Mesenteric Vessel Patency Following HIFU Therapy in Patients with Locally Invasive Pancreatic Cancer

Strunk, H.; Lützow, C; Henseler, J; Mücke, Martin; Rauch, Maximilian; Marx, Christian; Schild, Hans H.; Marinova, Milka

doi:10.1055/s-0043-125391

Cited by 19 publications

(18 citation statements)

References 32 publications

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“…There were no shape changes of blood vessels, as well as no vascular adverse events, such as vascular occlusion, thrombosis and rupture of blood vessels. These results corroborated previous studies (16,35).…”

Section: Discussionsupporting

confidence: 93%

“…Compared with venous vessels, arterial vessels have lower probability of thrombosis and partial narrowing of blood vessels is more likely to occur. This is consistent with findings from Strunk et al (16). In addition, physicians should be aware of the tumor squeezing blood vessels or tumor invasion of blood vessels during the HIFU therapy.…”

Section: 12supporting

confidence: 91%

“…It was first reported in 2000 that HIFU successfully ablates and treats pancreatic cancer (29). Several studies have confirmed the safety and efficacy of HIFU in the treatment of pancreatic cancer (10,(14)(15)(16)(19)(20)(21)(22)(23)(24)(25)(29)(30)(31)(32)(33)(34). The most common complications observed following HIFU treatment of pancreatic cancer include skin burns (10,15,17,(21)(22)(23)(30)(31)(32), pancreatitis (10,18,23,31,32), duodenal fistula (23,31) and obstructive jaundice (19,34).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, HIFU ablation of pancreatic cancer is safe for peripancreatic blood vessels. Strunk et al (16) reported that 94% of patients showed no patency change in associated vessels after HIFU treatment of locally pancreatic cancer with tumor invasion and encasement of blood vessels. Meanwhile, no vascular adverse events were recorded.…”

Section: Discussionmentioning

confidence: 99%

“…widely used in the treatment of uterine fibroids and hepatocellular carcinoma, with good therapeutic results (12). Previous studies have confirmed that HIFU therapy effectively alleviates cancer-associated abdominal pain, reduces tumor volume and may confer an additional survival benefit (11,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). However, vascular complications caused by this treatment have been reported, including secondary occlusion of the superior mesenteric artery (24) and portal vein thrombosis (25).…”

Section: Effects Of High-intensity Focused Ultrasound Treatment On Pementioning

confidence: 99%

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Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer

et al. 2020

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The present study aimed to evaluate the safety of high-intensity focused ultrasound (HIFU) treatment on peripancreatic arterial and venous blood vessels in patients with pancreatic cancer. This trial included 15 patients with pancreatic cancer (9 females and 6 males; age, 39-81 years; median age, 62 years). All patients underwent preoperative computed tomography (CT) or magnetic resonance imaging (MRI) and color Doppler flow imaging (CDFI) to assess the vascular hemodynamics of peripancreatic arterial and venous blood vessels pre-treatment. These patients were re-examined within 1 week post-HIFU treatment. Then, vascular adverse events were observed and followed up clinically. Prior to HIFU treatment, vessel involvement was recorded in 13 patients, including tumor lesions invading 19 veins and 14 arteries, which refers to the growth of pancreatic tumor lesions surrounding blood vessels, or tumor growth into blood vessels. In addition, 9 veins and 13 arteries were <1 cm from the lesions. The hemodynamic parameters of peripancreatic vessels were measured using CDFI, including mean blood flow velocity, peak systolic blood flow velocity, vascular resistance index, vascular pulsatility index, vascular diameter, vascular blood flow and other indicators, to assess vascular perfusion in CT/MRI. There were no significant differences in preoperative and postoperative hemodynamic data (P>0.05). Overall, HIFU demonstrated no negative effects on peripancreatic arterial and venous blood vessels in patients with pancreatic cancer, even with tumor lesions wrapped in blood vessels. In addition, no complications of vascular stenosis and vascular adverse events were observed in the present study.

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Section: Discussionsupporting

confidence: 93%

Section: 12supporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Effects Of High-intensity Focused Ultrasound Treatment On Pementioning

confidence: 99%

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Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer

et al. 2020

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High-intensity focused ultrasound therapy for pancreatic cancer

et al. 2022

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Pancreatic cancer (PC) has one of the poorest prognoses among solid cancers, and its incidence has increased recently. Satisfactory outcomes are not achieved with current therapies; thus, novel treatments are urgently needed. High-intensity focused ultrasound (HIFU) is a novel therapy for ablating tissue from the outside of the body by focusing ultrasonic waves from multiple sources on the tumor. In this therapy, only the focal area is heated to 80–100 ºC, which causes coagulative necrosis of the tissue, with hardly any impact on the tissue outside the focal area. Although HIFU is a minimally invasive treatment and is expected to be useful, it is not yet generally known. Here, we discuss the usefulness of HIFU treatment for un-resectable advanced PC using the results of previous research, meta-analyses, and systematic reviews on its efficacy and safety. HIFU therapy for un-resectable PC is useful for its anti-tumor effect and pain relief, and is expected to prolong survival time and improve quality of life. Although HIFU for PC has several limitations and further study is needed, this technique can be safely performed on un-resectable advanced PC. In future, HIFU could be utilized as a minimally invasive treatment strategy for PC patients with a poor prognosis.

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High Intensity Focused Ultrasound (HIFU) in Digestive Diseases: An Overview of Clinical Applications for Liver and Pancreatic Tumors

Dupré¹,

Melodelima²,

Cilleros³

et al. 2023

IRBM

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Mesenteric Vessel Patency Following HIFU Therapy in Patients with Locally Invasive Pancreatic Cancer

Abstract: This study demonstrates that HIFU treatment can be safely applied to pancreatic cancers enveloping large mesenteric vessels despite vessel narrowing or extensive collateral propagation. Most patients (94 %) did not experience adverse effects regarding vessel patency.

Cited by 19 publications

References 32 publications

Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer

Effects of high‑intensity focused ultrasound treatment on peripancreatic arterial and venous blood vessels in pancreatic cancer

High-intensity focused ultrasound therapy for pancreatic cancer

High Intensity Focused Ultrasound (HIFU) in Digestive Diseases: An Overview of Clinical Applications for Liver and Pancreatic Tumors

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