Mesenteric phlebosclerosis associated with long‐term oral intake of geniposide, an ingredient of herbal medicine

Hiramatsu, Katsushi; Sakata, Hidenao; Horita, Yuki; Orita, Noriaki; Kida, Akihiko; Mizukami, Atsuyoshi; Miyazawa, Masaki; Hirai, Satoshi; Shimatani, Akiyoshi; Matsuda, Koichiro; Matsuda, Mitsuru; Ogino, Hidero; Fujinaga, Hiroshi; Terada, Itsuro; Shimizu, Koïchi; Uchiyama, Akio; Ishizawa, Shin; Abo, Hitoshi; Doi, Hiroshi; Noda, Yoichi

doi:10.1111/j.1365-2036.2012.05221.x

Cited by 77 publications

(59 citation statements)

References 46 publications

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“…Although herbal drug use is unconfirmed in many MP cases, cases with long-term intake of herbal medicine have increased (5)(6)(7)(8).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, several cases of MP related to the long-term intake of herbal medicine were reported (5)(6)(7)(8). In particular, the usage of gardenia fruit ('sanshishi' in Japanese), an important crude drug, has been attracting attention.…”

Section: Bosclerosis)mentioning

confidence: 99%

“…In particular, the usage of gardenia fruit ('sanshishi' in Japanese), an important crude drug, has been attracting attention. Hiramatsu et al reported that MP patients in his study took the common ingredient of gardenia fruit over a long period of time (8).…”

Section: Bosclerosis)mentioning

confidence: 99%

“…Undiagnosed cases of MP may present without any clinical checkup, as it can be asymptomatic (8,11). As such, the condition is considered to be a rare disease.…”

Section: Bosclerosis)mentioning

confidence: 99%

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Clinical Search for Undiagnosed Mesenteric Phlebosclerosis at Outpatient Departments Specializing in Herbal (Kampo) Medicine

et al. 2016

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Objective Mesenteric phlebosclerosis (MP) is a disease characterized by calcification of the mesenteric vein, which causes chronic mesenteric ischemia. Recently, the long-term intake of gardenia fruit ('Sanshishi' in Japanese) has been attracting attention as a possible cause. Usually, only advanced, severe MP cases get reported. However, we suspected that some latent cases of this disease may exist.We performed this study in order to determine the prediagnostic cases at our outpatient departments of herbal (Kampo) medicine, with particular attention paid to the initial changes, such as any slight color change of the colon, as shown in colonoscopy. Methods We recommend colonoscopy and computed tomography (CT) scans for patients with a long-term history of taking herbal medicines containing gardenia fruit. Clinical examinations were performed upon receiving patients' consent from December 2013 to November 2014. Results Of the 103 patients who took gardenia fruit long-term, 29 agreed to be checked for MP. 14 patients underwent colonoscopy. Four patients were confirmed to have MP due to the presence of fibrotic deposition of the colonic membrane on histological inspection. Twenty-one patients underwent abdominal CT screening. Characteristic calcification of the mesenteric vein was observed on CT scans in 2 patients. All 4 MP patients took Kampo formulas containing gardenia fruit for more than 6.8 years. The other patients did not develop MP, despite long-term gardenia fruit intake. Conclusion We detected the latent and undiagnosed MP cases. All diagnoses were made while paying careful attention to any slight changes in colonoscopy and CT scans.

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“…Although herbal drug use is unconfirmed in many MP cases, cases with long-term intake of herbal medicine have increased (5)(6)(7)(8).…”

Section: Discussionmentioning

confidence: 99%

Section: Bosclerosis)mentioning

confidence: 99%

Section: Bosclerosis)mentioning

confidence: 99%

“…Undiagnosed cases of MP may present without any clinical checkup, as it can be asymptomatic (8,11). As such, the condition is considered to be a rare disease.…”

Section: Bosclerosis)mentioning

confidence: 99%

See 2 more Smart Citations

Clinical Search for Undiagnosed Mesenteric Phlebosclerosis at Outpatient Departments Specializing in Herbal (Kampo) Medicine

et al. 2016

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“…In 2012, Hiramatsu et al (5) reported IMP patients often have a history of the long-term use of a Chinese herbal medicine. These Chinese herbal medicines usually included Sansisi (G. jasminoides).…”

mentioning

confidence: 99%

Idiopathic mesenteric phlebosclerosis associated with long-term use of Chinese herbal medicine

Yeh¹,

Lin²,

Kao³

et al. 2018

Turk J Gastroenterol

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Clinical significance of abdominal computed tomography and colonoscopy in the evaluation of phlebosclerotic colitis

Wang,

Weng,

Liou

et al. 2023

The Kaohsiung J of Med Scie

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Clinical manifestations of phlebosclerotic colitis (PC) exhibit significant variability, necessitating diverse treatment strategies depending on disease severity. However, there is limited research exploring the relationship between imaging findings and disease severity. Hence, this retrospective study aimed to analyze the correlation between computed tomography (CT) findings, colonoscopic features, and disease severity. This study compared the abdominal CT characteristics, colonoscopy findings, and treatment modalities of 45 PC patients. CT images were assessed for the severity of mesenteric venous calcification, maximum colonic wall thickness, number of involved colonic segments, and presence of pericolic inflammation. Colonoscopic images were assessed for dark purple discoloration mucosa, erosive and ulcerative lesions, mucosal edema, luminal narrowing, and the number of involved colonic segments. In addition, patients were categorized into three groups: the observation (n = 15), medical treatment (n = 19), and operation (n = 11) groups. In CT images, a significant difference in pericolic inflammation (p = 0.039) was observed among groups. Further, significant differences in dark purple discoloration mucosa (p = 0.033), erosive or ulcerative lesions (p < 0.001), mucosal edema (p < 0.001), luminal narrowing (p = 0.012), and the number of involved colonic segments (p = 0.001) were observed in colonoscopy. Moreover, we found positive correlations between CT and colonoscopy features. In conclusion, CT manifestations and colonoscopy findings exhibited correlation with disease severity in PC. When limited to one diagnostic tool, observations from that tool can infer potential manifestations of the alternative tool.

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Mesenteric phlebosclerosis associated with long‐term oral intake of geniposide, an ingredient of herbal medicine

Abstract: The long-term use of geniposide in herbal medicines appears to be associated with mesenteric phlebosclerosis.

Cited by 77 publications

References 46 publications

Clinical Search for Undiagnosed Mesenteric Phlebosclerosis at Outpatient Departments Specializing in Herbal (Kampo) Medicine

Clinical Search for Undiagnosed Mesenteric Phlebosclerosis at Outpatient Departments Specializing in Herbal (Kampo) Medicine

Idiopathic mesenteric phlebosclerosis associated with long-term use of Chinese herbal medicine

Clinical significance of abdominal computed tomography and colonoscopy in the evaluation of phlebosclerotic colitis

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