Mesigyna® once-a-month combined injectable contraceptive: Experience in Latin America

Comparative Performance of a Combined Injectable Contraceptive (50 mg Norethisterone Enanthate Plus 5mg Estradiol Valerate) and a Combined Oral Contraceptive (0.15 mg Levonorgestrel plus 0.03 mg Ethinyl Estradiol) in Adolescents

“…17 The incidence of dysmenorrhea, in two different studies with monthly combined injectable of 50 mg noresthisterone enanthate, was 6.5% and 9.83 % respectively at month 12. 18,19 In our study, the incidence of dysmenorrhea reached 41% among IC users and 14% among OC users at month 12. This study showed a higher incidence of breast tenderness (12% and 14%) at months 6 and 12 than the one reported by other investigators (1.1 % and 4%) for the same periods of observation.…”

“…Loss to follow up (39.5% and 44.9% for IC and OC users), was higher in comparison with the adult studies, but similar to adolescent studies where the proportion was 38.4%. 17,18,21 This finding was expected, due to the well-known behavior of adolescents regarding contraceptive use, especially of those who are preventing the first pregnancy.…”

“…This study showed a higher incidence of breast tenderness (12% and 14%) at months 6 and 12 than the one reported by other investigators (1.1 % and 4%) for the same periods of observation. 18 The proportion of dysmenorrhea and breast tenderness is higher in this study, because both mild and severe cases were considered.…”

“…In the Colombian and Latin American adult studies of monthly combined injectable of 50 mg noresthisterone enanthate discontinuation rates were lower: 45.1 % and 17.9% at the end of the first year respectively, varying from 9.7% to 49.5% among the six participating countries in the last study. 17,18 In the study of 73 adolescents IC users the discontinuation rate was 48% at one year. 21 In IC and OC groups, reasons for discontinuation were similar to other studies with adult IC.…”

Estradiol valerate and alcohol intake: dose-response assessments

“…The long half-life of EV indicates that with multiple doses of EV, there could be an accumulation of estradiol. Two mg doses of EV along with a progesterone-like drug, given monthly, are the doses used in birth control drugs touted as effective for use by women of underdeveloped countries with special reference to Latin America [32]. …”