Mesna (2-mercaptoethane sulfonate) prevents ischemia/reperfusion induced renal oxidative damage in rats

Kabasakal, Levent; Şehirli, Ahmet Özer; Çetınel, Şule; Çikler, Esra; Gedik, Nursal; Şener, Göksel

doi:10.1016/j.lfs.2004.04.029

Cited by 38 publications

(41 citation statements)

References 34 publications

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“…However, recent animal studies demonstrate its antioxidant properties in the amelioration or even prevention of oxidative damage induced by I/R injury in kidneys [19], liver [20], and intestine [21,22]. In our previous study, oral pretreatment with mesna at 400 mg/kg, 3 hours before the induction of 60 min ischemia in the rat jejunum, prevented the induction of oxidative stress, keeping the intestinal mucosa literally intact [22].…”

Section: Discussionmentioning

confidence: 87%

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Mesna protects splanchnic organs from oxidative stress induced by pneumoperitoneum

et al. 2008

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Section: Discussionmentioning

confidence: 87%

“…Apart from its uroprotective action, an antioxidative effect against I/R injury in kidneys [19], liver [20], and intestine [21,22] has also been shown. On these grounds, we sought to investigate a potential beneficial effect of mesna's prophylactic administration against pneumoperitoneum-induced oxidative stress in splanchnic organs.…”

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confidence: 99%

Mesna protects splanchnic organs from oxidative stress induced by pneumoperitoneum

et al. 2008

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“…[29][30][31][32][33][34][35][36][37][38] This transient discontinuation causes renal I/R injury. The pathophysiology following renal I/R injury is not well established.…”

Section: Discussionmentioning

confidence: 99%

Prevention of renal ischemia/reperfusion‐induced injury in rats by leflunomide

Karaman

Türkmen²,

Gürsul

et al. 2006

Int J of Urology

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Objective: There is increasing evidence to suggest that toxic oxygen radicals play an essential role in the pathogenesis of ischemia/ reperfusion (I/R) injury in the kidney. This study was designed to investigate the effects of leflunomide, an isoxazole derivative and a unique immunomodulatory agent, in I/R-induced renal injury in rats. Methods: Forty female Sprague-Dawley rats were divided equally into four groups: (I) control (only leflunomide 10 mg/kg, intragastrically treated); (II) sham operated (only unilateral nephrectomy); (III) I/R; and (IV) leflunomide (10 mg/kg for two doses prior to experiment) plus I/R groups. In groups III and IV, after unilateral nephrectomy, the rats were subjected to 60 min of left renal pedicle occlusion, followed by 6 h of reperfusion. At the end of the reperfusion period, rats were killed and kidneys and blood were removed. Catalase, myeloperoxidase and xanthine oxidase activities, and malondialdehyde, nitric oxide and protein carbonyl levels were determined in renal tissue. Serum creatinine, blood urea nitrogen and aspartate aminotransferase were measured for the evaluation of renal function. In histopathological examination, renal damage was scored 0-3. Results: Group III animals demonstrated severe deterioration of renal function, renal morphology and a significant renal oxidative stress. Pretreatment of animals with leflunomide markedly attenuated renal dysfunction, morphological alterations, reduced elevated oxidative stress products levels and restored the depleted renal antioxidant enzyme. Conclusion:The findings imply that oxygen radicals play a causal role in I/R-induced renal injury, and leflunomide exerts renoprotective effects probably by the radical scavenging and antioxidant activities with immunomodulatory effect.

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“…This drug is used mainly as a mucolytic and antioxidant agent. 18,19 HPLC (high performance liquid chromatography) with amperometric, 20 fluorimetric, 21 mass 22 and ultraviolet 23 detectors have been widely applied as the main methods of detection.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of turbidimetric and nephelometric techniques for analytical determination of n-acetylcysteine and thiamine in pharmaceutical formulations employing a lab-made portable microcontrolled turbidimeter and nephelometer

Santos¹,

Guerreiro²,

Suarez³

et al. 2011

J. Braz. Chem. Soc.

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Mesna (2-mercaptoethane sulfonate) prevents ischemia/reperfusion induced renal oxidative damage in rats

Cited by 38 publications

References 34 publications

Mesna protects splanchnic organs from oxidative stress induced by pneumoperitoneum

Mesna protects splanchnic organs from oxidative stress induced by pneumoperitoneum

Prevention of renal ischemia/reperfusion‐induced injury in rats by leflunomide

Evaluation of turbidimetric and nephelometric techniques for analytical determination of n-acetylcysteine and thiamine in pharmaceutical formulations employing a lab-made portable microcontrolled turbidimeter and nephelometer

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