Mesenchymoma of the lung (so called hamartoma): a review of 154 parenchymal and endobronchial cases.

Bosch, J.L.H. Ruud; Wagenaar, Sjoerd Sc.; Corrin, B.; Elbers, J. R. J.; Knaepen, Paul J.; Westermann, C. J. J.

doi:10.1136/thx.42.10.790

Cited by 135 publications

(100 citation statements)

References 10 publications

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“…The explanation for the presence of pleural droplets is not clearly proved. Multicentric growth may explain the pleural droplets, but this is unlikely because multiple growths are decidedly rare (2).…”

Section: Discussionmentioning

confidence: 99%

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Radiological Findings of Giant Pulmonary Chondromatous Hamartoma: Case Report

Park

Kim

et al. 2005

J Korean Radiol Soc

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Hamartomas, which are classified as either chondromatous or leiomyomatous, are the most common benign tumors of the lung. However, multiple pulmonary chondromatous hamartomas are rare with less than 20 cases having been previously reported (1). These lesions have also been known to coexist with certain other diseases. The majority of such tumors are small and solitary (2). We present a case of a giant pulmonary chondromatous hamartoma with multiple satellite nodules in the adjacent lung and parietal pleura, which was followed for three years since it was originally discovered. Case ReportA 40-year-old woman presented with progressive dyspnea for one month. Three years before a pleural-based mass in the patient's left lung was discovered incidentally, but the patient ignored the recommendation for further evaluation of the lesion (Fig. 1A). Follow-up chest radiographs showed interval growth of the mass that occupied the left hemi-thorax from the diaphragm to the aortic arch and a newly developed pleural effusion (Fig. 1B).Contrast-enhanced CT (5-mm collimation) revealed a huge mass with peripherally thick linear calcifications, soft tissue densities, and ill-defined fat densities (HU: 40 50) (Fig. IC). A small amount of pleural effusion and an adjacent atelectasis of the left lower lobe were combined. MR imaging was performed to evaluate the resectability of the mass. A pre-enhanced axial T1-weighted image (TR/TE 158/6.2) showed well-defined heterogenous intermediate signal intensity (higher than that of skeletal muscle but lower than that of fat) of the mass without typical signal intensity representing the fat and the calcification (Fig. 1D). However, the calcification showed various signal intensities on MR images and a partial averaging effect could not be excluded. A contrast-en- Among lung tumors, multiple hamartomas are uncommon and multiple chondromatous hamartomas are extremely rare. In this report, we describe a patient with an interval growth of a giant chondromatous hamartoma with accompanying multiple satellite nodules in the adjacent lung and the parietal pleura. We also present the follow up chest radiograph, computed tomograph, magnetic resonance images and photographs of the operating field of the tumor with pathologic correlation.

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Section: Discussionmentioning

confidence: 99%

“…The majority are smaller than 4 cm and solitary. Most are located within the parenchyma, usually in a peripheral location (2,3). Multiple pulmonary hamartomas are rare with an incidence of 2.8%.…”

Section: Discussionmentioning

confidence: 99%

Radiological Findings of Giant Pulmonary Chondromatous Hamartoma: Case Report

Park

Kim

et al. 2005

J Korean Radiol Soc

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“…This approach has been adopted in 9.5-11% of patients with endobronchial hamartoma. 9) With a highfrequency electrosurgical snare, it is possible to resect a pedunculated tumour located in the central airway proximal to the subsegmental bronchi, while reducing the risk of postoperative complications such as pneumonia. This approach also allows histological investigation of the resected tumour.…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Cartilaginous Hamartoma in a Wheezing Patient: A Case Report

Akahoshi

Endo

Onose

et al. 2014

Nichidai Igaku Zasshi

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A 57-year-old man presented to a local clinic with gradually progressive wheezing and was referred to our hospital. Chest computed tomography revealed atelectasis in the lingular segment of the left lung and a polypoid lesion in the left main bronchus. Endoscopic resection of the endobronchial tumour was performed with a high-frequency electrosurgical snare under general anaesthesia. Based on histological examination of the resected specimen, an endobronchial cartilaginous hamartoma was diagnosed. This approach may be an alternative for resection of selected benign endobronchial tumours. After 2 years of follow up, the patient remains free of disease. While endobronchial hamartoma is relatively rare, this diagnosis should be considered in a patient with respiratory complaints, such as gradual progression of wheezing and persistent cough.

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“…They account for approximately three-quarters of all benign lung neoplasms and have an overall incidence between 0.25% and 5.7% [1] . The term pulmonary 'hamartoma' is nosologically incorrect since this lesion is probably a benign neoplasm, derived from bronchial wall mesenchyme [2] . Over 90% of hamartomas have a peripheral location and are asymptomatic, typically presenting in the seventh decade as a solitary nodule or mass with a well-defined smooth or slightly lobulated margin [1] .…”

Section: Fat-containing Neoplasmsmentioning

confidence: 99%

“…These are very slow-growing tumours with a mean size of 4 cm, although rapid growth and tumours of 10 cm diameter have been documented [3,4] . Hamartomas have an endobronchial location in 1.5-8% of cases, appearing as a pedunculated polyploid mass attached to the bronchial mucosa, and only rarely are they continuous with the bronchial cartilage [2,5,6] . Although hamartomas contain fibrous tissue, adipose and cartilage, the proportions of these constituents is variable.…”

Section: Fat-containing Neoplasmsmentioning

confidence: 99%