Mesh-based method for measuring intracranial volume in patients with craniosynostosis

Ritvanen, Antti; Oliveira, Marcelo Elias de; Koivikko, Mika P.; Hallila, Harri; Haaja, Juha; Koljonen, Virve; Leikola, Junnu; Hukki, Jyri; Paulasto‐Kröckel, Mervi

doi:10.1007/s11548-013-0822-x

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…Verification of the segmented volume against the original slice data sets ensures proper registration of the ICV. This work flow is admittedly too complicated and unnecessarily exact for clinical use, but automated segmentation algorithms have shown excellent results [15]. Volume estimates and indices from simple three-plane measurements do not reliably reflect the ICV and are, in our experience, obsolete [16].…”

Section: Siv Measurementmentioning

confidence: 95%

Length of synostosis and segmented intracranial volume correlate with age in patients with non-syndromic sagittal synostosis

et al. 2017

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Section: Siv Measurementmentioning

confidence: 95%

Length of synostosis and segmented intracranial volume correlate with age in patients with non-syndromic sagittal synostosis

et al. 2017

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“…The ICV measure, sometimes referred to as total intracranial volume (TIV), refers to the estimated volume of the cranial cavity as outlined by the supratentorial dura matter or cerebral contour when dura is not clearly detectable [ 7 ]. ICV is often used in studies involved with analysis of the cerebral structure under different imaging modalities, such as Magnetic Resonance (MR) [ 8 , 9 ], MR and Diffusion Tensor Imaging (DTI) [ 10 ], MR and Single-photon Emission Computed Tomography (SPECT) [ 11 ], Ultrasound [ 12 ] and Computed Tomography (CT) [ 13 , 14 ]. ICV consistency during aging [ 15 ] makes it a reliable tool for correction of head size variation across subjects in studies that rely on morphological features of the brain.…”

Section: Introductionmentioning

confidence: 99%

A practical guideline for intracranial volume estimation in patients with Alzheimer's disease

Sargolzaei

Cabrerizo

et al. 2015

BMC Bioinformatics

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BackgroundIntracranial volume (ICV) is an important normalization measure used in morphometric analyses to correct for head size in studies of Alzheimer Disease (AD). Inaccurate ICV estimation could introduce bias in the outcome. The current study provides a decision aid in defining protocols for ICV estimation in patients with Alzheimer disease in terms of sampling frequencies that can be optimally used on the volumetric MRI data, and the type of software most suitable for use in estimating the ICV measure.MethodsTwo groups of 22 subjects are considered, including adult controls (AC) and patients with Alzheimer Disease (AD). Reference measurements were calculated for each subject by manually tracing intracranial cavity by the means of visual inspection. The reliability of reference measurements were assured through intra- and inter- variation analyses. Three publicly well-known software packages (Freesurfer, FSL, and SPM) were examined in their ability to automatically estimate ICV across the groups.ResultsAnalysis of the results supported the significant effect of estimation method, gender, cognitive condition of the subject and the interaction among method and cognitive condition factors in the measured ICV. Results on sub-sampling studies with a 95% confidence showed that in order to keep the accuracy of the interleaved slice sampling protocol above 99%, the sampling period cannot exceed 20 millimeters for AC and 15 millimeters for AD. Freesurfer showed promising estimates for both adult groups. However SPM showed more consistency in its ICV estimation over the different phases of the study.ConclusionsThis study emphasized the importance in selecting the appropriate protocol, the choice of the sampling period in the manual estimation of ICV and selection of suitable software for the automated estimation of ICV. The current study serves as an initial framework for establishing an appropriate protocol in both manual and automatic ICV estimations with different subject populations.

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“…25 In Figure 7 Independent mineralization area separate from the bone margins. A 1-week postoperative image of DBM defect of patient number 3. comparison, Leikola et al used threshold limit from À90 to 155 HU for segmentation of pediatric brain tissue.…”

Section: Discussionmentioning

confidence: 99%

Promoting ossification of calvarial defects in craniosynostosis surgery by demineralized bone plate and bone dust in different age groups

Savolainen

Ritvanen

Hukki

et al. 2017

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Summary Correction of calvarial defects after calvarial vault reconstruction (CVR) is challenging in craniosynostosis patients of advanced age and typically employs autologous bone. Demineralized bone matrix (DBM) is a potential alternative material for autologous bone, but its use has not been extended to correct calvarial defects.CVR patients operated at the Department of Plastic Surgery, Helsinki University Hospital, during 2008e2010 were retrospectively reviewed. Inclusion criteria of the study were CVR patients who received DBM plate, with or without bone dust, on calvarial defects and who had suitable uncovered defect on the contralateral side as control. This study included 17 craniosynostosis and one positional plagiocephaly patient, whose mean age was 6.9 years (range 0.9e19 years). The mean follow-up time was 5.6 years. The fusion degree of all defects was measured from 1 week to 1 year postoperatively using three-dimensional computed tomography (3D CT) images by the OsiriX ª method. Medical records were reviewed for DBM-related complications.A total of 26 defects were covered with a DBM plate (mean area 11.1 cm 2 ) and 26 control defects were identified (mean area 7.8 cm 2 ). The mean fusion degree of the DBM defects was 74%and 54% for the controls (p < 0.001). The mean fusion degree of nine DBM defects that lacked bone dust deposition was 66% and 55% for the nine controls (p < 0.059). The difference between the DBM and control defects was statistically significant for patients older than 30 months (p < 0.03). No DBM-related complication was observed.

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Mesh-based method for measuring intracranial volume in patients with craniosynostosis

Cited by 8 publications

References 19 publications

Length of synostosis and segmented intracranial volume correlate with age in patients with non-syndromic sagittal synostosis

Length of synostosis and segmented intracranial volume correlate with age in patients with non-syndromic sagittal synostosis

A practical guideline for intracranial volume estimation in patients with Alzheimer's disease

Promoting ossification of calvarial defects in craniosynostosis surgery by demineralized bone plate and bone dust in different age groups

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