Mesenteric fat in Crohn's disease: a pathogenetic hallmark or an innocent bystander?

Peyrin–Biroulet, Laurent; Chamaillard, Mathias; Gonzalez, Florent; Béclin, Elodie; Decourcelle, Cécilia; Antunes, Laurent; Neut, Christel; Colombel, Jean–Frédéric; Desreumaux, Pierre

doi:10.1136/gut.2005.082925

Cited by 203 publications

(174 citation statements)

References 66 publications

(65 reference statements)

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“…For example, in Crohn disease, ''thickened and stiff'' mesenteric adipose tissue associated with increased local inflammatory mediators and fibrosis often develops. 3 Fibrosis as a desmoplastic response is seen in the setting of other malignancies. One of the hallmarks of small bowel carcinoid tumors, for example, is the occurrence of fibrosis both locally and distant from the primary tumor, including in the retroperitoneum.…”

Section: Discussionmentioning

confidence: 99%

Association of Clinical and Radiographic Features with Perinephric “Sticky” Fat

Bylund

Han

Crispen

et al. 2013

Journal of Endourology

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Background and Purpose: The discovery of thick, adherent, perinephric sticky fat (PSF) is relatively common during open or laparoscopic retroperitoneal surgery. To our knowledge, however, there has been no previous analysis of clinical or radiographic features associated with the development of PSF or of perioperative outcomes for those patients in whom it is found. Our objective is to analyze potential predictive features and determine whether there is any effect on clinical or pathologic outcomes for patients with perinephric sticky fat. Patients and Methods: Patients undergoing partial nephrectomy or laparoscopic cryoablation with available preoperative imaging were identified from 2005 to 2011. Operative records were reviewed to identify patients with and without PSF. Preoperative images and medical records were examined to obtain patient data regarding potential predictors as well as clinical and pathologic outcomes. Results: A total of 29 patients were identified-16 with PSF and 13 controls. Statistically significant factors associated with PSF included sex, tumor size, presence of perinephric stranding, tumor > 50% exophytic, and thickness of perinephric fat (P < 0.05). Median total operative time for patients with sticky fat was nearly 40 minutes longer than the control group (228 min vs 190 min, P < 0.05). All four (17%) patients with Fuhrman grade 3 or 4 renal-cell carcinoma were from the sticky fat group (P = 0.09). Conclusions: Despite the small sample size, multiple possible factors associated with perinephric sticky fat were identified and may provide guidance for future investigation of this phenomenon.

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Section: Discussionmentioning

confidence: 99%

Association of Clinical and Radiographic Features with Perinephric “Sticky” Fat

Bylund

Han

Crispen

et al. 2013

Journal of Endourology

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“…O tecido adiposo é importante fonte de citocinas e produz cerca de 30% da interleucina-6 (IL-6) circulante. Avaliações cirúrgicas do intestino na DC revelaram que o mesentério é com frequência espessado e endurecido, com supercrescimento de gordura 25 . O acúmulo de gordura intra-abdominal observado nestes pacientes possivelmente está relacionado ao desenvolvimento e progressão da doença 16 .…”

Section: Introductionunclassified

Relação entre estado nutricional e atividade inflamatória em pacientes com doença inflamatória intestinal

Silva

Schieferdecker

Rocco

et al. 2010

ABCD, arq. bras. cir. dig.

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DESCRITORES -Doença InflamatóriaIntestinal. Avaliação nutricional. Obesidade. ABSTRACT -Background -The inflammatory bowel diseases are characterized by multiple digestive tract symptoms and therefore may interfere with nutritional status. Aim -To assess the nutritional status of patients with inflammatory bowel disease in different stages of inflammatory activity. Methods -Fifty five patients with inflammatory bowel disease were demographically evaluated with weight measurement, height, arm circumference and triceps skinfold and had their body composition determined by bioelectrical impedance. For determination of inflammatory activity of the disease were used serum C-reactive protein and the index of Harvey and Bradshaw. To compare means it was used the unpaired t test, and the average non-parametric, the Mann-Whitney test, level of significance p <0.05. Results -Among the patients, 28 had Crohn's disease and 27 ulcerative colitis, aged between 19 and 63 years and time since diagnosis 1-22 years. There was no difference in anthropometric measurements and body composition of patients whose disease was inflammatory activity or in remission. Patients who used glucocorticoids in the six months preceding the assessment showed body fat percentage of 23.4 ± 8.2% whilst those who did not use the percentage was 30.7 ± 11.3 (p <0.0199). The most common gastrointestinal symptoms were abdominal distension (41%), diarrhea (18%), nausea (13%), constipation (12%), anorexia (11%) and vomiting (5%). All symptoms were more common in patients with higher body mass index and body fat. Conclusion -There were more patients with excess weight and body fat, and these patients were more symptomatic and had higher values of C-reactive protein. RESUMO -Racional

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“…Therefore, intra-abdominal MAT, which is anatomically comparable in mice and humans, may present a more suitable depot for comparative analysis of adipose tissue impairments in obesity. Compared with other fat depots, MAT shows apparently functional differences in gene expression and higher metabolic activity, and it has been implicated in the development of metabolic syndrome and inflammatory bowel diseases (5,51,60,74). For example, creeping fat in patients with Crohn's disease refers to hypertrophy of MAT located around the inflamed intestine, and only a few studies have addressed the contribution of MAT in the development of insulin resistance (7,16).…”

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confidence: 99%