Mesial temporal lobe epilepsy diminishes functional connectivity during emotion perception

Steiger, Bettina K.; Müller, Angela; Spirig, Esther; Toller, Gianina; Jokeit, Hennric

doi:10.1016/j.eplepsyres.2017.05.004

Cited by 24 publications

(10 citation statements)

References 41 publications

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“…Similar to our findings, Toller et al demonstrated by dynamic fearful faces fMRI that right mTLE was associated with reduced activity in the right amygdala, suggesting its mediating role in the emotional awareness of empathic experiences of fear (50). In patients with mTLE, the deficits in facial emotion perception are contributed to the disruptions of functional networks, which are more pronounced in right mTLE (51). Children and adolescents with mTLE also demonstrate deficits in perception of different emotions, especially of fear (52).…”

Section: Discussionsupporting

confidence: 91%

Emotional Recognition in Patients With Mesial Temporal Epilepsy Associated With Enlarged Amygdala

et al. 2022

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Background:Amygdalae play a central role in emotional processing by interconnecting frontal cortex and other brain structures. Unilateral amygdala enlargement (AE) is associated with mesial temporal lobe epilepsy (mTLE). In a relatively large sample of patients with mTLE and AE, we aimed to evaluate functional integration of AE in emotion processing and to determine possible associations between fMRI activation patterns in amygdala and deficits in emotion recognition as assessed by neuropsychological testing.Methods:Twenty-two patients with drug resistant unilateral mTLE due to ipsilateral AE were prospectively recruited in a large epilepsy unit and compared with 17 healthy control subjects in terms of amygdala volume, fMRI activation patterns and performance in emotion recognition as assessed by comprehensive affect testing system (CATS) and Ekman faces. All patients underwent structural and functional 1.5 Tesla MRI, electro-clinical assessment and neuropsychological testing.Results:We observed BOLD signal ipsilateral to AE (n = 7; group PAT1); contralateral to AE (n = 6; group PAT2) and no activation (n = 9; group PAT3). In the region of interest (ROI) analysis, beta estimates for fearful face > landscape contrast in the left amygdala region did not differ significantly in patients with left TLE vs. patients with right TLE [T(16) = −1.481; p = 0.158]. However, beta estimates for fearful face > landscape contrast in the right amygdala region were significantly reduced in patients with right TLE vs. patients with left TLE [T(16) = −2,922; p = 0.010]. Patients showed significantly lower total scores in CATS and Ekman faces compared to healthy controls.Conclusion:In our cohort, patients with unilateral mesial TLE and ipsilateral AE, an amygdala could display either functional integration in emotion recognition or dysfunction as demonstrated by fMRI. Perception and recognition of emotions were impaired more in right-sided mTLE as compared to left-sided mTLE. Neuropsychological tests showed deficits in emotion recognition in patients as compared to healthy controls.

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Section: Discussionsupporting

confidence: 91%

Emotional Recognition in Patients With Mesial Temporal Epilepsy Associated With Enlarged Amygdala

et al. 2022

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“…To further interrogate these findings, a seed-based functional connectivity analysis was conducted to assess connectivity between the brain regions activated during the viewing of the fearful face paradigm (26). Widespread bilateral functional connectivity was observed between the amygdala, limbic, cortical, subcortical, and brainstem regions in HC.…”

Section: Resultsmentioning

confidence: 99%

“…Results of functional connectivity analysis within the network of activated regions in response to the dynamic task were replicated in two separate studies. Widespread bilateral connectivity was observed between the amygdala, limbic, cortical, subcortical, and brainstem regions in HC in both seed-based analysis (26) and ICA (20). A smaller network of connectivity was noted in patients with left MTLE and no significant functional connectivity was evident in patients with right MTLE.…”

Section: Discussionmentioning

confidence: 99%

“…A smaller network of connectivity was noted in patients with left MTLE and no significant functional connectivity was evident in patients with right MTLE. Comparable connectivity patterns in the extra-TLE group to those in HC further suggest that altered patterns of connectivity could not be attributed to seizure activity or AED treatment (26). Similarly, amygdala co-activation with temporal and frontal regions was significantly reduced in patients with right MTLE in ICA (20).…”

Section: Discussionmentioning

confidence: 99%

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Impaired Social Cognition in Epilepsy: A Review of What We Have Learnt From Neuroimaging Studies

Ives‐Deliperi

Jokeit

2019

Front. Neurol.

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Background: Social cognition refers to specific mental processes that subserve social interaction. Impaired social cognition has been increasingly reported in patients with epilepsy and negatively affects overall quality of life (QOL). In this article, we will review neuroimaging studies of social cognition in people with epilepsy.Methods: An electronic search of the literature was conducted and 14 studies qualified for inclusion in the review.Results: Although the studies reviewed revealed a varied pattern of neural activations in response to emotion recognition and theory of mind tasks, consensual findings included altered pattern of signal activation in the social cognition network in patients with mesial temporal lobe epilepsy (MTLE) compared to healthy controls and significantly reduced signal activations and functional connectivity within this network in patients with right mesial temporal lobe pathology.Conclusion: This review contextualizes our current understanding of the pathophysiology of impaired social cognition in epilepsy and makes recommendations for further research.

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“…However, the integrity of these circuits is compromised in adults with epilepsy. Functional connectivity between the above regions when viewing fearful faces was reduced in adults with mesial TLE compared with healthy controls [47]. In addition, patients with amygdala atrophy from MTS [48] or from conditions like frontotemporal dementia [49] demonstrated blunted response to fearful faces in face-processing regions compared with control groups.…”

Section: Blunted Neural Response To Emotional Faces In Youth With Epilepsymentioning

confidence: 91%

Blunted neural response to emotional faces in the fusiform and superior temporal gyrus may be marker of emotion recognition deficits in pediatric epilepsy

Morningstar

Hung

Grannis

et al. 2020

Epilepsy & Behavior

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Mesial temporal lobe epilepsy diminishes functional connectivity during emotion perception

Cited by 24 publications

References 41 publications

Emotional Recognition in Patients With Mesial Temporal Epilepsy Associated With Enlarged Amygdala

Emotional Recognition in Patients With Mesial Temporal Epilepsy Associated With Enlarged Amygdala

Impaired Social Cognition in Epilepsy: A Review of What We Have Learnt From Neuroimaging Studies

Blunted neural response to emotional faces in the fusiform and superior temporal gyrus may be marker of emotion recognition deficits in pediatric epilepsy

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