Mesenteric vein thrombosis in a pregnant patient heterozygous for the factor V (1691 G → A) Leiden mutation

Sönmezer, Murat; Aytaç, Ruşen; Demirel, L.C.; Kurtay, Gülay

doi:10.1016/j.ejogrb.2003.09.014

Cited by 10 publications

(13 citation statements)

References 7 publications

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“…Management can be conservative with anticoagulation, control of the clinical course and repeated ultrasound scans under absence of ischemia [4]. The literature describes 3 cases of pregnant patients with MVT without mesenteric ischemia managed conservatively [7,9,10]. In all three cases, the pregnancy comes to term.…”

Section: Discussionmentioning

confidence: 99%

“…However, as far as we know, the combination of antithrombin deficiency, MVT and pregnancy has never been described and only two cases of MVT related to thrombophilia during pregnancy have been described in the literature. The first case involves a patient carrying the factor V Leiden polymorphism in heterozygous state who was handled conservatively with anticoagulation leading to success [7]. The second case was a patient with protein S deficiency who also required from surgical intervention with resection of a large segment of small intestine due to the mesenteric ischemia.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

First case with antithrombin deficiency, mesenteric vein thrombosis and pregnancy: Multidisciplinary diagnosis and successful management

García‐Botella

Asenjo

Morena‐Barrio

et al. 2016

Thrombosis Research

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

First case with antithrombin deficiency, mesenteric vein thrombosis and pregnancy: Multidisciplinary diagnosis and successful management

García‐Botella

Asenjo

Morena‐Barrio

et al. 2016

Thrombosis Research

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“…MVT due to FV Leiden mutation has been reported in recent studies, while the first case in pregnancy was demonstrated by Sönmezer et al . (2004) [17]. At least one of the above factors presents in most cases with MVT, while idiopathic MVT ranges from 21 to 49% among the different series [15].…”

Section: Discussionmentioning

confidence: 99%

“…The early diagnosis of MVT, which is a potentially life-threatening condition, is very important to prevent high mortality and morbidity [17]. Non-characteristic signs and symptoms in pregnancy are the common problems leading to late diagnosis and treatment of acute abdominal pain.…”

Section: Discussionmentioning

confidence: 99%

Mesenteric cysts and mesenteric venous thrombosis leading to intestinal necrosis in pregnancy managed with laparotomy: a case report and review of the literature

et al. 2017

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BackgroundMesenteric cyst is a rare clinical entity especially in pregnancy; therefore, few cases have been reported in the literature. The standard method of their treatment is surgical excision either with laparotomy or laparoscopy. In addition, mesenteric vein thrombosis is a rare and life-threatening condition in pregnancy and needs immediate treatment because it can lead to intestinal necrotic ischemia. This is the first report of the coexistence of mesenteric cysts and mesenteric vein thrombosis during gestation.Case presentationA 27-year-old Greek woman, gravida 2 para 1, presented at 10 weeks’ gestation to the Emergency Unit of our hospital complaining of diffuse abdominal pain which deteriorated the last 3 days, which was localized in her right iliac fossa, along with vomiting. She had undergone open laparotomy and right salpingo-oophorectomy at the age of 23 due to an ovarian cyst. Besides this, her personal and family medical history was unremarkable. She had never received oral contraceptives or any hormone therapy. On arrival, a clinical examination revealed tenderness on palpation of her right iliac fossa, without rebound tenderness or muscle guarding. Within 10 hours of hospitalization, her symptoms deteriorated further with rebound tenderness during the examination, tachycardia, and a drop of 12 units in her hematocrit value. An emergency laparotomy was performed. Two mesenteric cysts and a 60 cm necrotic part of her intestine were revealed intraoperatively. In the postoperative period, she complained of acute abdominal pain, tachycardia, and dyspnea. Computed tomography imaging revealed mesenteric vein thrombosis and pulmonary thromboembolism. She was treated with low molecular weight heparin and she was discharged on the 11th postoperative day.ConclusionsTo the best of our knowledge, this is the first report in the literature of a simultaneous mesenteric cyst and mesenteric vein thrombosis in pregnancy. It is known that pregnancy is a state of hypercoagulation and clinicians should bear in mind this rare clinical condition in their diagnostic algorithm for acute abdominal pain.

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“…Bei Patienten, die von solchen sog. primären Mesenterialvenenthrombosen betroffen sind, lassen sich durch entsprechende Diagnostik häufig genetisch determinierte thrombophile Risikofaktoren nachweisen [1 -3, 10,18,29]. Von den bekannten thrombophilen Prädispositionen ist die Faktor-V-Leiden-Mutation, die zu einer Resistenz des Faktors V gegen die Inaktivierung durch aktiviertes Protein C (APC-Resistenz) führt, die häu-figste.…”

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Akuter hämorrhagischer Jejunuminfarkt als Erstmanifestation einer APC-Resistenz bei Faktor-V-Leiden-Mutation - ein Fallbericht

Garlipp¹,

Gerhardt²,

Linke³

et al. 2008

Z Gastroenterol

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We report on a 43-year-old patient presenting to the emergency department with acute abdominal pain the source of which turned out to be acute hemorrhagic jejunal infarction due to portal and mesenteric vein occlusion with no apparent cause. In spite of a lacking history of hereditary thrombophilic risk factors, further diagnostic procedures revealed heterozygous factor V Leiden mutation. Diagnosis, therapy and clinical course are described. An overview on acute mesenteric venous occlusion with special reference to genetically determined thrombophilic disorders is given.

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Mesenteric vein thrombosis in a pregnant patient heterozygous for the factor V (1691 G → A) Leiden mutation

Cited by 10 publications

References 7 publications

First case with antithrombin deficiency, mesenteric vein thrombosis and pregnancy: Multidisciplinary diagnosis and successful management

First case with antithrombin deficiency, mesenteric vein thrombosis and pregnancy: Multidisciplinary diagnosis and successful management

Mesenteric cysts and mesenteric venous thrombosis leading to intestinal necrosis in pregnancy managed with laparotomy: a case report and review of the literature

Akuter hämorrhagischer Jejunuminfarkt als Erstmanifestation einer APC-Resistenz bei Faktor-V-Leiden-Mutation - ein Fallbericht

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