Mesenteric Lymphadenitis and Terminal Ileitis is Associated With Yersinia Infection: A Meta-analysis

Fonnes, Siv; Rasmussen, Tilde; Brunchmann, Amanda; Holzknecht, Barbara Juliane; Rosenberg, Jacob

doi:10.1016/j.jss.2021.08.027

Cited by 8 publications

(8 citation statements)

References 30 publications

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“…Second, it included testing for infectious pathogens applying different methods, both by PCR on rectal swabs, serology and histopathology. The serology results make the study results comparable to previous studies and the study is the largest to date [14], though, this analysis method cannot be applied in an acute setting. Third, we reported the results of this trial according to the STROBE and STROCSS 2021 guidelines to increase the transparency of the reporting.…”

Section: Discussionsupporting

confidence: 71%

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Diarrhoea‐causing microorganisms are rare in adult patients undergoing diagnostic laparoscopy for suspected appendicitis: a prospective observational cohort study

Fonnes

Rasmussen

Holzknecht

et al. 2023

APMIS

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We investigated if diarrhoea‐causing bacteria, including Yersinia species, could mimic the symptoms of appendicitis and lead to surgery. This prospective observational cohort study (NCT03349814) included adult patients undergoing surgery for suspected appendicitis. Rectal swabs were analysed with polymerase chain reaction (PCR) for Yersinia, Campylobacter, Salmonella, Shigella and Aeromonas spp. Blood samples were analysed routinely and with an in‐house ELISA serological test for Yersinia enterocolitica antibodies. We compared patients without appendicitis and patients with appendicitis confirmed by histopathology. The outcomes included PCR‐confirmed infection with Yersinia spp., serologic‐confirmed infection with Y. enterocolitica, PCR‐confirmed infection with other diarrhoea‐causing bacteria and Enterobius vermicularis confirmed by histopathology. A total of 224 patients were included, 51 without and 173 with appendicitis, and followed for 10 days. PCR‐confirmed infection with Yersinia spp. was found in one patient (2%) without appendicitis and no patients (0%) with appendicitis (p = 0.23). Serology was positive for Y. enterocolitica for the same patient without appendicitis and two patients with appendicitis (p = 0.54). Campylobacter spp. were detected in 4% vs 1% (p = 0.13) of patients without and with appendicitis, respectively. Infection with Yersinia spp. and other diarrhoea‐causing microorganisms in adult patients undergoing surgery for suspected appendicitis was rare.

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Section: Discussionsupporting

confidence: 71%

“…The estimates below were based on initial serological estimates from a systematic review [14] and used for study size calculation. We estimated that the rate of the Yersinia spp.…”

Section: Methodsmentioning

confidence: 99%

Diarrhoea‐causing microorganisms are rare in adult patients undergoing diagnostic laparoscopy for suspected appendicitis: a prospective observational cohort study

Fonnes

Rasmussen

Holzknecht

et al. 2023

APMIS

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“…The Enterobacteriaceae family includes the food-borne pathogen Yersinia enterocolitica, responsible for yersiniosis in humans, a gastrointestinal disease that could simulate appendicitis and can cause mesenteric lymphadenitis, reactive arthritis, erythema nodosum, and conjunctivitis [ 208 , 209 ]. The disease appears to be widespread, with ca.…”

Section: Resultsmentioning

confidence: 99%

Presence of Foodborne Bacteria in Wild Boar and Wild Boar Meat—A Literature Survey for the Period 2012–2022

Altissimi

Noé-Nordberg²,

Ranucci

et al. 2023

Foods

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The wild boar is an abundant game species with high reproduction rates. The management of the wild boar population by hunting contributes to the meat supply and can help to avoid a spillover of transmissible animal diseases to domestic pigs, thus compromising food security. By the same token, wild boar can carry foodborne zoonotic pathogens, impacting food safety. We reviewed literature from 2012–2022 on biological hazards, which are considered in European Union legislation and in international standards on animal health. We identified 15 viral, 10 bacterial, and 5 parasitic agents and selected those nine bacteria that are zoonotic and can be transmitted to humans via food. The prevalence of Campylobacter, Listeria monocytogenes, Salmonella, Shiga toxin-producing E. coli, and Yersinia enterocolitica on muscle surfaces or in muscle tissues of wild boar varied from 0 to ca. 70%. One experimental study reported the transmission and survival of Mycobacterium on wild boar meat. Brucella, Coxiella burnetii, Listeria monocytogenes, and Mycobacteria have been isolated from the liver and spleen. For Brucella, studies stressed the occupational exposure risk, but no indication of meat-borne transmission was evident. Furthermore, the transmission of C. burnetii is most likely via vectors (i.e., ticks). In the absence of more detailed data for the European Union, it is advisable to focus on the efficacy of current game meat inspection and food safety management systems.

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“…In one study from Ireland, it was estimated (based on serologic testing) that up to 4% of patients undergoing appendectomies had acute YE infections [ 9 ]. At the time of surgery, such patients tend to have enlarged mesenteric lymph nodes (mesenteric adenitis) with a normal or slightly inflamed appendix [ 9 ]. YE may be cultured from involved lymph nodes and the distal ileum [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…At the time of surgery, such patients tend to have enlarged mesenteric lymph nodes (mesenteric adenitis) with a normal or slightly inflamed appendix [ 9 ]. YE may be cultured from involved lymph nodes and the distal ileum [ 9 ]. The risk of invasive disease increases in persons with chronic illnesses or immunosuppressive diseases, conditions that predispose to iron overload like thalassemia and hemochromatosis, therapy with deferoxamine, and transfusion-associated infections; these patients can present with septic shock in the setting of YE infections.…”

Section: Discussionmentioning

confidence: 99%

Yersinia Enterocolitica Sepsis in an Elderly Male With No Iron Overload: A Case Report From the Northeastern United States

Alnabwani

Durrani

Prasad

et al. 2022

Cureus

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Mesenteric Lymphadenitis and Terminal Ileitis is Associated With Yersinia Infection: A Meta-analysis

Cited by 8 publications

References 30 publications

Diarrhoea‐causing microorganisms are rare in adult patients undergoing diagnostic laparoscopy for suspected appendicitis: a prospective observational cohort study

Diarrhoea‐causing microorganisms are rare in adult patients undergoing diagnostic laparoscopy for suspected appendicitis: a prospective observational cohort study

Presence of Foodborne Bacteria in Wild Boar and Wild Boar Meat—A Literature Survey for the Period 2012–2022

Yersinia Enterocolitica Sepsis in an Elderly Male With No Iron Overload: A Case Report From the Northeastern United States

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