Mesonephroma of the ovary.A clinical, morphological, and histogenetic appraisal

Abstract

The clinical and morphological aspects of 32 ovarian tumors of the type considered to be of mesonephric origin have been studied and compared with carcinoma of the endometrium and carcinomas generally considered to arise from the surface covering cells of the ovary. An origin from pluripotential surface epithelium of the ovary or displaced endometrium is supported by a variety of findings: 1. mixed histologic pattern; 2. association with endometriosis, endometrioid carcinoma, and malignant transformation of the surface‐covering cells of the ovary, and 3. histologic similarity to clear cell endometrial carcinoma and of their metastases to papillary cystadenocarcinoma of the ovary.

Clear cell ovarian adenocarcinoma

“…There also appears to be a racial predilection, as the vast majority of cases were seen in Caucasians. Presenting symptoms of our patients were similar to those seen in other series [3, 6,8,9,11] and observed with other epithelial ovarian carcinomas. HypercaIcemia was observed in two cases.…”

“…Five patients had adenomyosis and ten had endometriosis. In seven cases, endometriosis was found coexisting with clear cell adenocarcinoma in the same ovary, and in three cases there was evidence that tumor may have arisen from endometriosis, This association has been observed by other authors [1,3,4,6,8,9,13,14,19]. Overall, 26% of the cases have had coexistent endometriosis, and in 22% two lesions have been found in the same ovary (Table X).…”

Optimal cytoreduction is the only independent prognostic factor for survival in women with ovarian clear cell carcinoma

“…In the present study, the median age at diagnosis (54 years) was similar to that reported in many previous studies (11)(12)(13). Besides, 15.3 % of patients were nulliparous however nulliparity has been reported to account for more than 50% of all cases in majority of the studies with the exception of the two reports (17% and 45%, respectively) (12,13). The reported incidence of endometriosis in patients with OCCC ranges from 8% to 55% (14)(15)(16).…”

“…Ovarian clear cell carcinomas are rare tumors that have poorer outcomes and considered as one of the most aggressive ovarian tumor for they are potentially resistant to traditional platinum-based CT (5,10). In the present study, the median age at diagnosis (54 years) was similar to that reported in many previous studies (11)(12)(13). Besides, 15.3 % of patients were nulliparous however nulliparity has been reported to account for more than 50% of all cases in majority of the studies with the exception of the two reports (17% and 45%, respectively) (12,13).…”

Clear cell carcinoma of the ovary: evaluation of prognostic parameters based on a clinicopathological analysis of 100 cases

“…Six of these studies demonstrated an association between architectural pattern and prognosis; [14][15][16][17][18][19] however, statistical significance was only achieved in two. 17,19 Improved survival was seen with a tubulocystic pattern in two studies, 15,17 a 'clear cell pattern' (as opposed to a 'tubular pattern' or 'glandular pattern') in two studies, 14,18 a papillary pattern in one study 16 and a solid pattern comprising <50% of the tumour in the last study. 19 Two additional studies showed a correlation between cell type and outcome; however, neither achieved statistical significance.…”