“…A fall in systemic arterial pressure in our experiments following the infusion of synthetic chicken VIP was largely consistent with previously reported actions of porcine VIP (Said and Mutt, 1970 a and b ;Bodanszky et al, 973;Thulin, 1973;Kachelhoffer et al, 1974 ;Kitamura et al, 1975). An increase in pancreatic blood flow was also observed following its injection.…”
SynopsisThe effects of synthetic chicken VIP (an octacosapeptide corresponding to the entire sequence of chicken VIP) on pancreatic blood flow and on systemic arterial pressure was examined in dogs. The relationship between pancreatic blood flow and systemic arterial pressure in response to synthetic chicken VIP was also investigated. Pancreatic blood flow increased promptly and significantly with exogenous synthetic chicken VIP. Synthetic chicken VIP administered in graded doses resulted in dose-dependent increases in both the peak rate of the pancreatic blood flow and the duration of the response of the pancreatic blood flow. Graded doses of synthetic chicken VIP also elicited both a graded increase in the systemic systolic pressure and a decrease in the systemic diastolic pressure.Therefore, synthetic chicken VIP given in graded doses resulted in a dose-dependent augmentation of the maximum pulse pressure.Pancreatic blood flow increased despite a fall in the systemic arterial pressure in response to synthetic chicken VIP. This increase in blood flow lasted significantly longer than the changes in the systemic arterial pressure.It was clarified in this study that synthetic chicken VIP has a biological effect on both the pancreatic blood flow and the systemic arterial pressure.The results of our experiments also suggest that synthetic chicken VIP itself may directly induce vasodilatation of the local vessels in the pancreas.
“…A fall in systemic arterial pressure in our experiments following the infusion of synthetic chicken VIP was largely consistent with previously reported actions of porcine VIP (Said and Mutt, 1970 a and b ;Bodanszky et al, 973;Thulin, 1973;Kachelhoffer et al, 1974 ;Kitamura et al, 1975). An increase in pancreatic blood flow was also observed following its injection.…”
SynopsisThe effects of synthetic chicken VIP (an octacosapeptide corresponding to the entire sequence of chicken VIP) on pancreatic blood flow and on systemic arterial pressure was examined in dogs. The relationship between pancreatic blood flow and systemic arterial pressure in response to synthetic chicken VIP was also investigated. Pancreatic blood flow increased promptly and significantly with exogenous synthetic chicken VIP. Synthetic chicken VIP administered in graded doses resulted in dose-dependent increases in both the peak rate of the pancreatic blood flow and the duration of the response of the pancreatic blood flow. Graded doses of synthetic chicken VIP also elicited both a graded increase in the systemic systolic pressure and a decrease in the systemic diastolic pressure.Therefore, synthetic chicken VIP given in graded doses resulted in a dose-dependent augmentation of the maximum pulse pressure.Pancreatic blood flow increased despite a fall in the systemic arterial pressure in response to synthetic chicken VIP. This increase in blood flow lasted significantly longer than the changes in the systemic arterial pressure.It was clarified in this study that synthetic chicken VIP has a biological effect on both the pancreatic blood flow and the systemic arterial pressure.The results of our experiments also suggest that synthetic chicken VIP itself may directly induce vasodilatation of the local vessels in the pancreas.
“…The temporary vasodilator effect of VIP on the SMA vascu lar bed corresponds to the earlier results of Kachelhoffer et al [13], but it is not sup ported by the findings of Thulin and Olsson [12] and Mailman [14], using similar dose ranges of the peptide. However, these data are difficult to interpret as bolus doses [11] or 1 min infusions [12,13] rather than sus tained infusions of VIP were administered.…”
Section: Discussionsupporting
confidence: 64%
“…The results of infusions of pharmacologi cal doses of VIP (doses resulting in higher than 1,000 pmol/1 plasma concentrations in the investigated vascular beds) suggest that VIP has a positive inotropic and chrono tropic effect on the heart, is a systemic vaso dilator and exerts a differential vasodilator effect on different vascular beds [10,11], However, its action on the splanchnic vascu lar bed is not fully understood and both vasodilator and vasoconstrictor roles for VIP on the mesenteric circulation have been proposed when smaller 'physiologic' doses were employed [12][13][14], The diversity of ani mal models and species differences make a simple summary of the circulatory effects of VIP difficult.…”
Vaso-active intestinal polypeptide (VIP) and the related peptide, peptide histidine isoleucine, were infused intravenously in anaesthetized sheep. The VIP doses were designed to reproduce plasma concentrations seen after mesenteric ischaemia. The vasodilator action of VIP varied between different segments of the circulation and these differences in sensitivity were observed for both the degree and duration of the vaso-active action. A sustained vasodilation was detected in the coeliac artery and portal vein vascular beds during a 30-min VIP infusion. VIP is likely to be a contributory factor involved in the development of circulatory collapse during reperfusion after experimental mesenteric ischaemia.
“…The surgical procedure and the perfusion technique have been extensively described in previous reports [10,11], For motility determination and for distension of the gut, silicone rubber tubings were inserted into the lumen at both ends of the intestinal segments and tied with umbilical tape. One of the lumi nal catheters was connected to a fluid reservoir which could be set at any chosen height above the organ level, and to a pressure transducer (Statham SB 25).…”
The effects of spontaneous intestinal motor activity and artificial luminal distension on mesenteric hemodynamics were studied on isolated canine jejunal loops perfused at normothermia under pulsatile flow with heparinized and oxygenated dogs whole blood. To each increase in intestinal tonic activity or intraluminal distension there is a corresponding linear increase in arterial pressure (under constant flow). The hemodynamic effect of distension is less potent than that produced by spontaneous motility. In the luminal pressure range explored (<25 mm Hg) distension does not modify the intestinal O2 consumption. Spontaneous rhythmic contractions produce oscillations of the venous outflow of the same periodicity as the phasic activity of the bowel and having a magnitude proportional to the strength of the contractions. These results show that intestinal motility or gut lumen distension affects mesenteric hemodynamics by increasing the resistance to blood flow. The linearity of the responses and the absence of any readjustment of the vascular resistance during either tonic contraction or distension seem to indicate a vascular effect resulting only from a mechanical compressing action on the blood vessels. No drastic and irreversible hemodynamic and functional impairments, however, could be observed when the intraluminal pressures involved remain moderate ( < 25 mm Hg). On the other hand the periodic fluctuations of the venous outflow produced by the rhythmic activity may contribute to the mixing and to the propulsion of the mesenteric blood to the portal circulation.
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