Abstract. Large parts of Central Europe have experienced exhumation in Late Cretaceous to Paleogene time. Previous studies mainly focused on thrusted basement uplifts to unravel magnitude, processes and timing of exhumation. This study provides, for the first time, a comprehensive thermochronological dataset from mostly Permo-Triassic strata exposed adjacent to and between the basement uplifts in central Germany, comprising an area of at least some 250–300 km across. Results of apatite fission track and (U-Th)/He analyses on > 100 new samples reveal that (i) km-scale exhumation affected the entire region, (ii) thrusting of basement blocks like the Harz Mountains and the Thuringian Forest focused in the Late Cretaceous (about 90–70 Ma) while superimposed domal uplift of central Germany is slightly younger (about 75–55 Ma), and (iii) large parts of the domal uplift experienced removal of 3 to 4 km of Mesozoic strata. Using spatial extent, magnitude and timing as constraints suggests that thrusting and crustal thickening alone can account for no more than half of the domal uplift. Most likely, dynamic topography caused by upwelling asthenosphere has contributed significantly to the observed pattern of exhumation in central Germany.