Mesonephric Adenocarcinoma of the Uterine Corpus: Report of 2 Cases and Review of the Literature

Abstract

Mesonephric adenocarcinoma (MNA) is believed to arise from benign mesonephric remnants or hyperplasia located in the lateral walls of the uterine cervix. They are uncommon in other sites of the gynecologic tract, and exceptionally rare in the uterine corpus. So far, only 30 cases of uterine MNA have been reported in the literature, as a result, the etiology, clinical behavior, choice of treatment, and histogenesis of uterine MNA are still unclear. In this study, we report 2 cases of MNA of uterine corpus. One case involved the inner half of myometrium with endometrial involvement; the second case involved the outer half of myometrium without endometrial involvement. We also reviewed the clinical and pathologic presentations of this rare entity, and discussed the histogenesis of uterine corpus MNA based on recent molecular findings.

Mesonephric-like adenocarcinoma of the ovary with co-existent endometriosis: A case report and review of the literature

“…The diagnosis of either true mesonephric adenocarcinoma or MLA is challenging on biopsy materials and frozen sections as it shares many similar features to clear cell carcinoma, serous carcinoma, endometrial carcinoma and carcinosarcoma. However, true mesonephric adenocarcinoma and MLA will display limited pseudo-stratification a single layer off cuboidal lining and the presence of eosinophilic secretion in the lumen ( Zhang, 2019 ). To reiterate, the terminology of ‘mesonephric-like’ adenocarcinoma is being used when describing tumors of primary ovarian or endometrial origin, as the etiology of these tumors outside of the cervix is only recently described and the histogenesis is not proven.…”

Ovarian mesonephric-like adenocarcinoma arising in serous borderline tumor: a case report with complex morphological and molecular analysis

“…Mesonephric-like adenocarcinomas (M-LAC) are rare, recently described tumors occurring in the uterine corpus and ovary, which share the same morphological and immunohistochemical features with more common mesonephric adenocarcinoma (MAC), most commonly arising in the uterine cervix [ 1 – 5 ]. Despite the similarities between these tumors, the histogenesis of M-LAC is still disputable, as this type of tumor occurs outside the anatomical areas in which mesonephric remnants/hyperplasia may normally occur.…”

Cervical Mesonephric Adenocarcinoma: A Case Report of a Rare Gynecological Tumor from Embryological Remains of the Female Genital Tract

“…10,13 Benign proliferative mesonephric lesions include a scope of symptomatic lesions associated to a diffuse hyperplastic process that may have a deeply infiltrative appearance, like hyperplasia of mesonephric remnants. 7,13 They are unusual conditions that are the common origin of mesonephric carcinomas, and demand a differential diagnosis from it. 7,13 The cytological and architectural features are the base for the mesonephric adenocarcinoma diagnosis.…”

“…7,13 They are unusual conditions that are the common origin of mesonephric carcinomas, and demand a differential diagnosis from it. 7,13 The cytological and architectural features are the base for the mesonephric adenocarcinoma diagnosis. For this reason, it is fundamental that the clinical approach allows for obtaining tumor biopsies.…”