Mesh pullout force: comparative study of different deployment techniques in a sheep model

Alcalay, M.; Livneh, Miron; Braun, Nicole; Tov, Yariv Siman; Hod, Eitan

doi:10.1007/s00192-013-2162-3

Cited by 10 publications

(2 citation statements)

References 14 publications

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“…Collagen I, II and inflammatory infiltrate levels were analysed at implant site 7, 30 and 90 Coating PP mesh with platelet-rich plasma enhanced tissue regeneration with higher total collagen concentration Promising results; however, it is unclear if these histology outcomes will result in better clinical outcomes Brazil Avila et al [ 34 ] Mesh B: mesh A coated with platelet-rich plasma extracted from blood via centrifuge Rabbit Mesh A: PP mesh Abdominal wall Meshes C and D were compared as alternative materials to commercially available Meshes A and B. Implants were placed in full-thickness abdominal wall defects 30 and 90 Meshes C and D had better outcomes, with decreased inflammatory response Promising results regarding alternative materials; however, these would need replication in larger animal models Belgium and UK Sabiniano et al [ 35 ] Mesh B: PVDF mesh Mesh C: polyurethane mesh Mesh D: poly-L-lactic acid Sheep EndoFast Reliant™ System Thigh fascia EndoFast Reliant™ System was used to insert mesh into sheep thigh fascia. Pullout force was measured at each endpoint 0, 3, 7, 15, 30 and 45 Test to investigate the strength of attachment; results showed that the experimental system provided much stronger mesh attachment than trocar-based methods Sheep thigh was used as the site of implantation owing to histological similarity, rather than vagina tissue Israel Alcalay et al [ 36 ] Only papers written in English language were included in the table eMSCs endometrial mesenchymal stem cells, ME mesh exposure, NHP non-human primate, NZW New Zealand White, PCL poly ε-caprolactone, PCU polycarbonate urethane, PDMS polydimethylsiloxane, POP pelvic organ prolapse, PP polypropylene, PVDF polyvinylidene fluoride, SD Sprague–Dawley …”

Section: Resultsmentioning

confidence: 99%

The use of animal models in preclinical investigations for the development of a surgical mesh for pelvic organ prolapse

Seifalian,

Digesu,

Khullar

2024

Int Urogynecol J

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Introduction and hypothesis Polypropylene (PP) mesh for the treatment of pelvic organ prolapse (POP) has raised substantial concerns over long-term complications, leading to its ban in multiple countries. In response, emerging materials are being explored as alternatives for prolapse surgery. Preclinical animal models have historically played a pivotal role in validating medical devices, prior to clinical trials. Successful translation of these materials necessitates the identification of suitable animal models that replicate the female human pelvis and its biomechanical properties. Preclinical in vivo testing assesses the safety of surgical mesh and treatment efficacy in preventing POP recurrence. Methods The research critically reviews animal models used for preclinical pelvic mesh testing over the last decade and proposes a promising model for future preclinical studies. Results Rats were the most common mammal used for toxicity and biocompatibility investigations through abdominal implantation. Although non-human primates serve as a gold standard for efficacy testing, ethical considerations limit their use owing to their close biological and cognitive resemblance to humans. Consequently, sheep were the most preferred large animal model owing to their reproductive system similarities and propensity for spontaneous POP following parity. Conclusion The study contributes valuable insights into the selection of appropriate animal models for preclinical pelvic mesh testing, offering guidance that is crucial for enhancing the safety and efficacy of novel surgical interventions in the treatment of POP.

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Section: Resultsmentioning

confidence: 99%

The use of animal models in preclinical investigations for the development of a surgical mesh for pelvic organ prolapse

Seifalian,

Digesu,

Khullar

2024

Int Urogynecol J

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“…Briefly, the 3 mm thick needle passer funneled through the abdominal wall tissue forces the 2 cm wide strap to roll along the axis. This principle of physics, already recognized in the literature, appears to be an appropriate way to ensure a fixation-free, but firm placement, of the polypropylene bands used for the treatment of female genital prolapse [ 25 , 26 , 27 , 28 , 29 ]. Therefore, the friction of the rolled strap surface in the narrow passageway allows for a stable placement amid the tissues crossed.…”

Section: Discussionmentioning

confidence: 99%

Tentacle Mesh for Fixation-Free Spigelian Hernia Repair: Mini-Invasive Approach Granting Broad Defect Overlap

Amato

Agrusa

Buscemi

et al. 2023

JCM

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Background: Compared to other types of abdominal protrusions, Spigelian hernias are not very common. In prosthetic repair of abdominal protrusions, mesh fixation and defect overlap are an open issue, as they are a source of complications. A newly developed tentacle-shaped mesh has been used to ensure a fixation-free repair with a broader defect overlap in the repair of abdominal hernias. This study describes the long-term results of a fixation-free repair of Spigelian hernias carried out with a tentacle mesh. Methods: A proprietary mesh composed of a central body with integrated radiating arms was used for repairing Spigelian hernias in 54 patients. The implant was positioned in preperitoneal sublay, and the straps were delivered across the abdominal musculature with a needle passer, and then, after fascia closure, cut short in the subcutaneous layer. Results: The friction of the straps passing through the abdominal wall served to hold the mesh in place, guaranteeing a wide overlap over the defect without fixation. In a long-term follow-up of 6 to 84 months (mean 64 months), a very low rate of complications occurred, but no recurrence was reported. Conclusions: The tentacle strap system of the prosthesis allowed for an easy, fast and safe fixation-free placement granting a wide overlap, avoiding intraoperative complications. Greatly reduced pain and a negligible amount of postoperative complications characterized the postoperative outcome.

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Influence of TVT properties on outcomes of midurethral sling procedures: high-stiffness versus low-stiffness tape

Prien-Larsen

Cieslak

et al. 2016

Int Urogynecol J

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Mesh pullout force: comparative study of different deployment techniques in a sheep model

Abstract: The EndoFast Reliant system provides significantly stronger attachment in the immediate postoperative period (0-3 days) compared with trocar-based techniques, and this difference disappeared at day 15 postsurgery.

Cited by 10 publications

References 14 publications

The use of animal models in preclinical investigations for the development of a surgical mesh for pelvic organ prolapse

The use of animal models in preclinical investigations for the development of a surgical mesh for pelvic organ prolapse

Tentacle Mesh for Fixation-Free Spigelian Hernia Repair: Mini-Invasive Approach Granting Broad Defect Overlap

Influence of TVT properties on outcomes of midurethral sling procedures: high-stiffness versus low-stiffness tape

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