vision.

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Mesopic foveal contrast sensitivity is impaired in diabetic patients without retinopathy

Abstract: Mesopic foveal CS is impaired in diabetic patients despite good visual acuity, a normal fundus examination and normal OCT. Early central visual function impairment may occur in diabetic patients before the appearance of retinopathy.

Cited by 33 publications

References 16 publications

Microvascular Changes in the Choriocapillaris of Diabetic Patients Without Retinopathy Investigated by Swept-Source OCT Angiography

Microvascular Changes in the Choriocapillaris of Diabetic Patients Without Retinopathy Investigated by Swept-Source OCT Angiography

‘I cried for my lost sight.’ Vision and diabetes

Monocular and Binocular Temporal Visual Perception of Infantile Nystagmus

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