2018
DOI: 10.1101/272963
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Mesolimbic dopamine projections mediate cue-motivated reward seeking but not reward retrieval

Abstract: Efficient foraging requires an ability to coordinate discrete reward-seeking and reward-retrieval behaviors. We used pathway-specific chemogenetic inhibition to investigate how mesolimbic and mesocortical dopamine circuits contribute to the expression and modulation of reward seeking and retrieval. Inhibiting ventral tegmental area dopamine neurons disrupted the tendency for reward-paired cues to motivate reward seeking, but spared their ability to increase attempts to retrieve reward. Similar effects were pro… Show more

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Cited by 6 publications
(8 citation statements)
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“…To elucidate the causal roles of distinct prefronto-subcortical pathways in macaque monkeys, in other words, the pathways from PFC to CD (PFC-CD) and from PFC to MD (PFC-MD), we applied one of the chemogenetic tools, designer receptors exclusively activated by designer drugs (DREADDs). While neuronal silencing can be achieved by activating an inhibitory DREADD (hM4Di) following systemic agonist delivery (24), activating hM4Di expressed at axon terminals through local agonist infusion also leads to suppression of synaptic transmission (25)(26)(27)(28)(29). Here we developed imagingguided chemogenetic synaptic silencing -a methodology for silencing neural pathways selectively with an agonist infused at hM4Di-positive PFC projection sites that are mapped in vivo beforehand by using positron emission tomography (PET) (30).…”
Section: Introductionmentioning
confidence: 99%
“…To elucidate the causal roles of distinct prefronto-subcortical pathways in macaque monkeys, in other words, the pathways from PFC to CD (PFC-CD) and from PFC to MD (PFC-MD), we applied one of the chemogenetic tools, designer receptors exclusively activated by designer drugs (DREADDs). While neuronal silencing can be achieved by activating an inhibitory DREADD (hM4Di) following systemic agonist delivery (24), activating hM4Di expressed at axon terminals through local agonist infusion also leads to suppression of synaptic transmission (25)(26)(27)(28)(29). Here we developed imagingguided chemogenetic synaptic silencing -a methodology for silencing neural pathways selectively with an agonist infused at hM4Di-positive PFC projection sites that are mapped in vivo beforehand by using positron emission tomography (PET) (30).…”
Section: Introductionmentioning
confidence: 99%
“…The mesolimbic system, originating from the ventral tegmental area (VTA) dopaminergic (DA) neurons which project to the nucleus accumbens (NAc), has been extensively involved in regulating motivated behaviors related to reward stimuli and reward-predictive cues (Halbout et al, 2019;Ostlund et al, 2014;Wassum et al, 2013;Yuan et al, 2019), and its abnormalities are associated with Depressive-like behaviors (Krishnan et al, 2007;Chaudhury et al, 2013;Cao et al, 2010). The VTA-NAc pathway does not regulate reward-related behaviors as an independent brain structure, but functions as part of an overlapping and interacting neural circuit.…”
Section: Introductionmentioning
confidence: 99%
“…The alpha level for all tests was .05. Sample sizes were not predetermined based on statistical analysis but are similar to those reported in previous publications (Marshall and Ostlund, 2018;Halbout et al, 2019;Marshall et al, 2020). Main effects and interactions are reported as the results of ANOVA F-tests (i.e., whether the coefficients for each fixed effect were significantly different from 0).…”
Section: Discussionmentioning
confidence: 99%
“…Pre-CS (baseline) data were averaged across all CS trials (within subject). Food-port entry behavior can fall into two categories: spontaneous entries and entries that are performed as part of an instrumental press-entry action sequence (Marshall and Ostlund, 2018;Halbout et al, 2019;Marshall et al, 2020), the latter indicated by an increased likelihood of food-port entry shortly after execution of the lever-press response. To focus our analysis on cue-elicited (and not instrumental) reward-retrieval behavior, we excluded all entries that occurred within a 2.5 sec postlever press period from our analysis, as in our previous studies (Marshall and Ostlund, 2018;Halbout et al, 2019;Marshall et al, 2020)…”
Section: Discussionmentioning
confidence: 99%
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